Now showing items 1-6 of 6

    • 20-HETE Mediates Ozone-Induced, Neutrophil-Independent Airway Hyper-Responsiveness in Mice 

      Cooper, Philip R.; Mesaros, A. Clementina; Zhang, Jie; Christmas, Peter; Stark, Christopher M.; Douaidy, Karim; Mittelman, Michael A.; Soberman, Roy Jason; Blair, Ian A.; Panettieri, Reynold A. (Public Library of Science, 2010)
      Background Ozone, a pollutant known to induce airway hyper-responsiveness (AHR), increases morbidity and mortality in patients with obstructive airway diseases and asthma. We postulate oxidized lipids mediate in vivo ...
    • CD200R1 Supports HSV-1 Viral Replication and Licenses Pro-Inflammatory Signaling Functions of TLR2 

      Soberman, Roy Jason; MacKay, Christopher R.; Vaine, Christine Adele; Ryan, Glennice Bowen; Cerny, Anna M.; Thompson, Mikayla R.; Nikolic, Boris; Primo, Valeria; Christmas, Peter; Sheiffele, Paul; Aronov, Lisa; Knipe, David Mahan; Kurt-Jones, Evelyn A. (Public Library of Science, 2012)
      The CD200R1:CD200 axis is traditionally considered to limit tissue inflammation by down-regulating pro-inflammatory signaling in myeloid cells bearing the receptor. We generated CD200R1−/− mice and employed them to explore ...
    • Coordinated regulation of bidirectional COPI transport at the Golgi by cdc42 

      Park, Seung-Yeol; Yang, Jia-Shu; Schmider, Angela B.; Soberman, Roy J.; Hsu, Victor W. (2015)
      The Golgi complex plays a central role in the intracellular sorting of secretory proteins 1,2. Anterograde transport through the Golgi has been explained by the movement of Golgi cisternae, known as cisternal maturation ...
    • Diabetes regulates fructose absorption through thioredoxin-interacting protein 

      Dotimas, James R; Lee, Austin W; Schmider, Angela B; Carroll, Shannon H; Shah, Anu; Bilen, Julide; Elliott, Kayla R; Myers, Ronald B; Soberman, Roy J; Yoshioka, Jun; Lee, Richard T (eLife Sciences Publications, Ltd, 2016)
      Metabolic studies suggest that the absorptive capacity of the small intestine for fructose is limited, though the molecular mechanisms controlling this process remain unknown. Here we demonstrate that thioredoxin-interacting ...
    • Dopa-Responsive Dystonia: Functional Analysis of Single Nucleotide Substitutions within the 5’ Untranslated GCH1 Region 

      Armata, Ioanna A.; Balaj, Leonora; Kuster, John K.; Zhang, Xuan; Tsai, Shelun; Armatas, Andreas A.; Multhaupt-Buell, Trisha J.; Soberman, Roy; Breakefield, Xandra O.; Ichinose, Hiroshi; Sharma, Nutan (Public Library of Science, 2013)
      Background: Mutations in the GCH1 gene are associated with childhood onset, dopa-responsive dystonia (DRD). Correct diagnosis of DRD is crucial, given the potential for complete recovery once treated with L-dopa. The ...
    • An RGS4-Mediated Phenotypic Switch of Bronchial Smooth Muscle Cells Promotes Fixed Airway Obstruction in Asthma 

      Damera, Gautam; Druey, Kirk M.; Cooper, Philip R.; Krymskaya, Vera P.; Soberman, Roy Jason; Amrani, Yassine; Hoshi, Toshinori; Brightling, Christopher E.; Panettieri, Reynold A. (Public Library of Science, 2012)
      In severe asthma, bronchodilator- and steroid-insensitive airflow obstruction develops through unknown mechanisms characterized by increased lung airway smooth muscle (ASM) mass and stiffness. We explored the role of a ...