Browsing by Author "Litonjua, Augusto A."

Now showing items 1-20 of 37

    • Air Pollution and ST-Segment Depression in Elderly Subjects 

      MacCallum, Gail; Canner, Marina J.; Gold, Diane R.; Litonjua, Augusto Ampil; Zanobetti, Antonella; Coull, Brent Andrew; Schwartz, Joel David; Verrier, Richard Leonard; Nearing, Bruce David; Suh MacIntosh, Helen H.; Stone, Peter Howard (National Institue of Environmental Health Sciences, 2005)
      Increased levels of daily ambient particle pollution have been associated with increased risk of cardiovascular morbidity. Black carbon (BC) is a measure of the traffic-related component of particles. We investigated ...

    • Alu and LINE-1 methylation and lung function in the normative ageing study 

      Lange, Nancy E; Sordillo, Joanne; Tarantini, Letizia; Bollati, Valentina; Sparrow, David; Vokonas, Pantel; Zanobetti, Antonella; Schwartz, Joel David; Baccarelli, Andrea; Litonjua, Augusto Ampil; Demeo, Dawn Lisa (BMJ Publishing Group, 2012)
      Objectives: To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. Design: Cohort study. Setting: Outpatient Veterans Administration ...

    • Association between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study 

      Lampe, Brad J.; Park, Sung Kyun; Robins, Thomas; Mukherjee, Bhramar; Litonjua, Augusto Ampil; Amarasiriwardena, Chitra J.; Weisskopf, Marc G.; Sparrow, David; Hu, Howard (National Institute of Environmental Health Sciences, 2008)
      Background: High levels of cadmium exposure are known to cause emphysema in occupationally exposed workers, but little has been reported to date on the association between chronic environmental cadmium exposure and pulmonary ...

    • Associations of Toenail Arsenic, Cadmium, Mercury, Manganese, and Lead with Blood Pressure in the Normative Aging Study 

      Mordukhovich, Irina; Wright, Robert O.; Hu, Howard; Amarasiriwardena, Chitra J.; Baccarelli, Andrea; Litonjua, Augusto Ampil; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2012)
      Background: Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. ...

    • Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood 

      Agha, Golareh; Hajj, Hanine; Rifas-Shiman, Sheryl L.; Just, Allan C.; Hivert, Marie-France; Burris, Heather H.; Lin, Xihong; Litonjua, Augusto A.; Oken, Emily; DeMeo, Dawn L.; Gillman, Matthew W.; Baccarelli, Andrea A. (BioMed Central, 2016)
      Background: Both higher and lower fetal growth are associated with cardio-metabolic health later in life, suggesting that prenatal developmental programming determines long-term cardiovascular disease risk. Epigenetic ...

    • Comprehensive Genetic Assessment of a Functional TLR9 Promoter Polymorphism: No Replicable Association with Asthma or Asthma-Related Phenotypes 

      Avila, Lydiana; Hawrylowicz, Catherine M; Lange, Nancy Elizabeth; Zhou, Xiaobo; Su, Jessica Ann Lasky; Himes, Blanca Elena; Lazarus, Ross; Raby, Benjamin Alexander; Litonjua, Augusto Ampil; Soto-Quiros, Manuel; Celedon, Juan C (BioMed Central, 2011)
      Background: Prior studies suggest a role for a variant (rs5743836) in the promoter of toll-like receptor 9 (TLR9) in asthma and other inflammatory diseases. We performed detailed genetic association studies of the functional ...

    • Corticosteroid use and bone mineral accretion in children with asthma: Effect modification by vitamin D 

      Tse, Szewah; Rolls, Hillary R; Litonjua, Augusto Ampil; Van Natta, Mark L.; Weiss, Scott Tillman; Tantisira, Kelan G. (Elsevier BV, 2012)
      Background— The adverse effects of corticosteroids on bone mineral accretion (BMA) have been well documented. Vitamin D insufficiency, a prevalent condition in the pediatric population, has also been associated with decreased ...

    • Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study 

      Perlstein, Todd Steven; Weuve, Jennifer Lynn; Schwartz, Joel David; Sparrow, David; Wright, Robert O.; Litonjua, Augusto Ampil; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007)
      Background: Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote ...

    • Diagnostic accuracy of the bronchodilator response in children 

      Tse, Szewah; Gold, Diane R.; Sordillo, Joanne; Hoffman, Elaine; Gillman, Matthew William; Rifas-Shiman, Sheryl Lynn; Fuhlbrigge, Anne Louise; Tantisira, Kelan; Weiss, Scott Tillman; Litonjua, Augusto Ampil (Elsevier BV, 2013)
      Background: The bronchodilator response (BDR) reflects the reversibility of airflow obstruction and is recommended as an adjunctive test to diagnose asthma. The validity of the commonly used definition of BDR, a 12% or ...

    • Dietary anthocyanin intake and age-related decline in lung function: longitudinal findings from the VA Normative Aging Study123 

      Mehta, Amar J; Cassidy, Aedín; Litonjua, Augusto A; Sparrow, David; Vokonas, Pantel; Schwartz, Joel (American Society for Nutrition, 2016)
      Background: It is unknown whether habitual intake of dietary flavonoids, known for their antioxidative and anti-inflammatory properties, affects longitudinal change in lung function. Objective: We investigated whether ...

    • Diversity of the Gut Microbiota and Eczema in Early Life 

      Forno, Erick; Onderdonk, Andrew Bruce; McCracken, John Patrick; Litonjua, Augusto Ampil; Laskey, Daniel; Delaney, Mary Louise Rodriguez; DuBois, Andrea M; Gold, Diane R.; Ryan, Louise Marie; Weiss, Scott Tillman; Celedón, Juan C (BioMed Central, 2008)
      Background: A modest number of prospective studies of the composition of the intestinal microbiota and eczema in early life have yielded conflicting results. Objective: To examine the relationship between the bacterial ...

    • Effects of Endotoxin Exposure on Childhood Asthma Risk are Modified by a Genetic Polymorphism in ACAA1 

      Sordillo, Joanne; Sharma, Sunita; Poon, Audrey; Su, Jessica Ann Lasky; Belanger, Kathleen; Milton, Donald Kirby; Bracken, Michael B; Triche, Elizabeth W; Leaderer, Brian P; Gold, Diane R.; Litonjua, Augusto Ampil (BioMed Central, 2011)
      Background: Polymorphisms in the endotoxin-mediated TLR4 pathway genes have been associated with asthma and atopy. We aimed to examine how genetic polymorphisms in innate immunity pathways interact with endotoxin to influence ...

    • Epigenetic Influences on Associations between Air Pollutants and Lung Function in Elderly Men: The Normative Aging Study 

      Lepeule, Johanna; Bind, Marie-Abele Catherine; Baccarelli, Andrea A.; Koutrakis, Petros; Tarantini, Letizia; Litonjua, Augusto; Sparrow, David; Vokonas, Pantel; Schwartz, Joel D. (NLM-Export, 2014)
      Background: Few studies have been performed on pulmonary effects of air pollution in the elderly—a vulnerable population with low reserve capacity—and mechanisms and susceptibility factors for potential effects are unclear. ...

    • Folate Network Genetic Variation, Plasma Homocysteine, and Global Genomic Methylation Content: A Genetic Association Study 

      Wernimont, Susan M; Stover, Patrick J; Wells, Martin T; Tucker, Katherine L; Bollati, Valentina; Cassano, Patricia A; Clark, Andrew G.; Litonjua, Augusto Ampil; Weiss, Scott Tillman; Gaziano, John Michael; Baccarelli, Andrea; Schwartz, Joel David (BioMed Central, 2011)
      Background: Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of ...

    • Folliculin Mutations Are Not Associated with Severe COPD 

      Cho, Michael Hyosang; Klanderman, Barbara Jordan; Litonjua, Augusto Ampil; Sparrow, David; Silverman, Edwin Kepner; Raby, Benjamin Alexander (BioMed Central, 2008)
      Background: Rare loss-of-function folliculin (FLCN) mutations are the genetic cause of Birt-Hogg-Dubé syndrome, a monogenic disorder characterized by spontaneous pneumothorax, fibrofolliculomas, and kidney tumors. ...

    • Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells 

      Zhou, Xiaobo; Qiu, Weiliang; Sathirapongsasuti, J. Fah; Cho, Michael Hyosang; Mancini, John D.; Lao, Taotao; Thibault, Derek M.; Litonjua, Augusto Ampil; Bakke, Per S.; Gulsvik, Amund; Lomas, David A.; Beaty, Terri H.; Hersh, Craig Palmer; Anderson, Christopher David; Geigenmuller, Ute; Raby, Benjamin Alexander; Rennard, Stephen I.; Perrella, Mark A.; Choi, Augustine M.K.; Quackenbush, John; Silverman, Edwin Kepner (Elsevier BV, 2013)
      Hedgehog Interacting Protein (HHIP) was implicated in chronic obstructive pulmonary disease (COPD) by genome-wide association studies (GWAS). However, it remains unclear how HHIP contributes to COPD pathogenesis. To identify ...

    • Genetic and histologic evidence for autophagy in asthma pathogenesis 

      Poon, Audrey H.; Chouiali, Fazila; Tse, Sze Man; Litonjua, Augusto Ampil; Hussain, Sabah N.A.; Baglole, Carolyn J.; Eidelman, David H.; Olivenstein, Ronald; Martin, James G.; Weiss, Scott Tillman; Hamid, Qutayba; Laprise, Catherine (Elsevier BV, 2012)

    • Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene 

      Himes, Blanca Elena; Jiang, Xiaofeng; Hu, Ruoxi; Wu, Ann Chen; Su, Jessica Ann Lasky; Klanderman, Barbara J.; Ziniti, John; Senter-Sylvia, Jody; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Meyers, Deborah A.; Bleecker, Eugene R.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Hanrahan, John P.; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Panettieri, Reynold A.; Markezich, Amy; Israel, Elliot; Carey, Vincent James; Tantisira, Kelan; Litonjua, Augusto Ampil; Lu, Quan; Weiss, Scott Tillman (Public Library of Science, 2012)
      Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV1) before and after the administration of a short-acting β2-agonist, the ...

    • Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma 

      Dahlin, Amber; Litonjua, Augusto; Lima, John J.; Tamari, Mayumi; Kubo, Michiaki; Irvin, Charles G.; Peters, Stephen P.; Tantisira, Kelan G. (Public Library of Science, 2015)
      Background: Genome-wide association study (GWAS) is a powerful tool to identify novel pharmacogenetic single nucleotide polymorphisms (SNPs). Leukotriene receptor antagonists (LTRAs) are a major class of asthma medications, ...

    • Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population 

      Hirota, Tomomitsu; Takahashi, Atsushi; Kubo, Michiaki; Tsunoda, Tatsuhiko; Tomita, Kaori; Doi, Satoru; Fujita, Kimie; Miyatake, Akihiko; Enomoto, Tadao; Miyagawa, Takehiko; Adachi, Mitsuru; Tanaka, Hiroshi; Niimi, Akio; Matsumoto, Hisako; Ito, Isao; Masuko, Hironori; Sakamoto, Tohru; Hizawa, Nobuyuki; Taniguchi, Masami; Lima, John J; Irvin, Charles G; Peters, Stephen P; Himes, Blanca; Litonjua, Augusto Ampil; Tantisira, Kelan; Weiss, Scott Tillman; Kamatani, Naoyuki; Nakamura, Yusuke; Tamari, Mayumi (Nature Publishing Group, 2011)