Now showing items 1-10 of 10

    • Complexity and network dynamics in physiological adaptation: An integrated view 

      Baffy, Gyorgy; Loscalzo, Joseph (Elsevier BV, 2014)
      Living organisms constantly interact with their surroundings and sustain internal stability against perturbations. This dynamic process follows three fundamental strategies (restore, explore, and abandon) articulated in ...
    • Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Prevention 

      Baffy, György (XIA & HE Publishing Ltd, 2013)
      Hepatocellular cancer (HCC) is the fifth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Non-alcoholic fatty liver disease (NAFLD), a spectrum of hepatic disorders associated with ...
    • The Impact of Network Medicine in Gastroenterology and Hepatology 

      Baffy, Gyorgy (Elsevier BV, 2013)
      In the footsteps of groundbreaking achievements made by biomedical research, another scientific revolution is unfolding. Systems biology draws from the chaos and complexity theory and applies computational models to predict ...
    • Metformin and Hepatocellular Carcinoma 

      Kilaru, Saikiran Mayi; Baffy, Gyorgy (2015)
      There is ample evidence that type 2 diabetes is an independent risk factor for the development of various cancers including hepatocellular carcinoma (HCC). Metformin, a widely used antidiabetic agent, has been shown to ...
    • MicroRNAs in Nonalcoholic Fatty Liver Disease 

      Baffy, Gyorgy (2015)
      Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disorder. Strongly linked to obesity and diabetes, NAFLD has the characteristics of complex diseases with substantial heterogeneity. Accordingly, ...
    • Mitochondrial recoupling: a novel therapeutic strategy for cancer? 

      Baffy, Gyorgy; Derdak, Z; Robson, Simon Christopher (Nature Publishing Group, 2011)
      Recent findings link metabolic transformation of cancer cells to aberrant functions of mitochondrial uncoupling proteins (UCPs). By inducing proton leak, UCPs interfere with mitochondrial synthesis of adenosine 5′-triphosphate, ...
    • Mitochondrial uncoupling in cancer cells: Liabilities and opportunities 

      Baffy, Gyorgy (Elsevier BV, 2017)
      Acquisition of the endosymbiotic ancestor of mitochondria was a critical event in eukaryote evolution. Mitochon- dria offered an unparalleled source of metabolic energy through oxidative phosphorylation and allowed the de- ...
    • Novel strategies in the pharmacotherapy of nonalcoholic fatty liver disease 

      Baffy, Gyorgy (Promenade Publishing House, 2016)
      Nonalcoholic fatty liver disease (NAFLD) affects an estimated one billion people in the world. NAFLD is a spectrum of disease ranging from steatosis to steatohepatitis with variable outcomes that include cirrhosis and ...
    • Origins of Portal Hypertension in Nonalcoholic Fatty Liver Disease 

      Baffy, Gyorgy (Springer Nature, 2018)
      Nonalcoholic fatty liver disease (NAFLD) advanced to cirrhosis is often complicated by clinically significant portal hypertension, which is primarily caused by increased intrahepatic vascular resistance. Liver fibrosis ...
    • Uncoupling protein-2 and non-alcoholic fatty liver disease 

      Baffy, Gyorgy (Frontiers in Bioscience, 2005)
      Non-alcoholic fatty liver disease (NAFLD) has become the most common form of hepatic disorders in the developed world. NAFLD is part of the metabolic syndrome with insulin resistance as a primary underlying derangement. ...