Browsing by Author "Walsh, Dominic"

Now showing items 1-8 of 8

    • Alzheimer's Disease: Synaptic Dysfunction and Aβ 

      Shankar, Ganesh Mani; Walsh, Dominic M. (BioMed Central, 2009)
      Synapse loss is an early and invariant feature of Alzheimer's disease (AD) and there is a strong correlation between the extent of synapse loss and the severity of dementia. Accordingly, it has been proposed that synapse ...

    • Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity 

      Nicoll, Andrew J.; Panico, Silvia; Freir, Darragh B.; Wright, Daniel; Terry, Cassandra; Risse, Emmanuel; Herron, Caroline E.; O’Malley, Tiernan; Wadsworth, Jonathan D. F.; Farrow, Mark A.; Walsh, Dominic M.; Saibil, Helen R.; Collinge, John (Nature Pub. Group, 2013)
      Growing evidence suggests water-soluble, non-fibrillar forms of amyloid-β protein (Aβ) have important roles in Alzheimer’s disease with toxicities mimicked by synthetic Aβ1–42. However, no defined toxic structures acting ...

    • Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo 

      An, Kyongman; Klyubin, Igor; Kim, Youngkyu; Jung, Jung Hoon; Mably, Alexandra J; O’Dowd, Sean T; Lynch, Timothy; Kanmert, Daniel; Lemere, Cynthia A; Finan, Gina M; Park, Joon Won; Kim, Tae-Wan; Walsh, Dominic M; Rowan, Michael J; Kim, Joung-Hun (BioMed Central, 2013)
      Background: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be involved in both the metabolism and aggregation of Alzheimer’s disease (AD)-associated amyloid β-protein (Aβ). Despite their ...

    • A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid 

      Yang, Ting; O’Malley, Tiernan T; Kanmert, Daniel; Jerecic, Jasna; Zieske, Lynn R; Zetterberg, Henrik; Hyman, Bradley T; Walsh, Dominic M; Selkoe, Dennis J (BioMed Central, 2015)
      Introduction: Amyloid β-protein oligomers play a key role in Alzheimer’s disease (AD), but well-validated assays that routinely detect them in cerebrospinal fluid (CSF) are just emerging. We sought to confirm and extend a ...

    • IgG Conformer's Binding to Amyloidogenic Aggregates 

      Phay, Monichan; Welzel, Alfred T.; Williams, Angela D.; McWilliams-Koeppen, Helen P.; Blinder, Veronika; O'Malley, Tiernan T.; Solomon, Alan; Walsh, Dominic M.; O'Nuallain, Brian (Public Library of Science, 2015)
      Amyloid-reactive IgGs isolated from pooled blood of normal individuals (pAbs) have demonstrated clinical utility for amyloid diseases by in vivo targeting and clearing amyloidogenic proteins and peptides. We now report the ...

    • Lessons from a Rare Familial Dementia: Amyloid and Beyond 

      Cantlon, Adam; Frigerio, Carlo Sala; Walsh, Dominic M. (2015)
      Here we review the similarities between a rare inherited disorder, familial British dementia (FBD), and the most common of all late-life neurological conditions, Alzheimer's diseases (AD). We describe the symptoms, pathology ...

    • mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo 

      Hu, Neng-Wei; Nicoll, Andrew J.; Zhang, Dainan; Mably, Alexandra J.; O’Malley, Tiernan; Purro, Silvia A.; Terry, Cassandra; Collinge, John; Walsh, Dominic M.; Rowan, Michael J. (Nature Pub. Group, 2014)
      NMDA-type glutamate receptors (NMDARs) are currently regarded as paramount in the potent and selective disruption of synaptic plasticity by Alzheimer’s disease amyloid β-protein (Aβ). Non-NMDAR mechanisms remain relatively ...

    • Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity 

      Welzel, Alfred T.; Maggio, John E.; Shankar, Ganesh M.; Walker, Donald E.; Ostaszewski, Beth L.; Li, Shaomin; Klyubin, Igor; Rowan, Michael J.; Seubert, Peter; Walsh, Dominic M.; Selkoe, Dennis J. (American Chemical Society, 2014)
      Evidence for a central role of amyloid β-protein (Aβ) in the genesis of Alzheimer’s disease (AD) has led to advanced human trials of Aβ-lowering agents. The “amyloid hypothesis” of AD postulates deleterious effects of ...