Now showing items 1-20 of 25

    • Analysis of Salmonella enterica Serotype Paratyphi A Gene Expression in the Blood of Bacteremic Patients in Bangladesh 

      Sheikh, Alaullah; Bhuiyan, Md. Saruar; Khanam, Farhana; Bukka, Archana; Kalsy, Anuj; Porwollik, Steffen; Cravioto, Alejandro; Logvinenko, Tanya; McClelland, Michael; Graham, James E.; Qadri, Firdausi; Charles, Richelle Candice; Rollins, Sean McKenzie; Harris, Jason B.; Brooks, W. Abdullah; Larocque, Regina Celes; Hohmann, Elizabeth Louise; Calderwood, Stephen Beaven; Ryan, Edward Thomas (Public Library of Science, 2010)
      Background: Salmonella enterica serotype Paratyphi A is a human-restricted cause of paratyphoid fever, accounting for up to a fifth of all cases of enteric fever in Asia. Methodology/Principal Findings: In this work, we ...
    • Cellular and Cytokine Responses to Salmonella enterica Serotype Typhi Proteins in Patients with Typhoid Fever in Bangladesh 

      Bhuiyan, Saruar; Sayeed, Abu; Khanam, Farhana; Leung, Daniel T.; Rahman Bhuiyan, Taufiqur; Sheikh, Alaullah; Salma, Umme; LaRocque, Regina C.; Harris, Jason B.; Pacek, Marcin; Calderwood, Stephen B.; LaBaer, Joshua; Ryan, Edward T.; Qadri, Firdausi; Charles, Richelle C. (The American Society of Tropical Medicine and Hygiene, 2014)
      We assessed interferon-gamma (IFN-γ) responses via enzyme-linked immunosorbent spot (ELISPOT) to a number of S. Typhi antigens in samples from humans with S. Typhi bacteremia and typhoid fever in Bangladesh. Compared with ...
    • A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice 

      Sayeed, Md. Abu; Bufano, Meagan Kelly; Xu, Peng; Eckhoff, Grace; Charles, Richelle C.; Alam, Mohammad Murshid; Sultana, Tania; Rashu, Md. Rasheduzzaman; Berger, Amanda; Gonzalez-Escobedo, Geoffrey; Mandlik, Anjali; Bhuiyan, Taufiqur Rahman; Leung, Daniel T.; LaRocque, Regina C.; Harris, Jason B.; Calderwood, Stephen B.; Qadri, Firdausi; Vann, W. F.; Kováč, Pavol; Ryan, Edward T. (Public Library of Science, 2015)
      Background: Vibrio cholerae is the cause of cholera, a severe watery diarrhea. Protection against cholera is serogroup specific. Serogroup specificity is defined by the O-specific polysaccharide (OSP) component of ...
    • Comparative Proteomic Analysis of the PhoP Regulon in Salmonella enterica Serovar Typhi Versus Typhimurium 

      Lebrun, Lauren M.; Sheikh, Alaullah; Logvinenko, Tanya; Tarique, Abdullah; Krastins, Bryan; Qadri, Firdausi; Charles, Richelle Candice; Harris, Jason B.; Chase, Michael Richard; Larocque, Regina Celes; Rollins, Sean McKenzie; Hohmann, Elizabeth Louise; Rosenberg, Ian Morley; Sarracino, David A.; Calderwood, Stephen Beaven; Ryan, Edward Thomas (Public Library of Science, 2009)
      Background: S. Typhi, a human-restricted Salmonella enterica serovar, causes a systemic intracellular infection in humans (typhoid fever). In comparison, S. Typhimurium causes gastroenteritis in humans, but causes a systemic ...
    • Economics of Malaria Prevention in US Travelers to West Africa 

      Adachi, Kenji; Coleman, Margaret S.; Khan, Nomana; Jentes, Emily S.; Arguin, Paul; Rao, Sowmya R.; LaRocque, Regina C.; Sotir, Mark J.; Brunette, Gary; Ryan, Edward T.; Meltzer, Martin I. (Oxford University Press, 2013)
      Background. Pretravel health consultations help international travelers manage travel-related illness risks through education, vaccination, and medication. This study evaluated costs and benefits of that portion of the ...
    • Evaluation in Mice of a Conjugate Vaccine for Cholera Made from Vibrio cholerae O1 (Ogawa) O-Specific Polysaccharide 

      Alam, Mohammad Murshid; Bufano, Megan Kelly; Xu, Peng; Kalsy, Anuj; Yu, Y.; Freeman, Y. Wu; Sultana, Tania; Rashu, Md. Rasheduzzaman; Desai, Ishaan; Eckhoff, Grace; Leung, Daniel T.; Charles, Richelle C.; LaRocque, Regina C.; Harris, Jason B.; Clements, John D.; Calderwood, Stephen B.; Qadri, Firdausi; Vann, W. F.; Kováč, Pavol; Ryan, Edward T. (Public Library of Science, 2014)
      Background: Protective immunity against cholera is serogroup specific. Serogroup specificity in Vibrio cholerae is determined by the O-specific polysaccharide (OSP) of lipopolysaccharide (LPS). Generally, polysaccharides ...
    • High Depth, Whole-Genome Sequencing of Cholera Isolates from Haiti and the Dominican Republic 

      Sealfon, Rachel; Gire, Stephen; Ellis, Crystal Nicole; Calderwood, Stephen Beaven; Qadri, Firdausi; Hensley, Lisa; Kellis, Manolis; Ryan, Edward Thomas; Larocque, Regina Celes; Harris, Jason B.; Sabeti, Pardis Christine (BioMed Central, 2012)
      Background: Whole-genome sequencing is an important tool for understanding microbial evolution and identifying the emergence of functionally important variants over the course of epidemics. In October 2010, a severe cholera ...
    • Household Transmission of Vibrio cholerae in Bangladesh 

      Sugimoto, Jonathan D.; Koepke, Amanda A.; Kenah, Eben E.; Halloran, M. Elizabeth; Chowdhury, Fahima; Khan, Ashraful I.; LaRocque, Regina C.; Yang, Yang; Ryan, Edward T.; Qadri, Firdausi; Calderwood, Stephen B.; Harris, Jason B.; Longini, Ira M. (Public Library of Science, 2014)
      Background: Vibrio cholerae infections cluster in households. This study's objective was to quantify the relative contribution of direct, within-household exposure (for example, via contamination of household food, water, ...
    • Identification of Immunogenic Salmonella enterica Serotype Typhi Antigens Expressed in Chronic Biliary Carriers of S. Typhi in Kathmandu, Nepal 

      Charles, Richelle C.; Sultana, Tania; Alam, Mohammad Murshid; Yu, Yanan; Wu-Freeman, Ying; Bufano, Meagan Kelly; Rollins, Sean M.; Tsai, Lillian; Harris, Jason B.; LaRocque, Regina C.; Leung, Daniel T.; Brooks, W. Abdullah; Nga, Tran Vu Thieu; Dongol, Sabina; Basnyat, Buddha; Calderwood, Stephen B.; Farrar, Jeremy; Khanam, Farhana; Gunn, John S.; Qadri, Firdausi; Baker, Stephen; Ryan, Edward T. (Public Library of Science, 2013)
      Background: Salmonella enterica serotype Typhi can colonize and persist in the biliary tract of infected individuals, resulting in a state of asymptomatic chronic carriage. Chronic carriers may act as persistent reservoirs ...
    • Immunocompromised Travelers: Demographic Characteristics, Travel Destinations, and Pretravel Health Care from the U.S. Global TravEpiNet Consortium 

      Schwartz, Brian S.; Rosen, Jessica; Han, Pauline V.; Hynes, Noreen A.; Hagmann, Stefan H.; Rao, Sowmya R.; Jentes, Emily S.; Ryan, Edward T.; LaRocque, Regina C. (The American Society of Tropical Medicine and Hygiene, 2015)
      An increasing number of immunocompromised individuals are pursuing international travel, and a better understanding of their international travel patterns and pretravel health care is needed. We evaluated the clinical ...
    • Immunogenicity of a Killed Bivalent (O1 and O139) Whole Cell Oral Cholera Vaccine, Shanchol, in Haiti 

      Charles, Richelle C.; Hilaire, Isabelle J.; Mayo-Smith, Leslie M.; Teng, Jessica E.; Jerome, J. Gregory; Franke, Molly F.; Saha, Amit; Yu, Yanan; Kováč, Paul; Calderwood, Stephen B.; Ryan, Edward T.; LaRocque, Regina C.; Almazor, Charles P.; Qadri, Firdausi; Ivers, Louise C.; Harris, Jason B. (Public Library of Science, 2014)
      Background: Studies of the immunogenicity of the killed bivalent whole cell oral cholera vaccine, Shanchol, have been performed in historically cholera-endemic areas of Asia. There is a need to assess the immunogenicity ...
    • Immunologic Responses to Vibrio cholerae in Patients Co-Infected with Intestinal Parasites in Bangladesh 

      Bhuiyan, Taufiqur R.; Chowdhury, Fahima; Khan, Ashraful I.; Logvinenko, Tanya; Kendall, Jennifer; Faruque, Abu S. G.; Nagler, Cathryn R.; Qadri, Firdausi; Harris, Jason B.; Podolsky, Michael Jeffrey; Larocque, Regina Celes; Ryan, Edward Thomas; Calderwood, Stephen Beaven (Public Library of Science, 2009)
      Background: Infection with intestinal helminths is common and may contribute to the decreased efficacy of Vibrio cholerae vaccines in endemic compared to non-endemic areas. However, the immunomodulatory effects of concomitant ...
    • Individuals with Le(a+b−) Blood Group have Increased Susceptibility to Symptomatic \(Vibrio\) \(cholerae\) O1 Infection 

      Arifuzzaman, Mohammad; Ahmed, Tanvir; Chowdhury, Fahima; Rashu, Rasheduzzaman; Khan, Ashraful I.; Bhuiyan, Taufiqur Rahman; Qadri, Firdausi; Rahman, Mohammad Arif; Larocque, Regina Celes; Harris, Jason B.; Ryan, Edward Thomas; Calderwood, Stephen Beaven (Public Library of Science, 2011)
      Background: Human genetic factors such as blood group antigens may affect the severity of infectious diseases. Presence of specific ABO and Lewis blood group antigens has been shown previously to be associated with the ...
    • Natural Selection in a Bangladeshi Population from the Cholera-Endemic Ganges River Delta 

      Karlsson, Elinor Kathryn; Harris, J. B.; Tabrizi, Shervin; Rahman, A.; Shlyakhter, Ilya; Patterson, N.; O, C.; Schaffner, Stephen; Gupta, S.; Chowdhury, F.; Sheikh, A.; Shin, O. S.; Ellis, C.; Becker, C. E.; Stuart, L. M.; Calderwood, Stephen Beaven; Ryan, Edward Thomas; Qadri, F.; Sabeti, Pardis Christine; Larocque, Regina Celes (American Association for the Advancement of Science (AAAS), 2013)
      As an ancient disease with high fatality, cholera has likely exerted strong selective pressure on affected human populations. We performed a genome-wide study of natural selection in a population from the Ganges River ...
    • Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh 

      Falkard, Brie; Uddin, Taher; Arifur Rahman, M.; Franke, Molly F.; Aktar, Amena; Uddin, Muhammad Ikhtear; Bhuiyan, Taufiqur Rahman; Leung, Daniel T.; Charles, Richelle C.; Larocque, Regina C.; Harris, Jason B.; Calderwood, Stephen B.; Qadri, Firdausi; Ryan, Edward T. (The American Society of Tropical Medicine and Hygiene, 2015)
      Vibrio cholerae, the cause of cholera, induces both innate and adaptive immune responses in infected humans. Leptin is a hormone that plays a role in both metabolism and mediating immune responses. We characterized leptin ...
    • Pre-Travel Health Care of Immigrants Returning Home to Visit Friends and Relatives 

      Larocque, Regina Celes; Deshpande, Bhushan R.; Rao, Sowmya R.; Brunette, Gary W.; Sotir, Mark J.; Jentes, Emily S.; Ryan, Edward Thomas (The American Society of Tropical Medicine and Hygiene, 2013)
      Immigrants returning home to visit friends and relatives (VFR travelers) are at higher risk of travel-associated illness than other international travelers. We evaluated 3,707 VFR and 17,507 non-VFR travelers seen for ...
    • Pre-Travel Medical Preparation of Business and Occupational Travelers: An Analysis of the Global TravEpiNet Consortium, 2009 to 2012 

      Khan, Nomana M.; Jentes, Emily S.; Brown, Clive; Han, Pauline; Rao, Sowmya R.; Kozarsky, Phyllis; Hagmann, Stefan H.F.; LaRocque, Regina C.; Ryan, Edward T. (Lippincott Williams & Wilkins, 2015)
      Objectives: The aim of the study was to understand more about pre-travel preparations and itineraries of business and occupational travelers. Methods: De-identified data from 18 Global TravEpiNet clinics from January 2009 ...
    • Pre-Travel Preparation of US Travelers Going Abroad to Provide Humanitarian Service, Global TravEpiNet 2009–2011 

      Stoney, Rhett J.; Jentes, Emily S.; Sotir, Mark J.; Kozarsky, Phyllis; Rao, Sowmya R.; LaRocque, Regina C.; Ryan, Edward T. (The American Society of Tropical Medicine and Hygiene, 2014)
      We analyzed characteristics of humanitarian service workers (HSWs) seen pre-travel at Global TravEpiNet (GTEN) practices during 2009–2011. Of 23,264 travelers, 3,663 (16%) travelers were classified as HSWs. Among HSWs, ...
    • Refusal of recommended travel-related vaccines among U.S. international travellers in Global TravEpiNet 

      Lammert, Sara M.; Rao, Sowmya R.; Jentes, Emily S.; Fairley, Jessica K.; Erskine, Stefanie; Walker, Allison T.; Hagmann, Stefan H.; Sotir, Mark J.; Ryan, Edward T.; LaRocque, Regina C. (Oxford University Press, 2016)
      Background: International travellers are at risk of travel-related, vaccine-preventable diseases. More data are needed on the proportion of travellers who refuse vaccines during a pre-travel health consultation and their ...
    • Susceptibility to Vibrio cholerae Infection in a Cohort of Household Contacts of Patients with Cholera in Bangladesh 

      Chowdhury, Fahima; Khan, Ashraful I.; Logvinenko, Tanya; Faruque, Abu S. G.; Qadri, Firdausi; Ko, Albert I.; Harris, Jason B.; Larocque, Regina Celes; Ryan, Edward Thomas; Calderwood, Stephen Beaven (Public Library of Science, 2008)
      Background: Despite recent progress in understanding the molecular basis of Vibrio cholerae pathogenesis, there is relatively little knowledge of the factors that determine the variability in human susceptibility to V. ...