Browsing by Author "Yao, Qiuming"

Now showing items 1-2 of 2

    • Augmenting and Directing Robust, Long-Range CRISPR-Mediated Activation in Human Cells 

      Tak, Y. Esther; Horng, Joy E.; Perry, Nicholas T.; Schultz, Hayley; Iyer, Sowmya; Yao, Qiuming; Zou, Luli S.; Aryee, Martin; Pinello, Luca; Joung, Keith (Springer Science and Business Media LLC, 2021-08-05)
      Epigenetic editing is an emerging technology that uses artificial transcription factors (aTFs) to regulate expression of a target gene. Although human genes can be robustly upregulated by targeting aTFs to promoters, the ...

    • Therapeutic Base Editing of Human Hematopoietic Stem Cells 

      Zeng, Jing; Wu, Yuxuan; Ren, Chunyan; Bonanno, Jasmine; Shen, Anne H.; Shea, Devlin; Gehrke, Jason M.; Clement, Kendell; Luk, Kevin; Yao, Qiuming; Kim, Rachel; Wolfe, Scot A.; Manis, John; Pinello, Luca; Joung, Keith; Bauer, Daniel (Springer Science and Business Media LLC, 2020-03-16)
      Base editing by nucleotide deaminases linked to programmable DNA-binding proteins represents a promising approach to permanently remedy blood disorders, although its application in engrafting hematopoietic stem cells (HSCs) ...