Now showing items 1-10 of 10

    • Characterizing the Infection-Induced Transcriptome of Nasonia vitripennis Reveals a Preponderance of Taxonomically-Restricted Immune Genes 

      Sackton, Timothy B.; Werren, John H.; Clark, Andrew G. (Public Library of Science, 2013)
      The innate immune system in insects consists of a conserved core signaling network and rapidly diversifying effector and recognition components, often containing a high proportion of taxonomically-restricted genes. In the ...
    • Comparative Profiling of the Transcriptional Response to Infection in Two Species of Drosophila by Short-read cDNA Sequencing 

      Sackton, Timothy; Clark, Andrew G. (BioMed Central, 2009)
      Background: Homology-based comparisons of the genes involved in innate immunity across many insect taxa with fully sequenced genomes has revealed a striking pattern of gene gain and loss, particularly among genes that ...
    • Genes Involved in the Evolution of Herbivory by a Leaf-Mining, Drosophilid Fly 

      Whiteman, Noah K.; Gloss, Andrew D.; Sackton, Timothy; Groen, Simon C.; Humphrey, Parris T.; Lapoint, Richard T.; Sønderby, Ida E.; Halkier, Barbara A.; Kocks, Christine; Ausubel, Frederick M.; Pierce, Naomi Ellen (Oxford University Press (OUP), 2012)
      Herbivorous insects are among the most successful radiations of life. However, we know little about the processes underpinning the evolution of herbivory. We examined the evolution of herbivory in the fly, Scaptomyza flava, ...
    • Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment 

      Scott, Jeffrey G; Warren, Wesley C; Beukeboom, Leo W; Bopp, Daniel; Clark, Andrew G; Giers, Sarah D; Hediger, Monika; Jones, Andrew K; Kasai, Shinji; Leichter, Cheryl A; Li, Ming; Meisel, Richard P; Minx, Patrick; Murphy, Terence D; Nelson, David R; Reid, William R; Rinkevich, Frank D; Robertson, Hugh M; Sackton, Timothy B; Sattelle, David B; Thibaud-Nissen, Francoise; Tomlinson, Chad; van de Zande, Louis; Walden, Kimberly KO; Wilson, Richard K; Liu, Nannan (BioMed Central, 2014)
      Background: Adult house flies, Musca domestica L., are mechanical vectors of more than 100 devastating diseases that have severe consequences for human and animal health. House fly larvae play a vital role as decomposers ...
    • Meta-Analysis Reveals that Genes Regulated by the Y Chromosome in Drosophila melanogaster Are Preferentially Localized to Repressive Chromatin 

      Sackton, Timothy; Hartl, Daniel L. (Oxford University Press, 2013)
      The Drosophila Y chromosome is a degenerated, heterochromatic chromosome with few functional genes. Despite this, natural variation on the Y chromosome in D. melanogaster has substantial trans-acting effects on the regulation ...
    • Natural Selection Constrains Neutral Diversity across A Wide Range of Species 

      Corbett-Detig, Russell B.; Hartl, Daniel L.; Sackton, Timothy B. (Public Library of Science, 2015)
      The neutral theory of molecular evolution predicts that the amount of neutral polymorphisms within a species will increase proportionally with the census population size (Nc). However, this prediction has not been borne ...
    • OGS2: genome re-annotation of the jewel wasp Nasonia vitripennis 

      Rago, Alfredo; Gilbert, Donald G.; Choi, Jeong-Hyeon; Sackton, Timothy B.; Wang, Xu; Kelkar, Yogeshwar D.; Werren, John H.; Colbourne, John K. (BioMed Central, 2016)
      Background: Nasonia vitripennis is an emerging insect model system with haplodiploid genetics. It holds a key position within the insect phylogeny for comparative, evolutionary and behavioral genetic studies. The draft ...
    • Population Genomic Inferences from Sparse High-Throughput Sequencing of Two Populations of Drosophila melanogaster 

      Sackton, Timothy; Kulathinal, Rob J.; Bergman, Casey M.; Quinlan, Aaron R.; Dopman, Erik B.; Carneiro, Mauricio Oliveira; Marth, Gabor T.; Hartl, Daniel L.; Clark, Andrew G. (Oxford University Press, 2009)
      Short-read sequencing techniques provide the opportunity to capture genome-wide sequence data in a single experiment. A current challenge is to identify questions that shallow-depth genomic data can address successfully ...
    • Positive Selection Drives Faster-Z Evolution in Silkmoths 

      Sackton, Timothy; Corbett-Detig, Russell B.; Nagaraju, Javaregowda; Vaishna, Lakshmi; Arunkumar, Kallare P.; Hartl, Daniel L. (Wiley-Blackwell, 2014)
      Genes linked to X or Z chromosomes, which are hemizygous in the heterogametic sex, are predicted to evolve at different rates than those on autosomes. This “faster-X effect” can arise either as a consequence of hemizygosity, ...
    • Y Chromosome Mediates Ribosomal DNA Silencing and Modulates the Chromatin State in Drosophila 

      Zhou, Jun; Sackton, Timothy; Martinsen, Lene; Silva, Bernardo Lemos; Eickbush, Thomas H.; Hartl, Daniel L. (Proceedings of the National Academy of Sciences, 2012)
      Although the Drosophila Y chromosome is degenerated, heterochromatic, and contains few genes, increasing evidence suggests that it plays an important role in regulating the expression of numerous autosomal and X-linked ...