Browsing by Author "Lemos, Bernardo"
Now showing items 1-10 of 10
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Chromatin-Associated Proteins HP1 and Mod(mdg4) Modify Y-Linked Regulatory Variation in the Drosophila Testis
Branco, Alan; Hartl, Daniel L.; Silva, Bernardo Lemos (Genetics Society of America, 2013)Chromatin remodeling is crucial for gene regulation. Remodeling is often mediated through chemical modifications of the DNA template, DNA-associated proteins, and RNA-mediated processes. Y-linked regulatory variation (YRV) ... -
Epigenetic Effects of Polymorphic Y Chromosomes Modulate Chromatin Components, Immune Response, and Sexual Conflict
Silva, Bernardo Lemos; Hartl, Daniel L.; Branco, Alan T. (National Academy of Sciences, 2010)Genetic conflicts between sexes and generations provide a foundation for understanding the functional evolution of sex chromosomes and sexually dimorphic phenotypes. Y chromosomes of Drosophila contain multi-megabase ... -
The long-range interaction map of ribosomal DNA arrays
Yu, Shoukai; Silva, Bernardo Lemos (Public Library of Science (PLoS), 2018)The repeated rDNA array gives rise to the nucleolus, an organelle that is central to cellular processes as varied as stress response, cell cycle regulation, RNA modification, cell metabolism, genome stability, and production ... -
More epigenetic hits than meets the eye: microRNAs and genes associated with the tumorigenesis of retinoblastoma
Reis, Adriana H. O.; Vargas, Fernando R.; Silva, Bernardo Lemos (Frontiers Media S.A., 2012)Retinoblastoma (RB), a childhood neoplasia of the retinoblasts, can occur unilaterally or bilaterally, with one or multiple foci per eye. RB is associated with somatic loss of function of both alleles of the tumor suppressor ... -
Natural Variation of the Y Chromosome Suppresses Sex Ratio Distortion and Modulates Testis-Specific Gene Expression in Drosophila Simulans
Branco, Alan; Tao, Y; Hartl, Daniel L.; Silva, Bernardo Lemos (Nature Publishing Group, 2013)X-linked sex-ratio distorters that disrupt spermatogenesis can cause a deficiency in functional Y-bearing sperm and a female-biased sex ratio. Y-linked modifiers that restore a normal sex ratio might be abundant and favored ... -
A portrait of ribosomal DNA contacts with Hi-C reveals 5S and 45S rDNA anchoring points in the folded human genome
Yu, Shoukai; Silva, Bernardo Lemos (Oxford University Press (OUP), 2016)Ribosomal rRNAs account for >60% of all RNAs in eukaryotic cells and are encoded in the ribosomal DNA (rDNA) arrays. The rRNAs are produced from two sets of loci: the 5S rDNA array resides exclusively on human chromosome ... -
Ribosomal DNA copy number amplification and loss in human cancers is linked to tumor genetic context, nucleolus activity, and proliferation
Wang, Mengchuan; Silva, Bernardo Lemos (Public Library of Science (PLoS), 2017)Ribosomal RNAs (rRNAs) are transcribed from two multicopy DNA arrays: the 5S ribosomal DNA (rDNA) array residing in a single human autosome and the 45S rDNA array residing in five human autosomes. The arrays are among the ... -
Ribosomal DNA Deletions Modulate Genome-Wide Gene Expression: ‘‘rDNA–Sensitive’’ Genes and Natural Variation
Hartl, Daniel L.; Paredes, Silvana; Branco, Alan; Maggert, Keith A.; Silva, Bernardo Lemos (Public Library of Science, 2011)The ribosomal rDNA gene array is an epigenetically-regulated repeated gene locus. While rDNA copy number varies widely between and within species, the functional consequences of subtle copy number polymorphisms have been ... -
Y Chromosome Mediates Ribosomal DNA Silencing and Modulates the Chromatin State in Drosophila
Zhou, Jun; Sackton, Timothy; Martinsen, Lene; Silva, Bernardo Lemos; Eickbush, Thomas H.; Hartl, Daniel L. (Proceedings of the National Academy of Sciences, 2012)Although the Drosophila Y chromosome is degenerated, heterochromatic, and contains few genes, increasing evidence suggests that it plays an important role in regulating the expression of numerous autosomal and X-linked ... -
Y Not a Dead End: Epistatic Interactions Between Y-Linked Regulatory Polymorphisms and Genetic Background Affect Global Gene Expression in Drosophila melanogaster
Jiang, Pan-Pan Xueke; Hartl, Daniel L.; Silva, Bernardo Lemos (Genetics Society of America, 2010)The Y chromosome, inherited without meiotic recombination from father to son, carries relatively few genes in most species. This is consistent with predictions from evolutionary theory that nonrecombining chromosomes lack ...