Now showing items 1-6 of 6

    • Cross-national prevalence and risk factors for suicidal ideation, plans and attempts 

      Nock, Matthew K.; Borges, G.; Bromet, E. J.; Alonso, Jose Luis; Angermeyer, M.; Beautrais, A.; Bruffaerts, R.; Chiu, Wai Tat; de Girolamo, G.; Gluzman, S.; de Graaf, R.; Gureje, O.; Haro, J. M.; Huang, Y.; Karam, E.; Kessler, Ronald; Lepine, J. P.; Levinson, D.; Medina-Mora, M. E.; Ono, Y.; Posada-Villa, J.; Williams, David (Royal College of Psychiatrists, 2008)
      Background Suicide is a leading cause of death world-wide; however, the prevalence and risk factors for the immediate precursors to suicide: suicidal ideation, plans and attempts, are not well-known, especially in ...
    • Crystal Structure of the Complete Integrin αVβ3 Ectodomain Plus an α/β Transmembrane Fragment 

      Mahalingham, Bhuvaneshwari; Borrelli, Laura Ann; Rysiok, Thomas; Müller-Pompalla, Dirk; Goodman, Simon L.; Xiong, Jian-Ping; Alonso, Jose Luis; Rui, Xianliang; Anand, Saurabh; Hyman, Bradley Theodore; Arnaout, M. Amin (The Rockefeller University Press, 2009)
      We determined the crystal structure of 1TM-αVβ3, which represents the complete unconstrained ectodomain plus short C-terminal transmembrane stretches of the αV and β3 subunits. 1TM-αVβ3 is more compact and less active in ...
    • Mental disorders among college students in the World Health Organization World Mental Health Surveys 

      Auerbach, Randy Patrick; Alonso, Jose Luis; Axinn, W. G.; Cuijpers, P.; Ebert, D. D.; Green, J. G.; Hwang, Irving; Kessler, Ronald; Liu, Howard; Mortier, Philippe; Nock, Matthew K.; Pinder-Amaker, Stephanie L; Sampson, Nancy A.; Aguilar-Gaxiola, S.; Al-Hamzawi, A.; Andrade, L. H.; Benjet, C.; Caldas-de-Almeida, J. M.; Demyttenaere, K.; Florescu, S.; de Girolamo, G.; Gureje, O.; Haro, J. M.; Karam, E. G.; Kiejna, A.; Kovess-Masfety, V.; Lee, S.; McGrath, J. J.; O, S.; Pennell, B.-E.; Scott, K.; ten Have, M.; Torres, Y.; Zaslavsky, Alan M.; Zarkov, Z.; Bruffaerts, R. (Cambridge University Press (CUP), 2016)
      Background Although mental disorders are significant predictors of educational attainment throughout the entire educational career, most research on mental disorders among students has focused on the primary and secondary ...
    • Parental psychopathology and the risk of suicidal behavior in their offspring: results from the World Mental Health surveys 

      Gureje, O; Oladeji, Bibilola; Hwang, Irving; Chiu, Wai Tat; Kessler, Ronald; Sampson, Nancy A.; Alonso, Jose Luis; Andrade, Luis; Beautrais, A; Borges, G; Bromet, E; Bruffaerts, R; de Girolamo, G; de Graaf, R; Gal, G; He, Y; Hu, C; Iwata, N; Karam, E G; Kovess-Masféty, V; Matschinger, H; Moldovan, M V; Posada-Villa, J; Sagar, R; Scocco, P; Seedat, S; Tomov, Toma; Nock, Matthew K. (Springer Nature, 2010)
      Prior research suggests that parental psychopathology predicts suicidal behavior among offspring; however, the more fine-grained associations between specific parental disorders and distinct stages of the pathway to suicide ...
    • Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys 

      Dehnadi, Abbas; Benedict Cosimi, A.; Neal Smith, Rex; Li, Xiangen; Alonso, José L.; Means, Terry K.; Arnaout, M. Amin (Nature Publishing Group, 2017)
      Ischaemic acute kidney injury (AKI), an inflammatory disease process, often progresses to chronic kidney disease (CKD), with no available effective prophylaxis. This is in part due to lack of clinically relevant CKD models ...
    • Structural basis for pure antagonism of integrin αVβ3 by a high affinity form of fibronectin 

      Van Agthoven, Johannes F.; Xiong, Jian-Ping; Alonso, José Luis; Rui, Xianliang; Adair, Brian D.; Goodman, Simon L.; Arnaout, M. Amin (2014)
      Integrins are important therapeutic targets. However, current RGD-based anti-integrin drugs are also partial agonists, inducing conformational changes that trigger potentially fatal immune reactions and paradoxical cell ...