Browsing by Author "Novak, Vera"
Now showing items 1-17 of 17
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Association of Blood Pressure Elevation and Nocturnal Dipping With Brain Atrophy, Perfusion and Functional Measures in Stroke and Nonstroke Individuals
Hajjar, Ihab; Zhao, Peng; Alsop, David; Abduljalil, Amir; Selim, Magdy; Novak, Peter; Novak, Vera (Oxford University Press (OUP), 2010-01)Background Although blood pressure elevation and lower nocturnal dipping both increase vascular risk, it is not known if either or both are also associated with brain atrophy, cerebral perfusion, and functional ... -
Association of Statins with Sensory and Autonomic Ganglionopathy
Novak, Peter; Pimentel, Daniela A.; Sundar, Banu; Moonis, Majaz; Qin, Lan; Novak, Vera (Frontiers Media S.A., 2015)Objective: To examine if statins have an effect on small nerve fibers. Methods: This retrospective study evaluated the effect of statins in pure small-fiber neuropathy (SFN). Outcome measures were symptom scales (numbness, ... -
Cerebral Blood Flow Velocity and Periventricular White Matter Hyperintensities in Type 2 Diabetes
Novak, Vera; Last, David; Alsop, David; Abduljalil, Amir; Hu, Kun; Lepicovsky, Lukas; Cavallerano, Jerry; Lipsitz, Lewis (American Diabetes Association, 2006-07)OBJECTIVE Diabetes increases the risk for cerebromicrovascular disease, possibly through its effects on blood flow regulation. The aim of this study was to assess the effects of type 2 diabetes on blood flow velocities ... -
Complexity-Based Measures Inform Effects of Tai Chi Training on Standing Postural Control: Cross-Sectional and Randomized Trial Studies
Wayne, Peter M.; Gow, Brian J.; Costa, Madalena D.; Peng, C.-K.; Lipsitz, Lewis A.; Hausdorff, Jeffrey M.; Davis, Roger B.; Walsh, Jacquelyn N.; Lough, Matthew; Novak, Vera; Yeh, Gloria Y.; Ahn, Andrew C.; Macklin, Eric A.; Manor, Brad (Public Library of Science, 2014)Background: Diminished control of standing balance, traditionally indicated by greater postural sway magnitude and speed, is associated with falls in older adults. Tai Chi (TC) is a multisystem intervention that reduces ... -
Effect of step-synchronized vibration stimulation of soles on gait in Parkinson's disease: a pilot study
Novak, Peter; Novak, Vera (BioMed Central, 2006)Background: Previous studies have suggested that impaired proprioceptive processing in the striatum may contribute to abnormal gait in Parkinson's disease (PD). Methods: This pilot study assessed the effects of enhanced ... -
Enhancement of Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes
Novak, Vera; Milberg, William; Hao, Ying; Munshi, Medha; Novak, Peter; Galica, Andrew; Manor, Bradley; Roberson, Paula; Craft, Suzanne; Abduljalil, Amir (American Diabetes Association, 2014)OBJECTIVE To determine acute effects of intranasal insulin on regional cerebral perfusion and cognition in older adults with type 2 diabetes mellitus (DM). RESEARCH DESIGN AND METHODS This was a proof-of-concept, randomized, ... -
Foot Pressure Distribution During Walking in Young and Old Adults
Hessert, Mary Josephine; Vyas, Mitul; Leach, Jason; Hu, Kun; Lipsitz, Lewis Arnold; Novak, Vera (BioMed Central, 2005)Background: Measurement of foot pressure distribution (FPD) is clinically useful for evaluation of foot and gait pathologies. The effects of healthy aging on FPD during walking are not well known. This study evaluated FPD ... -
Global and Regional Effects of Type 2 Diabetes on Brain Tissue Volumes and Cerebral Vasoreactivity
Last, David; Alsop, David; Abduljalil, Amir; Marquis, Robert P.; de Bazelaire, Cedric; Hu, Kun; Cavallerano, Jerry; Novak, Vera (American Diabetes Association, 2007-02-08)OBJECTIVE—The aim of this study was to evaluate the regional effects of type 2 diabetes and associated conditions on cerebral tissue volumes and cerebral blood flow (CBF) regulation. RESEARCH DESIGN AND METHODS—CBF was ... -
Hypertension and Cerebral Vasoreactivity
Hajjar, Ihab; Zhao, Peng; Alsop, David; Novak, Vera (Ovid Technologies (Wolters Kluwer Health), 2010-11)Hypertension is associated with microvascular and macrovascular brain injury but its direct influence on the cerebral circulation is not fully clear. Our objective was to investigate the association of hypertension with ... -
Impaired Cerebral Autoregulation Is Associated with Brain Atrophy and Worse Functional Status in Chronic Ischemic Stroke
Aoi, Mikio C.; Hu, Kun; Lo, Men-Tzung; Selim, Magdy H.; Olufsen, Mette S.; Novak, Vera (Public Library of Science, 2012)Dynamic cerebral autoregulation (dCA) is impaired following stroke. However, the relationship between dCA, brain atrophy, and functional outcomes following stroke remains unclear. In this study, we aimed to determine whether ... -
Multi-Scale Glycemic Variability: A Link to Gray Matter Atrophy and Cognitive Decline in Type 2 Diabetes
Cui, Xingran; Abduljalil, Amir; Manor, Brad D.; Peng, Chung-Kang; Novak, Vera (Public Library of Science, 2014)Objective: Type 2 diabetes mellitus (DM) accelerates brain aging and cognitive decline. Complex interactions between hyperglycemia, glycemic variability and brain aging remain unresolved. This study investigated the ... -
Multimodal Pressure-Flow Method to Assess Dynamics of Cerebral Autoregulation in Stroke and Hypertension
Novak, Vera; Yang, Albert CC; Lepicovsky, Lukas; Goldberger, Ary Louis; Lipsitz, Lewis Arnold; Peng, Chung-Kang (BioMed Central, 2004)Background: This study evaluated the effects of stroke on regulation of cerebral blood flow in response to fluctuations in systemic blood pressure (BP). The autoregulatory dynamics are difficult to assess because of the ... -
A Nonlinear Dynamic Approach Reveals a Long-Term Stroke Effect on Cerebral Blood Flow Regulation at Multiple Time Scales
Hu, Kun; Lo, Men-Tzung; Peng, Chung-Kang; Liu, Yanhui; Novak, Vera (Public Library of Science, 2012)Cerebral autoregulation (CA) is an important vascular control mechanism responsible for relatively stable cerebral blood flow despite changes of systemic blood pressure (BP). Impaired CA may leave brain tissue unprotected ... -
The Rationale and Design of the Antihypertensives and Vascular, Endothelial, and Cognitive Function (AVEC)Trial in Elderly Hypertensives with Early Cognitive Impairment: Role of the Renin Angiotensin System Inhibition
Hajjar, Ihab; Hart, Meaghan; Milberg, William Paul; Novak, Vera; Lipsitz, Lewis Arnold (BioMed Central, 2009)Background: Prior evidence suggests that the renin angiotensin system and antihypertensives that inhibit this system play a role in cognitive, central vascular, and endothelial function. Our objective is to conduct a ... -
Slow gait speed – an indicator of lower cerebral vasoreactivity in type 2 diabetes mellitus
Jor’dan, Azizah J.; Manor, Brad; Novak, Vera (Frontiers Media S.A., 2014)Objective: Gait speed is an important predictor of health that is negatively affected by aging and type 2 diabetes. Diabetes has been linked to reduced vasoreactivity, i.e., the capacity to regulate cerebral blood flow in ... -
Tai Chi Training may Reduce Dual Task Gait Variability, a Potential Mediator of Fall Risk, in Healthy Older Adults: Cross-Sectional and Randomized Trial Studies
Wayne, Peter M.; Hausdorff, Jeffrey M.; Lough, Matthew; Gow, Brian J.; Lipsitz, Lewis; Novak, Vera; Macklin, Eric A.; Peng, Chung-Kang; Manor, Brad (Frontiers Media S.A., 2015)Background: Tai Chi (TC) exercise improves balance and reduces falls in older, health-impaired adults. TC’s impact on dual task (DT) gait parameters predictive of falls, especially in healthy active older adults, however, ... -
White Matter Hyperintensities and Dynamics of Postural Control
Novak, Vera; Haertle, Mareile; Zhao, Peng; Hu, Kun; Munshi, Medha; Novak, Peter; Abduljalil, Amir; Alsop, David (Elsevier BV, 2009-07)Background White matter hyperintensities (WMHs) on MRI have been associated with age, cardiovascular risk factors and falls in the elderly. This study evaluated the relationship between WMHs and dynamics of postural control ...