Browsing by Author "Baccarelli, Andrea"

Now showing items 1-20 of 65

    • Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study 

      Baccarelli, Andrea A; Zheng, Yinan; Zhang, Xiao; Chang, Dou; Liu, Lei; Wolf, Katherine Rose; Zhang, Zhou; McCracken, John P; Díaz, Anaité; Bertazzi, Pier Alberto; Schwartz, Joel; Wang, Sheng; Kang, Choong-Min; Koutrakis, Petros; Hou, Lifang (BioMed Central, 2014)
      Background: Exposure to ambient particulate matter (PM) has been associated with reduced lung function. Elemental components of PM have been suggested to have critical roles in PM toxicity, but their contribution to ...

    • Air Pollution, Smoking, and Plasma Homocysteine 

      Baccarelli, Andrea; Zanobetti, Antonella; Martinelli, Ida; Grillo, Paolo; Hou, Lifang; Lanzani, Guido; Mannucci, Pier Mannuccio; Bertazzi, Pier Alberto; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2006)
      Background: Mild hyperhomocysteinemia is independently associated with an increased risk of cardiovascular disease. Air pollution exposure induces short-term inflammatory changes that may determine hyperhomocysteinemia, ...

    • Airborne Particulate Matter and Mitochondrial Damage: A Cross-Sectional Study 

      Hou, Lifang; Zhu, Zhong-Zheng; Nordio, Francesco; Bonzini, Matteo; Hoxha, Mirjam; Dioni, Laura; Marinelli, Barbara; Pegoraro, Valeria; Apostoli, Pietro; Bertazzi, Pier Alberto; Zhang, Xiao; Schwartz, Joel David; Baccarelli, Andrea (BioMed Central, 2010)
      Background: Oxidative stress generation is a primary mechanism mediating the effects of Particulate Matter (PM) on human health. Although mitochondria are both the major intracellular source and target of oxidative stress, ...

    • Alu and LINE-1 methylation and lung function in the normative ageing study 

      Lange, Nancy E; Sordillo, Joanne; Tarantini, Letizia; Bollati, Valentina; Sparrow, David; Vokonas, Pantel; Zanobetti, Antonella; Schwartz, Joel David; Baccarelli, Andrea; Litonjua, Augusto Ampil; Demeo, Dawn Lisa (BMJ Publishing Group, 2012)
      Objectives: To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. Design: Cohort study. Setting: Outpatient Veterans Administration ...

    • Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals 

      Rodosthenous, Rodosthenis S.; Coull, Brent A.; Lu, Quan; Vokonas, Pantel S.; Schwartz, Joel D.; Baccarelli, Andrea A. (BioMed Central, 2016)
      Background: Air pollution from particulate matter (PM) has been linked to cardiovascular morbidity and mortality; however the underlying biological mechanisms remain to be uncovered. Gene regulation by microRNAs (miRNAs) ...

    • Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study 

      Hoxha, Mirjam; Dioni, Laura; McCracken, John Patrick; Baccarelli, Andrea; Melly, Steven John; Coull, Brent Andrew; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)
      Background: Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. Objective: ...

    • Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers 

      Hoxha, Mirjam; Dioni, Laura; Bonzini, Matteo; Pesatori, Angela Cecilia; Fustinoni, Silvia; Cavallo, Domenico; Carugno, Michele; Albetti, Benedetta; Marinelli, Barbara; Bertazzi, Pier Alberto; Schwartz, Joel David; Baccarelli, Andrea (BioMed Central, 2009)
      Background: Telomere shortening in blood leukocytes has been associated with increased morbidity and death from cardiovascular disease and cancer, but determinants of shortened telomeres, a molecular feature of biological ...

    • Associations of Toenail Arsenic, Cadmium, Mercury, Manganese, and Lead with Blood Pressure in the Normative Aging Study 

      Mordukhovich, Irina; Wright, Robert O.; Hu, Howard; Amarasiriwardena, Chitra J.; Baccarelli, Andrea; Litonjua, Augusto Ampil; Sparrow, David; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2012)
      Background: Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. ...

    • Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons 

      Bollati, Valentina; Tarantini, Letizia; Hu, Howard; Schwartz, Joel David; Wright, Rosalind Jo; Park, Sung Kyun; Sparrow, David; Vokonas, Pantel S; Baccarelli, Andrea; Wright, Robert O. (National Institute of Environmental Health Sciences, 2010)
      Background: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ...

    • Black Carbon Exposures, Blood Pressure, and Interactions with Single Nucleotide Polymorphisms in MicroRNA Processing Genes 

      Wilker, Elissa Hope; Baccarelli, Andrea; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Wright, Robert O.; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)
      Background: Black carbon (BC) is a marker of traffic pollution that has been associated with blood pressure (BP), but findings have been inconsistent. MicroRNAs (miRNAs) are emerging as key regulators of gene expression, ...

    • Blood Epigenetic Age may Predict Cancer Incidence and Mortality 

      Zheng, Yinan; Joyce, Brian T.; Colicino, Elena; Liu, Lei; Zhang, Wei; Dai, Qi; Shrubsole, Martha J.; Kibbe, Warren A.; Gao, Tao; Zhang, Zhou; Jafari, Nadereh; Vokonas, Pantel; Schwartz, Joel; Baccarelli, Andrea A.; Hou, Lifang (Elsevier, 2016)
      Biological measures of aging are important for understanding the health of an aging population, with epigenetics particularly promising. Previous studies found that tumor tissue is epigenetically older than its donors are ...

    • Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women's Health Study 

      Gao, Y; Baccarelli, Andrea; Shu, X O; Ji, B-T; Yu, K; Tarantini, L; Yang, G; Li, H-L; Hou, L; Rothman, N; Zheng, W; Gao, Y-T; Chow, W-H (Nature Publishing Group, 2012)
      Background: Recent data suggest a link between blood leukocyte DNA methylation, and cancer risk. However, reports on DNA methylation from a prospective study are unavailable for gastric cancer. Methods: We explored the ...

    • Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort 

      Hou, Lifang; Joyce, Brian Thomas; Gao, Tao; Liu, Lei; Zheng, Yinan; Penedo, Frank J.; Liu, Siran; Zhang, Wei; Bergan, Raymond; Dai, Qi; Vokonas, Pantel; Hoxha, Mirjam; Schwartz, Joel; Baccarelli, Andrea (Elsevier, 2015)
      Background: Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We ...

    • Cardiac Autonomic Dysfunction: Particulate Air Pollution Effects Are Modulated by Epigenetic Immunoregulation of Toll‐like Receptor 2 and Dietary Flavonoid Intake 

      Zhong, Jia; Colicino, Elena; Lin, Xinyi; Mehta, Amar; Kloog, Itai; Zanobetti, Antonella; Byun, Hyang‐Min; Bind, Marie‐Abèle; Cantone, Laura; Prada, Diddier; Tarantini, Letizia; Trevisi, Letizia; Sparrow, David; Vokonas, Pantel; Schwartz, Joel; Baccarelli, Andrea A. (Blackwell Publishing Ltd, 2015)
      Background: Short‐term fine particles (PM2.5) exposure is associated with reduced heart rate variability, a strong predictor of cardiac mortality among older people. Identifying modifiable factors that confer susceptibility ...

    • A Case-Control Study of Peripheral Blood Mitochondrial DNA Copy Number and Risk of Renal Cell Carcinoma 

      Purdue, Mark P.; Hofmann, Jonathan N.; Colt, Joanne S.; Hoxha, Mirjam; Ruterbusch, Julie J.; Davis, Faith G.; Rothman, Nathaniel; Wacholder, Sholom; Schwartz, Kendra L.; Baccarelli, Andrea; Chow, Wong-Ho (Public Library of Science, 2012)
      Background: Low mitochondrial DNA (mtDNA) copy number is a common feature of renal cell carcinoma (RCC), and may influence tumor development. Results: from a recent case-control study suggest that low mtDNA copy number in ...

    • Changes in DNA Methylation in Mouse Lungs after a Single Intra-Tracheal Administration of Nanomaterials 

      Tabish, Ali M.; Poels, Katrien; Byun, Hyang-Min; luyts, Katrien; Baccarelli, Andrea A.; Martens, Johan; Kerkhofs, Stef; Seys, Sven; Hoet, Peter; Godderis, Lode (Public Library of Science, 2017)
      Aims This study aimed to investigate the effects of nanomaterial (NM) exposure on DNA methylation. Methods and Results: Intra-tracheal administration of NM: gold nanoparticles (AuNPs) of 5-, 60- and 250-nm diameter; ...

    • Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature 

      Liu, Cong; Xu, Junhui; Chen, Yahong; Guo, Xinbiao; Zheng, Yinan; Wang, Qianfei; Chen, Yiyong; Ni, Yang; Zhu, Yidan; Joyce, Brian Thomas; Baccarelli, Andrea; Deng, Furong; Zhang, Wei; Hou, Lifang (BioMed Central, 2015)
      Background: Current studies of environmental health suggest a link between air pollution components, such as particulate matter (PM), and various diseases. However, the specific genes and regulatory mechanisms implicated ...

    • CIS Sequence Effects on Gene Expression 

      Bergen, Andrew W; McDaniel, Timothy K; Kuhn, Kenneth; Pfeiffer, Ruth; Kakol, Jerry; Bender, Patrick; Jacobs, Kevin; Packer, Bernice; Chanock, Stephen J; Yeager, Meredith; Baccarelli, Andrea (BioMed Central, 2007)
      Background: Sequence and transcriptional variability within and between individuals are typically studied independently. The joint analysis of sequence and gene expression variation (genetical genomics) provides insight ...

    • Comparison of multiplexed reduced representation bisulfite sequencing (mRRBS) with the 450K Illumina Human BeadChip: from concordance to practical applications for methylomic profiling in epigenetic epidemiologic studies 

      Carmona, Juan Jose; Izzi, Benedetta; Just, Allan Carpenter; Barupal, Jitendra; Binder, Alexandra Margaret Lynn; Hutchinson, John N; Hofmann, Oliver Marc; Schwartz, Joel David; Baccarelli, Andrea; Michels, Karin B. (BioMed Central, 2013)

    • Countervailing effects of income, air pollution, smoking, and obesity on aging and life expectancy: population-based study of U.S. Counties 

      Allen, Ryan T.; Hales, Nicholas M.; Baccarelli, Andrea; Jerrett, Michael; Ezzati, Majid; Dockery, Douglas W.; Pope, C. Arden (BioMed Central, 2016)
      Background: Income, air pollution, obesity, and smoking are primary factors associated with human health and longevity in population-based studies. These four factors may have countervailing impacts on longevity. This ...