Browsing by Author "Shoelson, Steven"
Now showing items 1-5 of 5
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Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function
Oh, Juhyun; Sinha, Indranil; Tan, Kah Yong; Rosner, Bernard; Dreyfuss, Jonathan M.; Gjata, Ornela; Tran, Peter; Shoelson, Steven E.; Wagers, Amy J. (Impact Journals LLC, 2016)Skeletal muscle is a highly regenerative tissue, but muscle repair potential is increasingly compromised with advancing age. In this study, we demonstrate that increased NF-κB activity in aged muscle fibers contributes to ... -
The Impact of Salsalate Treatment on Serum Levels of Advanced Glycation End Products in Type 2 Diabetes
Barzilay, Joshua I.; Jablonski, Kathleen A.; Fonseca, Vivian; Shoelson, Steven E.; Goldfine, Allison B.; Strauch, Christopher; Monnier, Vincent M. (American Diabetes Association, 2014)OBJECTIVE Salsalate is a nonacetylated salicylate that lowers glucose levels in people with type 2 diabetes (T2D). Here we examined whether salsalate also lowered serum-protein-bound levels of early and advanced glycation ... -
PPARγ is a Major Driver of the Accumulation and Phenotype of Adipose-Tissue \(T_{reg}\) Cells
Cipolletta, Daniela; Feuerer, Markus; Li, Amy; Kamei, Nozomu; Lee, Jongsoon; Shoelson, Steven E.; Benoist, Christophe O.; Mathis, Diane J. (Nature Publishing Group, 2012)Obesity and type-2 diabetes have increased markedly over the past few decades, in parallel. One of the major links between these two disorders is chronic, low-grade inflammation. Prolonged nutrient excess promotes the ... -
Regulation of Diet-Induced Adipose Tissue and Systemic Inflammation by Salicylates and Pioglitazone
Kim, Myung-Sunny; Yamamoto, Yasuhiko; Kim, Kyungjin; Kamei, Nozomu; Shimada, Takeshi; Liu, Libin; Moore, Kristin; Woo, Ju Rang; Shoelson, Steven E.; Lee, Jongsoon (Public Library of Science, 2013)It is increasingly accepted that chronic inflammation participates in obesity-induced insulin resistance and type 2 diabetes (T2D). Salicylates and thiazolidinediones (TZDs) both have anti-inflammatory and anti-hyperglycemic ... -
Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes
King, Aileen J. F.; Guo, Yongjing; Cai, Dongsheng; Hollister-Lock, Jennifer; Morris, Brooke; Salvatori, Alison; Corbett, John A.; Bonner-Weir, Susan; Weir, Gordon C.; Shoelson, Steven E. (Public Library of Science, 2013)The activation of the transcription factor NF-κB leads to changes in expression of many genes in pancreatic β-cells. However, the role of NF-κB activation in islet transplantation has not been fully elucidated. The aim of ...