Now showing items 1-7 of 7

    • Battery of behavioral tests in mice to study postoperative delirium 

      Peng, Mian; Zhang, Ce; Dong, Yuanlin; Zhang, Yiying; Nakazawa, Harumasa; Kaneki, Masao; Zheng, Hui; Shen, Yuan; Marcantonio, Edward R.; Xie, Zhongcong (Nature Publishing Group, 2016)
      Postoperative delirium is associated with increased morbidity, mortality and cost. However, its neuropathogenesis remains largely unknown, partially owing to lack of animal model(s). We therefore set out to employ a battery ...
    • Primary Role of Functional Ischemia, Quantitative Evidence for the Two-Hit Mechanism, and Phosphodiesterase-5 Inhibitor Therapy in Mouse Muscular Dystrophy 

      Asai, Akihiro; Sahani, Nita Dushyant; Kaneki, Masao; Ouchi, Yasuyoshi; Martyn, J. A Jeevendra; Yasuhara, Shingo (Public Library of Science, 2007)
      Background: Duchenne Muscular Dystrophy (DMD) is characterized by increased muscle damage and an abnormal blood flow after muscle contraction: the state of functional ischemia. Until now, however, the cause-effect relationship ...
    • Recombinant human thrombomodulin inhibits neutrophil extracellular trap formation in vitro 

      Shimomura, Yasuyo; Suga, Mika; Kuriyama, Naohide; Nakamura, Tomoyuki; Sakai, Toshikazu; Kato, Yu; Hara, Yoshitaka; Yamashita, Chizuru; Nagasaki, Hiroshi; Kaneki, Masao; Nishida, Osamu (BioMed Central, 2016)
      The aim of this study was to investigate the effects of recombinant human-soluble thrombomodulin (rTM) on lipopolysaccharide (LPS)-induced, platelet-dependent neutrophil extracellular trap (NET) formation (NETosis). Human ...
    • Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle 

      Nakazawa, Harumasa; Yamada, Marina; Tanaka, Tomokazu; Kramer, Joshua; Yu, Yong-Ming; Fischman, Alan J.; Martyn, J. A. Jeevendra; Tompkins, Ronald G.; Kaneki, Masao (Public Library of Science, 2015)
      Objective: Metabolic derangements, including insulin resistance and hyperlactatemia, are a major complication of major trauma (e.g., burn injury) and affect the prognosis of burn patients. Protein farnesylation, a ...
    • Suppressive Role of PPARγ-Regulated Endothelial Nitric Oxide Synthase in Adipocyte Lipolysis 

      Yamada, Yoko; Eto, Masato; Ito, Yuki; Mochizuki, Satoru; Son, Bo-Kyung; Ogawa, Sumito; Iijima, Katsuya; Kaneki, Masao; Kozaki, Koichi; Toba, Kenji; Akishita, Masahiro; Ouchi, Yasuyoshi (Public Library of Science, 2015)
      Introduction: Metabolic syndrome causes insulin resistance and is associated with risk factor clustering, thereby increasing the risk of atherosclerosis. Recently, endothelial nitric oxide synthase deficient (eNOS-/-) mice ...
    • Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide Against Neuronal Ischemia 

      Marutani, Eizo; Yamada, Marina; Ida, Tomoaki; Tokuda, Kentaro; Ikeda, Kohei; Kai, Shinichi; Shirozu, Kazuhiro; Hayashida, Kei; Kosugi, Shizuko; Hanaoka, Kenjiro; Kaneki, Masao; Akaike, Takaaki; Ichinose, Fumito (John Wiley and Sons Inc., 2015)
      Background: Hydrogen sulfide (H2S) exhibits protective effects in various disease models including cerebral ischemia–reperfusion (I/R) injury. Nonetheless, mechanisms and identity of molecules responsible for neuroprotective ...
    • Voluntary Exercise Can Ameliorate Insulin Resistance by Reducing iNOS-Mediated S-Nitrosylation of Akt in the Liver in Obese Rats 

      Tsuzuki, Takamasa; Shinozaki, Shohei; Nakamoto, Hideko; Kaneki, Masao; Goto, Sataro; Shimokado, Kentaro; Kobayashi, Hiroyuki; Naito, Hisashi (Public Library of Science, 2015)
      Voluntary exercise can ameliorate insulin resistance. The underlying mechanism, however, remains to be elucidated. We previously demonstrated that inducible nitric oxide synthase (iNOS) in the liver plays an important role ...