Now showing items 1-6 of 6

    • Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV 

      Grishchuk, Yulia; Sri, Sarmi; Rudinskiy, Nikita; Ma, Weiyuan; Stember, Katherine G; Cottle, Matthew W; Sapp, Ellen; Difiglia, Marian; Muzikansky, Alona; Betensky, Rebecca A; Wong, Andrew M S; Bacskai, Brian J; Hyman, Bradley T; Kelleher, Raymond J; Cooper, Jonathan D; Slaugenhaupt, Susan A (BioMed Central, 2014)
      Mucolipidosis IV (MLIV) is caused by mutations in the gene MCOLN1. Patients with MLIV have severe neurologic deficits and very little is known about the brain pathology in this lysosomal disease. Using an accurate mouse ...
    • In Vivo Detection of Amyloid-\(\beta\) Deposits Using Heavy Chain Antibody Fragments in a Transgenic Mouse Model for Alzheimer's Disease 

      Nabuurs, Rob J. A.; Rutgers, Kim S.; Welling, Mick M.; Metaxas, Athanasios; de Backer, Maaike E.; Rotman, Maarten; Bacskai, Brian; van Buchem, Mark A.; van der Maarel, Silvère M.; van der Weerd, Louise (Public Library of Science, 2012)
      This study investigated the in vivo properties of two heavy chain antibody fragments (V\(_H\)H), ni3A and pa2H, to differentially detect vascular or parenchymal amyloid-\(\beta\) deposits characteristic for Alzheimer's ...
    • PEG-Like Nanoprobes: Multimodal, Pharmacokinetically and Optically Tunable Nanomaterials 

      Guo, Yanyan; Yuan, Hushan; Claudio, Natalie M.; Kura, Sreekanth; Shakerdge, Naomi; Mempel, Thorsten R.; Bacskai, Brian J.; Josephson, Lee (Public Library of Science, 2014)
      “PEG-like Nanoprobes” (PN’s) are pharmacokinetically and optically tunable nanomaterials whose disposition in biological systems can be determined by fluorescence or radioactivity. PN’s feature a unique design where a ...
    • Tau Causes Synapse Loss without Disrupting Calcium Homeostasis in the rTg4510 Model of Tauopathy 

      Kopeikina, Katherine J.; Wegmann, Susanne; Pitstick, Rose; Carlson, George A.; Bacskai, Brian J.; Betensky, Rebecca A.; Hyman, Bradley T.; Spires-Jones, Tara L. (Public Library of Science, 2013)
      Neurofibrillary tangles (NFTs) of tau are one of the defining hallmarks of Alzheimer’s disease (AD), and are closely associated with neuronal degeneration. Although it has been suggested that calcium dysregulation is ...
    • Time-Domain Fluorescence Diffuse Optical Tomography: Algorithms and Applications 

      Hou, Steven Shuyu (2014-10-21)
      Fluorescence diffuse optical tomography provides non-invasive, in vivo imaging of molecular targets in small animals. While standard fluorescence microscopy is limited to shallow depths and small fields of view, tomographic ...
    • Ultrasound Enhanced Delivery of Molecular Imaging and Therapeutic Agents in Alzheimer's Disease Mouse Models 

      Raymond, Scott Bruce; Treat, Lisa H.; Dewey, Jonathan D.; McDannold, Nathan Judson; Hynynen, Kullervo; Bacskai, Brian (Public Library of Science, 2008)
      Alzheimer's disease is a neurodegenerative disorder typified by the accumulation of a small protein, beta-amyloid, which aggregates and is the primary component of amyloid plaques. Many new therapeutic and diagnostic agents ...