Now showing items 1-4 of 4

    • Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis 

      Weiner, Brian; Raman, Sahadevan; Dolganov, Gregory; Peterson, Matthew; Riley, Robert; Abeel, Thomas; White, Jared; Sisk, Peter; Stolte, Christian; Koehrsen, Mike; Yamamoto, Robert T; Iacobelli-Martinez, Milena; Kidd, Matthew J; Maer, Andreia M; Schoolnik, Gary K; Regev, Aviv; McGuire, Abigail Manson; Park, Sang T.; Wapinski, Ilan Neustat; Zucker, Jeremy Daniel Hofeld; Galagan, James E. (BioMed Central, 2012)
      Background: The sequence of the pathogen Mycobacterium tuberculosis (Mtb) strain H37Rv has been available for over a decade, but the biology of the pathogen remains poorly understood. Genome sequences from other Mtb strains ...
    • Evolutionary principles of modular gene regulation in yeasts 

      Thompson, Dawn A; Roy, Sushmita; Chan, Michelle; Styczynsky, Mark P; Pfiffner, Jenna; French, Courtney; Socha, Amanda; Thielke, Anne; Napolitano, Sara; Muller, Paul; Kellis, Manolis; Konieczka, Jay H; Wapinski, Ilan; Regev, Aviv (eLife Sciences Publications, Ltd, 2013)
      Divergence in gene regulation can play a major role in evolution. Here, we used a phylogenetic framework to measure mRNA profiles in 15 yeast species from the phylum Ascomycota and reconstruct the evolution of their modular ...
    • A Functional Selection Model Explains Evolutionary Robustness Despite Plasticity in Regulatory Networks 

      Habib, Naomi; Wapinski, Ilan Neustat; Margalit, Hanah; Regev, Aviv; Friedman, Nir (Nature Publishing Group, 2012)
      Evolutionary rewiring of regulatory networks is an important source of diversity among species. Previous evidence suggested substantial divergence of regulatory networks across species. However, systematically assessing ...
    • Proto-genes and De Novo Gene Birth 

      Carvunis, Anne-Ruxandra; Rolland, Thomas; Wapinski, Ilan Neustat; Calderwood, Michael A; Yildirim, Muhammed A.; Simonis, Nicolas; Charloteaux, Benoit; Hidalgo, César A.; Barbette, Justin; Santhanam, Balaji; Brar, Gloria A.; Weissman, Jonathan S.; Regev, Aviv; Thierry-Mieg, Nicolas; Cusick, Michael; Vidal, Marc (Nature Publishing Group, 2012)
      Novel protein-coding genes can arise either through re-organization of pre-existing genes or de novo. Processes involving re-organization of pre-existing genes, notably following gene duplication, have been extensively ...