Browsing by Author "Grandjean, Philippe"
Now showing items 1-20 of 174
-
Adiposity and Glycemic Control in Children Exposed to Perfluorinated Compounds
Timmermann, Clara Amalie G.; Rossing, Laura I.; Grøntved, Anders; Ried-Larsen, Mathias; Dalgård, Christine; Andersen, Lars B.; Grandjean, Philippe; Nielsen, Flemming; Svendsen, Kira D.; Scheike, Thomas; Jensen, Tina K. (The Endocrine Society, 2014)OBJECTIVE: Our objective was to explore whether childhood exposure to perfluorinated and polyfluorinated compounds (PFCs), widely used stain- and grease-repellent chemicals, is associated with adiposity and markers of ... -
Advancing the Science of Developmental Neurotoxicity (DNT): Testing for Better Safety Evaluation
Bal-Price, Anna; Coecke, Sandra; Crofton, Kevin; Fritsche, Ellen; Goldberg, Alan; Grandjean, Philippe; Lein, Pamela; Li, Abby; Lucchini, Roberto; Mundy, William R.; Padilla, Stephanie; Persico, Antonio; Seiler, Andrea; Kreysa, Joachim (ALTEX Edition, 2012) -
Adverse Effects of Methylmercury: Environmental Health Research Implications
Grandjean, Philippe; Satoh, Hiroshi; Murata, Katsuyuki; Eto, Komyo (National Institute of Environmental Health Sciences, 2010)Background: The scientific discoveries of health risks resulting from methylmercury exposure began in 1865 describing ataxia, dysarthria, constriction of visual fields, impaired hearing, and sensory disturbance as symptoms ... -
Allergy and Sensitization during Childhood Associated with Prenatal and Lactational Exposure to Marine Pollutants
Grandjean, Philippe; Poulsen, Lars K.; Heilmann, Carsten; Steuerwald, Ulrike; Weihe, Pál (National Institute of Environmental Health Sciences, 2010)Background: Breast-feeding may affect the risk of developing allergy during childhood and may also cause exposure to immunotoxicants, such as polychlorinated biphenyls (PCBs), which are of concern as marine pollutants in ... -
Alternatives to PFASs: Perspectives on the Science
Birnbaum, Linda S.; Grandjean, Philippe (Environmental Health Perspectives, 2015) -
Antibody response to booster vaccination with tetanus and diphtheria in adults exposed to perfluorinated alkylates
Kielsen, Katrine; Shamim, Zaiba; Ryder, Lars P.; Nielsen, Flemming; Grandjean, Philippe; Budtz-Jørgensen, Esben; Heilmann, Carsten (Informa UK Limited, 2015)Recent studies suggest that exposure to perfluorinated alkylate substances (PFASs) may induce immunosuppression in humans and animal models. In this exploratory study, twelve healthy adult volunteers were recruited. With ... -
Antioxidative enzyme activities in human erythrocytes.
Andersen, HR; Nielsen, JB; Nielsen, F; Grandjean, Philippe (American Association for Clinical Chemistry, 1997)Reliable and standardized methods are necessary to determine the expression of antioxidative enzymes and their role in maintaining health. In addition, the variability of the enzyme activities within the general population ... -
Application of Computational Systems Biology to Explore Environmental Toxicity Hazards
Audouze, Karine; Grandjean, Philippe (National Institute of Environmental Health Sciences, 2011)Background: Computer-based modeling is part of a new approach to predictive toxicology. Objectives: We investigated the usefulness of an integrated computational systems biology approach in a case study involving the isomers ... -
Application of hair-mercury analysis to determine the impact of a seafood advisory
Weihe, Pal; Grandjean, Philippe; Jørgensen, Poul J. (Elsevier BV, 2005)Following an official recommendation in the Faroe Islands that women should abstain from eating mercury-contaminated pilot whale meat, a survey was carried out to obtain information on dietary habits and hair samples for ... -
Assessing Sources of Human Methylmercury Exposure Using Stable Mercury Isotopes
Li, Miling; Sherman, Laura S.; Blum, Joel D.; Grandjean, Philippe; Mikkelsen, Bjarni; Weihe, Pál; Sunderland, Elynor M; Shine, James P. (American Chemical Society (ACS), 2014)Seafood consumption is the primary route of methylmercury (MeHg) exposure for most populations. Inherent uncertainties in dietary survey data point to the need for an empirical tool to confirm exposure sources. We therefore ... -
Assessment of Xenoestrogenic Exposure by a Biomarker Approach: Application of the E-Screen Bioassay to Determine Estrogenic Response of Serum Extracts
Rasmussen, Thomas Høj; Nielsen, Flemming; Andersen, Helle Raun; Nielsen, Jesper Bo; Weihe, Pal; Grandjean, Philippe (BioMed Central, 2003)Background: Epidemiological documentation of endocrine disruption is complicated by imprecise exposure assessment, especially when exposures are mixed. Even if the estrogenic activity of all compounds were known, the ... -
Association Between Child Poverty and Academic Achievement
Oulhote, Youssef; Grandjean, Philippe (American Medical Association (AMA), 2016)Hair et al1 reported in the September 2015 issue of JAMA Pediatrics on the association between child poverty, brain development, and academic achievement. This study provided evidence that as much as 20% of poverty-associated ... -
Association between mercury concentrations in blood and hair in methylmercury-exposed subjects at different ages
Budtz-Jørgensen, Esben; Jørgensen, Poul J; Grandjean, Philippe; Weihe, Pal; Keiding, Niels (Elsevier BV, 2004)Mercury concentrations were measured in paired hair and blood samples from a cohort of about 1000 children examined at birth and at 7 and 14 years of age. The ratio between concentrations in maternal hair (in μg/g) and in ... -
Association between Perfluorinated Compound Exposure and Miscarriage in Danish Pregnant Women
Jensen, Tina Kold; Andersen, Louise Bjørkholt; Kyhl, Henriette Boye; Nielsen, Flemming; Christesen, Henrik Thybo; Grandjean, Philippe (Public Library of Science (PLoS), 2015)Perfluorinated alkylated substances (PFAS) have been extensively used in consumer products and humans are widely exposed to these persistent compounds. A recent study found no association between exposure to perfluorooctanoic ... -
Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination
Timmermann, Clara Amalie Gade; Budtz-Jørgensen, Esben; Jensen, Tina Kold; Osuna, Christa Elyse; Petersen, Maria Skaalum; Steuerwald, Ulrike; Nielsen, Flemming; Poulsen, Lars K.; Weihe, Pal; Grandjean, Philippe (Informa UK Limited, 2017)Perfluoroalkyl substances (PFAS) are highly persistent chemicals that might be associated with asthma and allergy, but the associations remain unclear. Therefore, this study examined whether pre- and post-natal PFAS exposure ... -
Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1–4years among 359 children in the Odense Child Cohort
Dalsager, Louise; Christensen, Nikolas; Husby, Steffen; Kyhl, Henriette; Nielsen, Flemming; Høst, Arne; Grandjean, Philippe; Jensen, Tina Kold (Elsevier BV, 2016)Perfluorinated alkylated substances (PFAS) are persistent industrial chemicals that have resulted in global environmental exposures. Previous epidemiological studies have reported possible effects on the immune system after ... -
Association of lifetime exposure to fluoride and cognitive functions in Chinese children: A pilot study
Choi, Anna L.; Zhang, Ying; Sun, Guifan; Bellinger, David C; Wang, Kanglin; Yang, Xiao Jing; Li, Jin Shu; Zheng, Quanmei; Fu, Yuanli; Grandjean, Philippe (Elsevier BV, 2015)Background A systematic review and meta-analysis of published studies on developmental fluoride neurotoxicity support the hypothesis that exposure to elevated concentrations of fluoride in water is neurotoxic during ... -
Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption
Mahaffey, Kathryn R; Sunderland, Elynor M; Chan, Hing Man; Choi, Anna; Grandjean, Philippe; Mariën, Koenraad; Oken, Emily; Sakamoto, Mineshi; Schoeny, Rita; Weihe, Pál; Yan, Chong-Huai; Yasutake, Akira (Oxford University Press (OUP), 2011)Fish and shellfish are widely available foods that provide important nutrients, particularly n-3 polyunsaturated fatty acids (n-3 PUFAs), to many populations globally. These nutrients, especially docosahexaenoic acid, ... -
Behavioral difficulties in 7-year old children in relation to developmental exposure to perfluorinated alkyl substances
Oulhote, Youssef; Steuerwald, Ulrike; Debes, Frodi; Weihe, Pal; Grandjean, Philippe (Elsevier BV, 2016)Background: Perfluorinated alkyl substances (PFAS) are suspected endocrine disruptors that are highly persistent and neurotoxic in animals. Human epidemiological studies of exposure-related deviations of children’s behaviors ... -
Benchmark Dose Calculation from Epidemiological Data
Budtz-Jørgensen, Esben; Keiding, Niels; Grandjean, Philippe (Wiley, 2001-09)A threshold for dose-dependent toxicity is crucial for standards setting but may not be possible to specify from empirical studies. Crump (1984) instead proposed calculating the lower statistical confidence bound of the ...