Now showing items 1-17 of 17

    • Cell Kinetic Studies Fail to Identify Sequentially Proliferating Progenitors as the Major Source of Epithelial Renewal in the Adult Murine Prostate 

      Pignon, Jean-Christophe; Grisanzio, Chiara; Carvo, Ingrid; Werner, Lillian; Regan, Meredith; Wilson, E. Lynette; Signoretti, Sabina (Public Library of Science, 2015)
      There is evidence that stem cells and their progeny play a role in the development of the prostate. Although stem cells are also considered to give rise to differentiated progeny in the adult prostate epithelium ex vivo, ...
    • Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model 

      Suarez, Eloah Rabello; Chang, De-Kuan; Sun, Jiusong; Sui, Jianhua; Freeman, Gordon J.; Signoretti, Sabina; Zhu, Quan; Marasco, Wayne A. (Impact Journals LLC, 2016)
      Advances in the treatment of metastatic clear cell renal cell carcinoma (ccRCC) have led to improved progression-free survival of many patients; however the therapies are toxic, rarely achieve durable long-term complete ...
    • A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer 

      Lunardi, Andrea; Ala, Ugo; Epping, Mirjam T.; Salmena, Leonardo; Clohessy, John G.; Webster, Kaitlyn A.; Wang, Guocan; Mazzucchelli, Roberta; Bianconi, Maristella; Stack, Edward C.; Lis, Rosina; Patnaik, Akash; Cantley, Lewis C.; Bubley, Glenn; Cordon-Cardo, Carlos; Gerald, William L.; Montironi, Rodolfo; Signoretti, Sabina; Loda, Massimo; Nardella, Caterina; Pandolfi, Pier Paolo (2013)
      Here we report an integrated analysis that leverages data from treatment of genetic mouse models of prostate cancer along with clinical data from patients to elucidate new mechanisms of castration resistance. We show that ...
    • Comprehensive analyses of tumor immunity: implications for cancer immunotherapy 

      Li, Bo; Severson, Eric; Pignon, Jean-Christophe; Zhao, Haoquan; Li, Taiwen; Novak, Jesse; Jiang, Peng; Shen, Hui; Aster, Jon C.; Rodig, Scott; Signoretti, Sabina; Liu, Jun S.; Liu, X. Shirley (BioMed Central, 2016)
      Background: Understanding the interactions between tumor and the host immune system is critical to finding prognostic biomarkers, reducing drug resistance, and developing new therapies. Novel computational methods are ...
    • Correlation of Apobec Mrna Expression with overall Survival and pd-l1 Expression in Urothelial Carcinoma 

      Mullane, Stephanie A.; Werner, Lillian; Rosenberg, Jonathan; Signoretti, Sabina; Callea, Marcella; Choueiri, Toni K.; Freeman, Gordon J.; Bellmunt, Joaquim (Nature Publishing Group, 2016)
      Metastatic urothelial carcinoma (mUC) has a very high mutational rate and is associated with an APOBEC mutation signature. We examined the correlation of APOBEC expression with overall survival (OS) and PD-L1 expression ...
    • Cox-2 Inhibition Enhances the Activity of Sunitinib in Human Renal Cell Carcinoma Xenografts 

      Wang, Xiaoen; Zhang, L; O'Neill, A; Bahamon, B; Alsop, David C.; Mier, James W.; Goldberg, S. Nahum; Signoretti, Sabina; Atkins, M B; Wood, C G; Bhatt, Rupal Satish (Nature Publishing Group, 2013)
      Background: Sunitinib (Su), a tyrosine kinase inhibitor of VEGFR, is effective at producing tumour response in clear cell renal cell carcinoma (cRCC), but resistance to therapy is inevitable. As COX-2 is a known mediator ...
    • Genomic investigation of etiologic heterogeneity: methodologic challenges 

      Begg, Colin B; Seshan, Venkatraman E; Zabor, Emily C; Furberg, Helena; Arora, Arshi; Shen, Ronglai; Maranchie, Jodi K; Nielsen, Matthew E; Rathmell, W Kimryn; Signoretti, Sabina; Tamboli, Pheroze; Karam, Jose A; Choueiri, Toni K; Hakimi, A Ari; Hsieh, James J (BioMed Central, 2014)
      Background: The etiologic heterogeneity of cancer has traditionally been investigated by comparing risk factor frequencies within candidate sub-types, defined for example by histology or by distinct tumor markers of interest. ...
    • High Dose Intermittent Sorafenib Shows Improved Efficacy Over Conventional Continuous Dose in Renal Cell Carcinoma 

      Wang, Xiaoen; Zhang, Liang; Goldberg, S. Nahum; Bhasin, Manoj; Brown, Victoria; Alsop, David C.; Signoretti, Sabina; Mier, James W.; Atkins, Michael B.; Bhatt, Rupal Satish (BioMed Central, 2011)
      Background: Renal cell carcinoma (RCC) responds to agents that inhibit vascular endothelial growth factor (VEGF) pathway. Sorafenib, a multikinase inhibitor of VEGF receptor, is effective at producing tumor responses and ...
    • Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo 

      Chang, De-Kuan; Moniz, Raymond J.; Xu, Zhongyao; Sun, Jiusong; Signoretti, Sabina; Zhu, Quan; Marasco, Wayne A. (BioMed Central, 2015)
      Background: Carbonic anhydrase (CA) IX is a surface-expressed protein that is upregulated by the hypoxia inducible factor (HIF) and represents a prototypic tumor-associated antigen that is overexpressed on renal cell ...
    • Identification of ALK Gene Alterations in Urothelial Carcinoma 

      Bellmunt, Joaquim; Selvarajah, Shamini; Rodig, Scott; Salido, Marta; de Muga, Silvia; Costa, Irmgard; Bellosillo, Beatriz; Werner, Lillian; Mullane, Stephanie; Fay, André P.; O'Brien, Robert; Barretina, Jordi; Minoche, André E.; Signoretti, Sabina; Montagut, Clara; Himmelbauer, Heinz; Berman, David M.; Kantoff, Philip; Choueiri, Toni K.; Rosenberg, Jonathan E. (Public Library of Science, 2014)
      Background: Anaplastic lymphoma kinase (ALK) genomic alterations have emerged as a potent predictor of benefit from treatment with ALK inhibitors in several cancers. Currently, there is no information about ALK gene ...
    • Lrf suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion 

      Wang, Guocan; Lunardi, Andrea; Zhang, Jiangwen; Chen, Zhenbang; Ala, Ugo; Webster, Kaitlyn A.; Tay, Yvonne; Gonzalez-Billalabeitia, Enrique; Egia, Ainara; Shaffer, David R.; Carver, Brett; Liu, Xue-Song; Taulli, Riccardo; Kuo, Winston Patrick; Nardella, Caterina; Signoretti, Sabina; Cordon-Cardo, Carlos; Gerald, William L.; Pandolfi, Pier Paolo (2013)
      Lrf has been previously described as a powerful proto-oncogene. Here we surprisingly demonstrate that Lrf plays a critical oncosuppressive role in the prostate. Prostate specific inactivation of Lrf leads to a dramatic ...
    • A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis 

      Zadra, Giorgia; Photopoulos, Cornelia; Tyekucheva, Svitlana; Heidari, Pedram; Weng, Qing Ping; Fedele, Giuseppe; Liu, Hong; Scaglia, Natalia; Priolo, Carmen; Sicinska, Ewa; Mahmood, Umar; Signoretti, Sabina; Birnberg, Neal; Loda, Massimo (Backwell Publishing Ltd, 2014)
      5′AMP-activated kinase (AMPK) constitutes a hub for cellular metabolic and growth control, thus representing an ideal therapeutic target for prostate cancers (PCas) characterized by increased lipogenesis and activation of ...
    • p63 promotes cell survival through fatty acid synthase 

      Sabbisetti, Venkata S; Di Napoli, Arianna; Seeley, Apryle; Amato, Angela M.; O'Regan, Esther; Ghebremichael, Musie Syum; Loda, Massimo; Signoretti, Sabina (Public Library of Science, 2009)
      There is increasing evidence that p63, and specifically ΔNp63, plays a central role in both development and tumorigenesis by promoting epithelial cell survival. However, few studies have addressed the molecular mechanisms ...
    • Pml Represses Tumour Progression Through Inhibition of mTOR 

      Bernardi, Rosa; Papa, Antonella; Egia, Ainara; Coltella, Nadia; Teruya-Feldstein, Julie; Signoretti, Sabina; Pandolfi, Pier Paolo (Wiley-VCH Verlag Berlin, 2011)
      The promyelocytic leukaemia gene PML is a pleiotropic tumour suppressor. We have recently demonstrated that PML opposes \(mTOR-HIF1\alpha -VEGF\) signalling in hypoxia. To determine the relevance of PML-mTOR antagonism in ...
    • Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study 

      Fay, André P; Signoretti, Sabina; Callea, Marcella; Telό, Gabriela H; McKay, Rana R; Song, Jiaxi; Carvo, Ingrid; Lampron, Megan E; Kaymakcalan, Marina D; Poli-de-Figueiredo, Carlos E; Bellmunt, Joaquim; Hodi, F Stephen; Freeman, Gordon J; Elfiky, Aymen; Choueiri, Toni K (BioMed Central, 2015)
      Background: Adrenocortical carcinoma (ACC) is a rare tumor in which prognostic factors are still not well established. Programmed Death Ligand-1 (PD-L1) expression in ACC and its association with clinico-pathological ...
    • Resistance of Renal Cell Carcinoma to Sorafenib Is Mediated by Potentially Reversible Gene Expression 

      Bhasin, Manoj; Schor-Bardach, Rachel; Collins, Michael P.; Zhang, Liang; Wang, Xiaoen; Panka, David Joel; Putheti, Prabhakar; Signoretti, Sabina; Alsop, David C.; Libermann, Towia Aron; Atkins, Michael B.; Mier, James W.; Goldberg, S. Nahum; Bhatt, Rupal Satish (Public Library of Science, 2011)
      Purpose: Resistance to antiangiogenic therapy is an important clinical problem. We examined whether resistance occurs at least in part via reversible, physiologic changes in the tumor, or results solely from stable genetic ...
    • Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development 

      Giannikou, Krinio; Malinowska, Izabela A.; Pugh, Trevor J.; Yan, Rachel; Tseng, Yuen-Yi; Oh, Coyin; Kim, Jaegil; Tyburczy, Magdalena E.; Chekaluk, Yvonne; Liu, Yang; Alesi, Nicola; Finlay, Geraldine A.; Wu, Chin-Lee; Signoretti, Sabina; Meyerson, Matthew; Getz, Gad; Boehm, Jesse S.; Henske, Elizabeth P.; Kwiatkowski, David J. (Public Library of Science, 2016)
      Renal angiomyolipoma is a kidney tumor in the perivascular epithelioid (PEComa) family that is common in patients with Tuberous Sclerosis Complex (TSC) and Lymphangioleiomyomatosis (LAM) but occurs rarely sporadically. ...