Browsing by Author "Lin, Wenyu"

Now showing items 1-4 of 4

    • ARF1 and GBF1 Generate a PI4P-Enriched Environment Supportive of Hepatitis C Virus Replication 

      Zhang, Leiliang; Hong, Zhi; Lin, Wenyu; Shao, Run-Xuan; Goto, Kaku; Hsu, Victor Wee; Chung, Raymond Taeyong (Public Library of Science, 2012)
      Cellular levels of phosphatidylinositol 4-phosphate (PI4P) have been shown to be upregulated during RNA replication of several viruses, including the HCV replicon model. However, whether PI4P is required in an infectious ...

    • HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response 

      Chusri, Pattranuch; Kumthip, Kattareeya; Hong, Jian; Zhu, Chuanlong; Duan, Xiaoqiong; Jilg, Nikolaus; Fusco, Dahlene N.; Brisac, Cynthia; Schaefer, Esperance A.; Cai, Dachuan; Peng, Lee F.; Maneekarn, Niwat; Lin, Wenyu; Chung, Raymond T. (Nature Publishing Group, 2016)
      HCV replication disrupts normal endoplasmic reticulum (ER) function and activates a signaling network called the unfolded protein response (UPR). UPR is directed by three ER transmembrane proteins including ATF6, IRE1, and ...

    • Inhibition of HCV by the serpin antithrombin III 

      Asmal, Mohammed; Seaman, Michael S.; Lin, Wenyu; Chung, Raymond Taeyong; Letvin, Norman L; Geiben-Lynn, Ralf (BioMed Central, 2012)
      Background: Although there have been dramatic strides made recently in the treatment of chronic hepatitis C virus infection, interferon-α based therapy remains challenging for certain populations, including those with ...

    • TRAIL Enhances Apoptosis of Human Hepatocellular Carcinoma Cells Sensitized by Hepatitis C Virus Infection: Therapeutic Implications 

      Jang, Jae Young; Kim, Seong-Jun; Cho, Eun Kyung; Jeong, Soung Won; Park, Eui Ju; Lee, Woong Cheul; Lee, Sae Hwan; Kim, Sang Gyune; Kim, Young Seok; Kim, Hong Soo; Kim, Boo Sung; Lin, Wenyu; Chung, Raymond T. (Public Library of Science, 2014)
      Hepatitis C virus (HCV) infection causes chronic liver diseases leading to hepatocellular carcinoma (HCC) and liver failure. We have previously shown that HCV sensitizes hepatocytes to mitochondrial apoptosis via the TRAIL ...