Now showing items 1-12 of 12

    • Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication 

      Annes, J. P.; Ryu, J. H.; Lam, K.; Carolan, Peter Joseph; Utz, K.; Hollister-Lock, J.; Anthony, Anthony; Rubin, Lee; Weir, Gordon Campbell; Melton, Douglas A. (Proceedings of the National Academy of Sciences, 2012)
      Diabetes is a pathological condition characterized by relative insulin deficiency, persistent hyperglycemia, and, consequently, diffuse micro- and macrovascular disease. One therapeutic strategy is to amplify insulin-secretion ...
    • Dynamic development of the pancreas from birth to adulthood 

      Bonner-Weir, Susan; Weir, Gordon C.; Aguayo-Mazzucato, Cristina (Taylor & Francis, 2016)
      After birth the endocrine pancreas continues its development, a complex process that involves both the maturation of islet cells and a marked expansion of their numbers. New beta cells are formed both by duplication of ...
    • Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes 

      Marselli, Lorella; Thorne, Jeffrey; Dahiya, Sonika; Sgroi, Dennis Charles; Sharma, Arun J.; Bonner-Weir, Susan; Weir, Gordon Campbell; Marchetti, Piero (Public Library of Science, 2010)
      Background: Changes in gene expression in pancreatic beta-cells from type 2 diabetes (T2D) should provide insights into their abnormal insulin secretion and turnover. Methodology/Principal Findings: Frozen sections were ...
    • Islet β cell mass in diabetes and how it relates to function, birth, and death 

      Weir, Gordon C; Bonner-Weir, Susan (Blackwell Publishing Ltd, 2013)
      In type 1 diabetes (T1D) β cell mass is markedly reduced by autoimmunity. Type 2 diabetes (T2D) results from inadequate β cell mass and function that can no longer compensate for insulin resistance. The reduction of β cell ...
    • Per-arnt-sim (PAS) Domain-Containing Protein Kinase Is Downregulated in Human Islets in Type 2 Diabetes and Regulates Glucagon Secretion 

      Farhan, H.; Caxaria, S.; Bugliani, M.; Marselli, L.; Marchetti, P.; Birzele, F.; Scharfmann, R.; Rutter, J.; Siniakowicz, K.; Reimann, F.; Gribble, F. M.; Rutter, G. A.; Kim, H.; Johnson, P.; Weir, Gordon Campbell; Hughes, S.; Sun, G.; Parker, H. (Springer-Verlag, 2010)
      Aims/hypothesis We assessed whether per-arnt-sim (PAS) domain-containing protein kinase (PASK) is involved in the regulation of glucagon secretion. Methods mRNA levels were measured in islets by quanti- tative PCR and in ...
    • Protective Unfolded Protein Response in Human Pancreatic Beta Cells Transplanted into Mice 

      Kennedy, Jeffrey; Katsuta, Hitoshi; Jung, Min-Ho; Marselli, Lorella; Goldfine, Allison Braunwald; Balis, Ulysses J.; Sgroi, Dennis Charles; Bonner-Weir, Susan; Weir, Gordon Campbell (Public Library of Science, 2010)
      Background: There is great interest about the possible contribution of ER stress to the apoptosis of pancreatic beta cells in the diabetic state and with islet transplantation. Methods and Findings: Expression of genes ...
    • Stem cell approaches for diabetes: towards beta cell replacement 

      Weir, Gordon Campbell; Cavelti-Weder, Claudia Regula; Bonner-Weir, Susan (BioMed Central, 2011)
      Stem cells hold great promise for pancreatic beta cell replacement therapy for diabetes. In type 1 diabetes, beta cells are mostly destroyed, and in type 2 diabetes beta cell numbers are reduced by 40% to 60%. The ...
    • Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes 

      King, Aileen J. F.; Guo, Yongjing; Cai, Dongsheng; Hollister-Lock, Jennifer; Morris, Brooke; Salvatori, Alison; Corbett, John A.; Bonner-Weir, Susan; Weir, Gordon C.; Shoelson, Steven E. (Public Library of Science, 2013)
      The activation of the transcription factor NF-κB leads to changes in expression of many genes in pancreatic β-cells. However, the role of NF-κB activation in islet transplantation has not been fully elucidated. The aim of ...
    • Thyroid Hormone Promotes Postnatal Rat Pancreatic β-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA 

      Aguayo-Mazzucato, Cristina; Zavacki, Ann Marie; Marinelarena, Alejandra; Hollister-Lock, Jennifer; El Khattabi, Ilham; Marsili, Alessandro; Weir, Gordon C.; Sharma, Arun; Larsen, P. Reed; Bonner-Weir, Susan (American Diabetes Association, 2013)
      Neonatal β cells do not secrete glucose-responsive insulin and are considered immature. We previously showed the transcription factor MAFA is key for the functional maturation of β cells, but the physiological regulators ...
    • β-cell dedifferentiation in diabetes is important, but what is it? 

      Weir, Gordon C; Aguayo-Mazzucato, Cristina; Bonner-Weir, Susan (Landes Bioscience, 2013)
      This commentary discusses the concept of β-cell dedifferentiation in diabetes, which is important but not well defined. A broad interpretation is that a state of differentiation has been lost, which means changes in gene ...
    • β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment 

      Halban, Philippe A.; Polonsky, Kenneth S.; Bowden, Donald W.; Hawkins, Meredith A.; Ling, Charlotte; Mather, Kieren J.; Powers, Alvin C.; Rhodes, Christopher J.; Sussel, Lori; Weir, Gordon C. (American Diabetes Association, 2014)
      OBJECTIVE This article examines the foundation of β-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention and treatment. RESEARCH ...
    • β-Cell Growth and Regeneration: Replication is Only Part of the Story 

      Bonner-Weir, Susan; Weir, Gordon Campbell; Li, Wan-Chun; Ouziel-Yahalom, Limor; Guo, Lili; Sharma, Arun J. (American Diabetes Association, 2010)