Browsing by Author "Frank, Markus"
Now showing items 1-3 of 3
-
Circulating Melanoma Cell Subpopulations: Their Heterogeneity and Differential Responses to Treatment
Gray, Elin S; Reid, Anna L; Bowyer, Samantha; Calapre, Leslie; Siew, Kelvin; Pearce, Robert; Cowell, Lester; Frank, Markus H; Millward, Michael; Ziman, Mel (Nature Publishing Group, 2015)Metastatic melanoma is a highly heterogeneous tumor; thus, methods to analyze tumor-derived cells circulating in blood should address this diversity. Taking this into account, we analyzed, using multiparametric flow ... -
Expression of Cell-Surface Marker ABCB5 Causes Characteristic Modifications of Glucose, Amino Acid and Phospholipid Metabolism in the G3361 Melanoma-Initiating Cell Line
Lutz, Norbert W.; Banerjee, Pallavi; Wilson, Brian J.; Ma, Jie; Cozzone, Patrick J.; Frank, Markus H. (Public Library of Science, 2016)We present a pilot study aimed at determining the effects of expression of ATP-binding cassette member B5 (ABCB5), a previously described marker for melanoma-initiating cells, on cellular metabolism. Metabolic profiles for ... -
Nestin depletion induces melanoma matrix metalloproteinases and invasion
Lee, Chung-Wei; Zhan, Qian; Lezcano, Cecilia; Frank, Markus H.; Huang, John; Larson, Allison; Lin, Jennifer Y.; Wan, Marilyn T.; Lin, Ping-I; Ma, Jie; Kleffel, Sonja; Schatton, Tobias; Lian, Christine G.; Murphy, George F. (2015)Matrix metalloproteinases (MMPs) are key biological mediators of processes as diverse as wound healing, embryogenesis, and cancer progression. Although MMPs may be induced through multiple signaling pathways, the precise ...