Browsing by Author "Schneeweiss, Sebastian"
Now showing items 1-20 of 20
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Active safety monitoring of newly marketed medications in a distributed data network: application of a semi-automated monitoring system
Gagne, Joshua J.; Glynn, Robert J.; Rassen, Jeremy A.; Walker, Alexander M.; Daniel, Gregory W.; Sridhar, Gayathri; Schneeweiss, Sebastian (2014)We developed a semi-automated active monitoring system that uses sequential matched-cohort analyses to assess drug safety across a distributed network of longitudinal electronic healthcare data. In a retrospective analysis, ... -
Comparative safety of anesthetic type for hip fracture surgery in adults: retrospective cohort study
Patorno, Elisabetta; Neuman, Mark D; Schneeweiss, Sebastian; Mogun, Helen; Bateman, Brian T (BMJ Publishing Group Ltd., 2014)Objective: To evaluate the effect of anesthesia type on the risk of in-hospital mortality among adults undergoing hip fracture surgery in the United States. Design: Retrospective cohort study. Setting: Premier research ... -
Confounding Adjustment in Comparative Studies of Newly Marketed Medications
Kumamaru, Hiraku (2015-01-20)Observational studies of newly marketed medications can add important safety and effectiveness information to what is known from pre-approval randomized controlled trials. As new medications are often prescribed to select ... -
Development of a Health Care Utilisation Data-Based Index for Rheumatoid Arthritis Severity: A Preliminary Study
Ting, Gladys; Schneeweiss, Sebastian; Scranton, Richard E.; Katz, Jeffrey; Weinblatt, Michael; Young, Melissa; Avorn, Jerome; Solomon, Daniel (Springer Science and Business Media LLC, 2008-08-21)Introduction Health care utilisation ('claims') databases contain information about millions of patients and are an important source of information for a variety of study types. However, they typically do not contain ... -
Differential Risk of Death in Older Residents in Nursing Homes Prescribed Specific Antipsychotic Drugs: Population Based Cohort Study
Huybrechts, Krista F.g.; Gerhard, T; Crystal, S; Olfson, M; Avorn, Jerry Lewis; Levin, Robert Marc; Lucas, J. A.; Schneeweiss, Sebastian (BMJ Publishing Group Ltd., 2012)Objective: To assess risks of mortality associated with use of individual antipsychotic drugs in elderly residents in nursing homes. Design Population based cohort study with linked data from Medicaid, Medicare, the Minimum ... -
Dimension reduction and shrinkage methods for high dimensional disease risk scores in historical data
Kumamaru, Hiraku; Schneeweiss, Sebastian; Glynn, Robert J.; Setoguchi, Soko; Gagne, Joshua J. (BioMed Central, 2016)Background: Multivariable confounder adjustment in comparative studies of newly marketed drugs can be limited by small numbers of exposed patients and even fewer outcomes. Disease risk scores (DRSs) developed in historical ... -
Effects of Xanthine Oxidase Inhibitors on Cardiovascular Disease in Patients with Gout: A Cohort Study
Kim, Seoyoung Catherine; Schneeweiss, Sebastian; Choudhry, Niteesh Kumar; Liu, Jun; Glynn, Robert James; Solomon, Daniel Hal (Elsevier BV, 2015)BACKGROUND: Hyperuricemia and gout are associated with an increased risk of cardiovascular disease (CVD). It is unknown whether treating hyperuricemia with xanthine oxidase inhibitors (XOIs), including allopurinol and ... -
Equity in the Receipt of Oseltamivir in the United States During the H1N1 Pandemic
Franklin, Jessica Myers; Choudhry, Niteesh Kumar; Uscher-Pines, Lori; Brill, Gregory; Matlin, Olga S.; Fischer, Michael Adam; Schneeweiss, Sebastian; Avorn, Jerry Lewis; Brennan, Troyen Anthony; Shrank, William (American Public Health Association, 2014)Objectives. We assessed the relationship between individual characteristics and receipt of oseltamivir (Tamiflu) in the United States during the H1N1 pandemic and other flu seasons. Methods. In a cohort of individuals ... -
Near-Real-Time Monitoring of New Drugs: An Application Comparing Prasugrel Versus Clopidogrel
Gagne, Joshua J; Rassen, Jeremy Alfred; Choudhry, Niteesh K; Bohn, R. L.; Patrick, Amanda; Sridhar, G; Daniel, G W; Liu, Jun; Schneeweiss, Sebastian (Springer Science + Business Media, 2014)BACKGROUND: Methods for near-real-time monitoring of new drugs in electronic healthcare data are needed. OBJECTIVE: In a novel application, we prospectively monitored ischemic, bleeding, and mortality outcomes among patients ... -
Oral Bisphosphonates and Risk of Subtrochanteric or Diaphyseal Femur Fractures in a Population-Based Cohort
Kim, Seoyoung Catherine; Schneeweiss, Sebastian; Katz, Jeffrey Neil; Levin, Raisa; Solomon, Daniel Hal (Wiley, 2011)Bisphosphonates are the primary therapy for postmenopausal and glucocorticoid-induced osteoporosis. Case series suggest a potential link between prolonged use of bisphosphonates and low-energy fracture of subtrochanteric ... -
Outcomes of Reference Pricing for Angiotensin-Converting–Enzyme Inhibitors
Schneeweiss, Sebastian; Walker, Alexander M.; Glynn, Robert James; Maclure, Malcolm; Dormuth, Colin; Soumerai, Stephen Bertram (New England Journal of Medicine (NEJM/MMS), 2002)Background In January 1997, reference pricing for angiotensin-converting–enzyme (ACE) inhibitors for patients 65 years of age or older was introduced in British Columbia, Canada. For medications within a specific class, ... -
Patterns of Initiation of Oral Anticoagulants in Patients with Atrial Fibrillation— Quality and Cost Implications
Desai, Nihar R.; Krumme, Alexis A.; Schneeweiss, Sebastian; Shrank, William; Brill, Gregory; Pezalla, Edmund J.; Spettell, Claire M.; Brennan, Troyen Anthony; Matlin, Olga S.; Avorn, Jerry Lewis; Choudhry, Niteesh Kumar (Elsevier BV, 2014)Background. Dabigatran, rivaroxaban, and apixaban have been approved for use in patients with atrial fibrillation based upon randomized trials demonstrating their comparable or superior efficacy and safety relative to ... -
Quantifying the Role of Adverse Events in the Mortality Difference between First and Second-Generation Antipsychotics in Older Adults: Systematic Review and Meta-Synthesis
Jackson, John W.; Schneeweiss, Sebastian; VanderWeele, Tyler J.; Blacker, Deborah (Public Library of Science, 2014)Background: Observational studies have reported higher mortality among older adults treated with first-generation antipsychotics (FGAs) versus second-generation antipsychotics (SGAs). A few studies examined risk for medical ... -
Risk of Ischemic Cerebrovascular and Coronary Events in Adult Users of Anticonvulsant Medications in Routine Care Settings
Patorno, Elisabetta; Glynn, Robert J.; Hernandez‐Diaz, Sonia; Avorn, Jerry; Wahl, Peter M.; Bohn, Rhonda L.; Mines, Daniel; Liu, Jun; Schneeweiss, Sebastian (Blackwell Publishing Ltd, 2013)Background: Older‐generation anticonvulsants that highly induce cytochrome P450 enzyme system activity produce metabolic abnormalities that may increase cardiovascular risk. The objective of this study was to evaluate the ... -
Rosiglitazone and Myocardial Infarction in Patients Previously Prescribed Metformin
Dormuth, Colin R.; Maclure, Malcolm; Carney, Greg; Schneeweiss, Sebastian; Bassett, Ken; Wright, James M. (Public Library of Science, 2009)Objective: Rosiglitazone was found associated with approximately a 43% increase in risk of acute myocardial infarction (AMI) in a two meta-analyses of clinical trials. Our objective is to estimate the magnitude of the ... -
Selective Serotonin Reuptake Inhibitor Use and Perioperative Bleeding and Mortality in Patients Undergoing Coronary Artery Bypass Grafting: A Cohort Study
Gagne, Joshua J; Polinski, Jennifer Milan; Rassen, Jeremy; Fischer, Michael Adam; Seeger, John; Franklin, Jessica Myers; Liu, Jun; Schneeweiss, Sebastian; Choudhry, Niteesh Kumar (Springer Science + Business Media, 2015)INTRODUCTION: Several small studies have reported inconsistent findings about the safety of selective serotonin reuptake inhibitors (SSRIs) among patients undergoing coronary artery bypass grafting (CABG). We sought to ... -
Type of stress ulcer prophylaxis and risk of nosocomial pneumonia in cardiac surgical patients: cohort study
Bateman, Brian T; Bykov, Katsiaryna; Choudhry, Niteesh K; Schneeweiss, Sebastian; Gagne, Joshua J; Polinski, Jennifer M; Franklin, Jessica M; Doherty, Michael; Fischer, Michael A; Rassen, Jeremy A (BMJ Publishing Group Ltd., 2013)Objective: To examine the relation between the type of stress ulcer prophylaxis administered and the risk of postoperative pneumonia in patients undergoing coronary artery bypass grafting. Design: Retrospective cohort ... -
A Unified Framework for Classification of Methods for Benefit-Risk Assessment
Najafzadeh, Mehdi; Schneeweiss, Sebastian; Choudhry, Niteesh Kumar; Bykov, Katsiaryna; Kahler, Kristijan H.; Martin, Diane P.; Gagne, Joshua J (Elsevier BV, 2015)BACKGROUND: Patients, physicians, and other decision makers make implicit but inevitable trade-offs among risks and benefits of treatments. Many methods have been proposed to promote transparent and rigorous benefit-risk ... -
Validation of Claims-Based Algorithms for Identification of High-Grade Cervical Dysplasia and Cervical Cancer
Kim, Seoyoung; Gillet, Victoria G.; Feldman, Sarah; Lii, Huichuan; Toh, Sengwee Darren; Brown, Jeffrey; Katz, Jeffrey; Solomon, Daniel; Schneeweiss, Sebastian (Wiley, 2013-11)Background High-grade cervical dysplasia or cervical intraepithelial neoplasia (CIN) grade 2 or worse has been widely used as a surrogate endpoint in cervical cancer screening or prevention trials. Methods To identify ... -
The Validity of a Rheumatoid Arthritis Medical Records-Based Index of Severity Compared with the DAS28
Sato, Masayo; Schneeweiss, Sebastian; Scranton, Richard; Katz, Jeffrey; Weinblatt, Michael; Avorn, Jerome; Ting, Gladys; Shadick, Nancy; Solomon, Daniel (Springer Science and Business Media LLC, 2006)The objective of this work was to assess the convergent validity of a previously developed rheumatoid arthritis medical records-based index of severity (RARBIS) by comparing it with the 28-joint Disease Activity Score ...