Now showing items 1-15 of 15

    • Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls 

      McLaren, Paul J.; Coulonges, Cédric; Ripke, Stephan; van den Berg, Leonard; Buchbinder, Susan; Carrington, Mary; Cossarizza, Andrea; Dalmau, Judith; Deeks, Steven G.; Delaneau, Olivier; De Luca, Andrea; Goedert, James J.; Haas, David; Herbeck, Joshua T.; Kathiresan, Sekar; Kirk, Gregory D.; Lambotte, Olivier; Luo, Ma; Mallal, Simon; van Manen, Daniëlle; Martinez-Picado, Javier; Meyer, Laurence; Miro, José M.; Mullins, James I.; Obel, Niels; O'Brien, Stephen J.; Pereyra, Florencia; Plummer, Francis A.; Poli, Guido; Qi, Ying; Rucart, Pierre; Sandhu, Manj S.; Shea, Patrick R.; Schuitemaker, Hanneke; Theodorou, Ioannis; Vannberg, Fredrik; Veldink, Jan; Walker, Bruce D.; Weintrob, Amy; Winkler, Cheryl A.; Wolinsky, Steven; Telenti, Amalio; Goldstein, David B.; de Bakker, Paul I. W.; Zagury, Jean-François; Fellay, Jacques (Public Library of Science, 2013)
      Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition ...
    • Attenuation of Multiple Nef Functions in HIV-1 Elite Controllers 

      Mwimanzi, Philip; Markle, Tristan J; Martin, Eric; Ogata, Yoko; Kuang, Xiaomei T; Tokunaga, Michiyo; Mahiti, Macdonald; Pereyra, Florencia M.; Miura, Toshiyuki; Walker, Bruce David; Brumme, Zabrina L; Brockman, Mark A; Ueno, Takamasa (BioMed Central, 2013)
      Background: Impaired HIV-1 Gag, Pol, and Env function has been described in elite controllers (EC) who spontaneously suppress plasma viremia to < 50 RNA copies/mL; however, activity of the accessory protein Nef remains ...
    • Blunted Response to Combination Antiretroviral Therapy in HIV Elite Controllers: An International HIV Controller Collaboration 

      Boufassa, Faroudy; Lechenadec, Jérome; Meyer, Laurence; Costagliola, Dominique; Hunt, Peter W.; Pereyra, Florencia; Deeks, Steve; Pancino, Gianfranco; Taulera, Olivier; Lichterfeld, Mathias; Delobel, Pierre; Saez-Cirion, Asier; Lambotte, Olivier (Public Library of Science, 2014)
      Objective: HIV “elite controllers” (ECs) spontaneously control viral load, but some eventually require combination antiretroviral treatment (cART), due to a loss of viral control or a decline in CD4 T-cell counts. Here we ...
    • CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control 

      Mothe, Beatriz; Llano, Anuska; Ibarrondo, Javier; Zamarreño, Jennifer; Schiaulini, Mattia; Miranda, Cristina; Ruiz-Riol, Marta; Berger, Christoph T.; Herrero, M. José; Palou, Eduard; Plana, Montse; Rolland, Morgane; Heckerman, David; Weiner, David; Paredes, Roger; Clotet, Bonaventura; Felber, Barbara K.; Pavlakis, George N.; Mullins, James I.; Brander, Christian; Khatri, Ashok; Pereyra, Florencia M.; Walker, Bruce David (Public Library of Science, 2012)
      Cytotoxic T lymphocyte (CTL) responses targeting specific HIV proteins, in particular Gag, have been associated with relative control of viral replication \(in\) \(vivo\). However, Gag-specific CTL can also be detected in ...
    • Differential Levels of Soluble Inflammatory Markers by Human Immunodeficiency Virus Controller Status and Demographics 

      Li, Jonathan Z.; Arnold, Kelly B.; Lo, Janet; Dugast, Anne-Sophie; Plants, Jill; Ribaudo, Heather J.; Cesa, Kevin; Heisey, Andrea; Kuritzkes, Daniel R.; Lauffenburger, Douglas A.; Alter, Galit; Landay, Alan; Grinspoon, Steven; Pereyra, Florencia (Oxford University Press, 2014)
      Background. Human immunodeficiency virus (HIV)-1 elite controllers (ECs) represent an ideal population to study the effects of HIV persistence on chronic inflammation in the absence of antiretroviral therapy (ART). Methods. ...
    • Elite control of HIV infection: implications for vaccines 

      Miura, Toshiyuki; Rathod, Almas; Baker, Brett; Trocha, Alicja; Ueda, Peggy; Stone, David; Wrin, Terri; Buchbinder, Susan; Petropoulos, Christos J; Pereyra, Florencia M.; Addo, Marylyn Martina; Kaufmann, Daniel; Rosenberg, Rachel; Cohen, Daniel Aaron; Liu, Yang; Rosenberg, Eric Scott; Walker, Bruce David (BioMed Central, 2006)
    • HIV-1 persistence in CD4+ T cells with stem cell-like properties 

      Buzon, Maria J.; Sun, Hong; Li, Chun; Shaw, Amy; Seiss, Katherine; Ouyang, Zhengyu; Martin-Gayo, Enrique; Leng, Jin; Henrich, Timothy J.; Li, Jonathan Z.; Pereyra, Florencia; Zurakowski, Ryan; Walker, Bruce D.; Rosenberg, Eric S.; Yu, Xu G.; Lichterfeld, Mathias (2014)
      Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM) harbor high per-cell levels of HIV-1 ...
    • Interactions between HLA-B and Leukocyte Immunoglobulin like Receptors B2 (LILRB2) Correlate with HIV-1 Disease Outcomes 

      Martin Gayo, Enrique; Jones, D.; Pereyra, Florencia M.; Lichterfeld, Mathias; Allen, R. L.; Yu, X. G. (BioMed Central, 2012)
    • P09-11. Reduced Replication Capacity of NL4-3 Chimeric Viruses Encoding RT-Integrase Sequences from HIV-1 Elite Controllers 

      Brumme, ZL; Miura, T; Rosato, PC; Sela, J; Brumme, CJ; Heckerman, D; Walker, BD; Brockman, Mark; Pereyra, Florencia M.; Li, C (BioMed Central, 2009)
      Background: Spontaneous control of HIV to <50 copies RNA/ml is observed in rare individuals. An improved understanding of this phenomenon may provide insight into host mechanisms that can be modulated for therapeutic benefit ...
    • P16-18. Regulatory T Cell Frequencies Correlate With T Cell Activation in Chronic HIV-1 Infection 

      Pyo, A; Trocha, A; Toth, I; Addo, MM; Angin, Mathieu; Streeck, Hendrik; Pereyra, Florencia M.; Walker, Bruce David; Altfeld, Marcus; Alter, G; Kwon, D; Wen, F (BioMed Central, 2009)
    • Perforin Expression Directly Ex Vivo by HIV-Specific CD8+ T-Cells Is a Correlate of HIV Elite Control 

      Hersperger, Adam R.; Nason, Martha; Demers, Korey; Sheth, Prameet; Shin, Lucy Y.; Kovacs, Colin M.; Rodriguez, Benigno; Sieg, Scott F.; Teixeira-Johnson, Leia; Gudonis, Debbie; Goepfert, Paul A.; Lederman, Michael M.; Makedonas, George; Kaul, Rupert; Betts, Michael R.; Pereyra, Florencia M.; Frank, Ian; Walker, Bruce David (Public Library of Science, 2010)
      Many immune correlates of CD8+ T-cell-mediated control of HIV replication, including polyfunctionality, proliferative ability, and inhibitory receptor expression, have been discovered. However, no functional correlates ...
    • S03-06 OA. Rapid perforin upregulation by CD8 T cells in elite controllers as a correlate of immune-mediated control of HIV replication 

      Hersperger, AR; Demers, K; Sheth, P; Shin, LY; Sieg, SF; Teixeira-Johnson, L; Goepfert, PA; Lederman, MM; Kaul, R; Makedonas, G; Betts, MR; Pereyra, Florencia M.; Rodriguez, B.; Walker, Bruce David (BioMed Central, 2009)
    • Systemic Inhibition of Myeloid Dendritic Cells by Circulating HLA Class I Molecules in HIV-1 Infection 

      Huang, Jinghe; Al-Mozaini, Maha Ahmed; Rogich, Jerome; Carrington, Mary F.; Seiss, Katherine; Pereyra, Florencia M.; Lichterfeld, Mathias; Yu, Xu (BioMed Central, 2012)
      Background: HIV-1 infection is associated with profound dysfunction of myeloid dendritic cells, for reasons that remain ill-defined. Soluble HLA class I molecules can have important inhibitory effects on T cells and NK ...
    • Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection 

      Vaidya, Sagar A; Streeck, Hendrik; Beckwith, Noor; Ghebremichael, Musie; Pereyra, Florencia; Kwon, Douglas S; Addo, Marylyn M; Rychert, Jenna; Routy, Jean-Pierre; Jessen, Heiko; Kelleher, Anthony D; Hecht, Frederick; Sekaly, Rafick-Pierre; Carrington, Mary; Walker, Bruce D; Allen, Todd M; Rosenberg, Eric S; Altfeld, Marcus (BioMed Central, 2013)
      Background: HLA-B alleles are associated with viral control in chronic HIV-1 infection, however, their role in primary HIV-1 disease is unclear. This study sought to determine the role of HLA-B alleles in viral control ...
    • Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection 

      Henn, Matthew R.; Charlebois, Patrick; Lennon, Niall J.; Power, Karen A.; Macalalad, Alexander R.; Berlin, Aaron M.; Malboeuf, Christine M.; Gnerre, Sante; Erlich, Rachel L.; Green, Lisa M.; Berical, Andrew; Wang, Yaoyu; Newman, Ruchi; Axten, Karen L.; Gladden, Adrianne D.; Battis, Laura; Kemper, Michael; Zeng, Qiandong; Shea, Terrance P.; Gujja, Sharvari; Zedlack, Carmen; Gasser, Olivier; Brander, Christian; Günthard, Huldrych F.; Brumme, Zabrina L.; Brumme, Chanson J.; Bazner, Suzane; Rychert, Jenna; Tinsley, Jake P.; Levin, Joshua Z.; Jessen, Heiko; Birren, Bruce W.; Boutwell, Christian Lane; Ryan, Elizabeth M.; Zody, Michael C.; Casali, Monica; Streeck, Hendrik; Bloom, Allyson Kelly; Dudek, Timothy E.; Tully, Damien C.; Hess, Christoph; Mayer, Kenneth Hugh; Rosenberg, Eric Scott; Pereyra, Florencia M.; Young, Sarah K.; Altfeld, Marcus; Walker, Bruce David; Allen, Todd (Public Library of Science, 2012)
      Deep sequencing technologies have the potential to transform the study of highly variable viral pathogens by providing a rapid and cost-effective approach to sensitively characterize rapidly evolving viral quasispecies. ...