Now showing items 1-3 of 3

    • Amino acid–insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells 

      Kalaitzidis, Demetrios; Lee, Dongjun; Efeyan, Alejo; Kfoury, Youmna Sami; Nayyar, Naema; Sykes, David Brian; Mercier, Francois; Papazian, Ani Elizabeth; Baryawno, Ninib; Victora, Gabriel D.; Neuberg, Donna S.; Sabatini, David Alexander; Scadden, David Thomas (American Society for Clinical Investigation, 2017)
      The mTOR pathway is a critical determinant of cell persistence and growth wherein mTOR complex 1 (mTORC1) mediates a balance between growth factor stimuli and nutrient availability. Amino acids or glucose facilitates mTORC1 ...
    • Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin 

      Palchaudhuri, Rahul; Saez, Borja; Hoggatt, Jonathan George; Schajnovitz, Amir; Sykes, David Brian; Tate, Tiffany A; Czechowicz, Agnieszka; Kfoury, Youmna Sami; Ruchika, FNU; Rossi, Derrick J; Verdine, Gregory L.; Mansour, Michael Karim; Scadden, David Thomas (Springer Nature, 2016)
      Hematopoietic stem cell transplantation (HSCT) offers curative therapy for patients with hemoglobinopathies, congenital immunodeficiencies, and other conditions, possibly including AIDS. Autologous HSCT using genetically ...
    • Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors 

      Lee, Dongjun; Sykes, Stephen M.; Kalaitzidis, Demetrios; Lane, Andrew A.; Kfoury, Youmna; Raaijmakers, Marc H.G.P.; Wang, Ying-Hua; Armstrong, Scott A.; Scadden, David T. (Elsevier, 2014)
      Summary Central to cellular proliferative, survival, and metabolic responses is the serine/threonine kinase mTOR, which is activated in many human cancers. mTOR is present in distinct complexes that are either modulated ...