Browsing by Author "Kufe, Donald"

Now showing items 1-13 of 13

    • Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target 

      Raina, Deepak; Agarwal, Praveen; Lee, James; Bharti, Ajit; McKnight, C. James; Sharma, Pankaj; Kharbanda, Surender; Kufe, Donald (Public Library of Science, 2015)
      Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly expressed in diverse human carcinomas and certain hematologic malignancies. The oncogenic MUC1 transmembrane C-terminal subunit (MUC1-C) functions in part by ...

    • Cockayne Syndrome Protein B Interacts with and Is Phosphorylated by c-Abl Tyrosine Kinase 

      Inman, Syed Z.; Indig, Fred E.; Cheng, Wen-Hsing; Saxena, Satya P.; Stevnsner, Tinna; Kufe, Donald William; Bohr, Vilhelm A. (Oxford University Press, 2007)
      The Cockayne Syndrome group B (CSB) protein plays important roles in transcription, transcription-coupled nucleotide excision repair and base excision DNA repair. c-Abl kinase also plays a role in DNA repair as a ...

    • Cooperative Interaction between the MUC1-C Oncoprotein and the Rab31 GTPase in Estrogen Receptor-Positive Breast Cancer Cells 

      Jin, Caining; Rajabi, Hasan Nabeel; Pitroda, Sean; Li, Ailing; Kharbanda, Akriti; Weichselbaum, Ralph; Kufe, Donald William (Public Library of Science, 2012)
      Rab31 is a member of the Ras superfamily of small GTPases that has been linked to poor outcomes in patients with breast cancer. The MUC1-C oncoprotein is aberrantly overexpressed in most human breast cancers and also confers ...

    • DNA METHYLATION BY DNMT1 AND DNMT3b METHYLTRANSFERASES IS DRIVEN BY THE MUC1-C ONCOPROTEIN IN HUMAN CARCINOMA CELLS 

      Rajabi, Hasan; Tagde, Ashujit; Alam, Maroof; Bouillez, Audrey; Pitroda, Sean; Suzuki, Yozo; Kufe, Donald (2016)
      Aberrant expression of the DNA methyltransferases (DNMTs) and disruption of DNA methylation patterns are associated with carcinogenesis and cancer cell survival. The oncogenic MUC1-C protein is aberrantly overexpressed in ...

    • Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells 

      Hasegawa, Masanori; Takahashi, Hidekazu; Rajabi, Hasan; Alam, Maroof; Suzuki, Yozo; Yin, Li; Tagde, Ashujit; Maeda, Takahiro; Hiraki, Masayuki; Sukhatme, Vikas P.; Kufe, Donald (Impact Journals LLC, 2016)
      The xCT light chain of the cystine/glutamate transporter (system XC−) is of importance for the survival of triple-negative breast cancer (TNBC) cells. The MUC1-C transmembrane oncoprotein is aberrantly overexpressed in ...

    • MUC1 Inhibition Leads to Decrease in PD-L1 Levels via Up-Regulation of miRNAs 

      Pyzer, Athalia Rachel; Stroopinsky, Dina; Rosenblatt, Jacalyn Mara; Anastasiadou, Eleni; Rajabi, Hasan Nabeel; Washington, Abigail; Tagde, Ashujit; Chu, Jen-Hwa; Coll, Maxwell; Jiao, AL; Tsai, LT; Tenen, DE; Cole, Leandra Samantha; Palmer, Kristen; Ephraim, A; Leaf, Rebecca Karp; Nahas, Myrna Rita; Apel, Arie; Bar-Natan, M; Jain, Salvia; McMasters, Malgorzata; Mendez, Lourdes Maria; Arnason, Jon E; Raby, Benjamin Alexander; Slack, Frank; Kufe, Donald William; Avigan, David E. (Springer Nature, 2017)
      The PD-L1/PD-1 pathway is a critical component of the immunosuppressive tumor microenvironment in acute myeloid leukemia (AML), but little is known about its regulation. We investigated the role of the MUC1 oncoprotein in ...

    • MUC1-Associated Proliferation Signature Predicts Outcomes in Lung Adenocarcinoma Patients 

      MacDermed, Dhara M; Khodarev, Nikolai N; Pitroda, Sean P; Edwards, Darrin C; Pelizzari, Charles A; Huang, Lei; Kufe, Donald William; Weichselbaum, Ralph R (BioMed Central, 2010)
      Background: MUC1 protein is highly expressed in lung cancer. The cytoplasmic domain of MUC1 (MUC1-CD) induces tumorigenesis and resistance to DNA-damaging agents. We characterized MUC1-CD-induced transcriptional changes ...

    • MUC1-C ACTIVATES THE TAK1 INFLAMMATORY PATHWAY IN COLON CANCER 

      Takahashi, Hidekazu; Jin, Caining; Rajabi, Hasan; Pitroda, Sean; Alam, Maroof; Ahmad, Rehan; Raina, Deepak; Hasegawa, Masanori; Suzuki, Yozo; Tagde, Ashujit; Bronson, Roderick T.; Weichselbaum, Ralph; Kufe, Donald (2015)
      The mucin 1 (MUC1) oncoprotein has been linked to the inflammatory response by promoting cytokine-mediated activation of the NF-κB pathway. The TGF-β-activated kinase 1 (TAK1) is an essential effector of proinflammatory ...

    • MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells 

      Kharbanda, Akriti; Rajabi, Hasan; Jin, Caining; Alam, Maroof; Wong, Kwok-Kin; Kufe, Donald (Impact Journals LLC, 2014)
      Non-small cell lung cancers (NSCLCs) that harbor an oncogenic KRAS mutation are often associated with resistance to targeted therapies. The MUC1-C transmembrane protein is aberrantly overexpressed in NSCLCs and confers a ...

    • MUC1-C induces DNA methyltransferase 1 and represses tumor suppressor genes in acute myeloid leukemia 

      Tagde, Ashujit; Rajabi, Hasan; Stroopinsky, Dina; Gali, Reddy; Alam, Maroof; Bouillez, Audrey; Kharbanda, Surender; Stone, Richard; Avigan, David; Kufe, Donald (Impact Journals LLC, 2016)
      Aberrant DNA methylation is a hallmark of acute myeloid leukemia (AML); however, the regulation of DNA methyltransferase 1 (DNMT1), which is responsible for maintenance of DNA methylation patterns, has largely remained ...

    • MUC1-C Stabilizes MCL-1 in the Oxidative Stress Response of Triple-Negative Breast Cancer Cells to BCL-2 Inhibitors 

      Hiraki, Masayuki; Suzuki, Yozo; Alam, Maroof; Hinohara, Kunihiko; Hasegawa, Masanori; Jin, Caining; Kharbanda, Surender; Kufe, Donald (Nature Publishing Group, 2016)
      Aberrant expression of myeloid cell leukemia-1 (MCL-1) is a major cause of drug resistance in triple-negative breast cancer (TNBC) cells. Mucin 1 (MUC1) is a heterodimeric oncoprotein that is aberrantly overexpressed in ...

    • TARGETING THE MUC1-C ONCOPROTEIN DOWNREGULATES HER2 ACTIVATION AND ABROGATES TRASTUZUMAB RESISTANCE IN BREAST CANCER CELLS 

      Raina, Deepak; Uchida, Yasumitsu; Kharbanda, Akriti; Rajabi, Hasan; Panchamoorthy, Govind; Jin, Caining; Kharbanda, Surender; Scaltriti, Maurizio; Baselga, Jose; Kufe, Donald (2014)
      Patients with HER2 positive breast cancer often exhibit intrinsic or acquired resistance to trastuzumab treatment. The transmembrane MUC1-C oncoprotein is aberrantly overexpressed in breast cancer cells and associates with ...

    • Targeting the MUC1-C oncoprotein inhibits self-renewal capacity of breast cancer cells 

      Alam, Maroof; Rajabi, Hasan; Ahmad, Rehan; Jin, Caining; Kufe, Donald (Impact Journals LLC, 2014)
      The capacity of breast cancer cells to form mammospheres in non-adherent serum-free culture is used as a functional characteristic of the self-renewing stem-like cell population. The present studies demonstrate that silencing ...