Browsing by Author "Smeaton, Laura"
Now showing items 1-8 of 8
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Detection of Microbial Translocation in HIV and SIV Infection Using the Limulus Amebocyte Lysate Assay is Masked by Serum and Plasma
Balagopal, Ashwin; Gama, Lucio; Franco, Veronica; Russell, Julia N.; Quinn, Jeffrey; Higgins, Yvonne; Smeaton, Laura Marie; Clements, Janice E.; Thomas, David L.; Gupta, Amita (Public Library of Science, 2012)Objective: Microbial translocation (MT) is thought to be a major contributor to the pathogenesis of HIV-related immune activation, and circulating lipopolysaccharide (LPS) from Gram-negative bacteria is the principle ... -
Efficacy and Safety of Three Antiretroviral Regimens for Initial Treatment of HIV-1: A Randomized Clinical Trial in Diverse Multinational Settings
Campbell, Thomas B.; Smeaton, Laura Marie; Kumarasamy, N.; Flanigan, Timothy; Klingman, Karin L.; Firnhaber, Cynthia; Grinsztejn, Beatriz; Hosseinipour, Mina C.; Kumwenda, Johnstone; Lalloo, Umesh; Riviere, Cynthia; Sanchez, Jorge; Melo, Marineide; Supparatpinyo, Khuanchai; Tripathy, Srikanth; Martinez, Ana I.; Nair, Apsara; Walawander, Ann; Moran, Laura; Chen, Yun; Snowden, Wendy; Rooney, James F.; Uy, Jonathan; Schooley, Robert T.; De Gruttola, Victor Gerard; Hakim, James Gita (Public Library of Science, 2012)Background: Antiretroviral regimens with simplified dosing and better safety are needed to maximize the efficiency of antiretroviral delivery in resource-limited settings. We investigated the efficacy and safety of ... -
Immune Activation Markers in Peripartum Women in Botswana: Association with Feeding Strategy and Maternal Morbidity
Russell, Elizabeth S.; Mohammed, Terence; Smeaton, Laura Marie; Jorowe, Baitshepi; MacLeod, Iain James; Hoffman, Risa M.; Currier, Judith S.; Moyo, Sikhulile; Essex, Max; Lockman, Shahin (Public Library of Science (PLoS), 2014)Hormone levels shift the immune state in HIV-uninfected pregnant and breastfeeding women away from Th1 responses and toward regulation to permit fetal tolerance. Limited data exist on inflammation during pregnancy or ... -
Outcomes among HIV-1 Infected Individuals First Starting Antiretroviral Therapy with Concurrent Active TB or Other AIDS-Defining Disease
Périssé, André R. S.; Smeaton, Laura; Chen, Yun; La Rosa, Alberto; Walawander, Ann; Nair, Apsara; Grinsztejn, Beatriz; Santos, Breno; Kanyama, Cecilia; Hakim, James; Nyirenda, Mulinda; Kumarasamy, Nagalingeswaran; Lalloo, Umesh G.; Flanigan, Timothy; Campbell, Thomas B.; Hughes, Michael D. (Public Library of Science, 2013)Background: Tuberculosis (TB) is common among HIV-infected individuals in many resource-limited countries and has been associated with poor survival. We evaluated morbidity and mortality among individuals first starting ... -
Presence of Plasmodium falciparum DNA in Plasma Does Not Predict Clinical Malaria in an HIV-1 Infected Population
Orlov, Marika; Smeaton, Laura M.; Kumwenda, Johnstone; Hosseinipour, Mina C.; Campbell, Thomas B.; Schooley, Robert T. (Public Library of Science, 2015)Background: HIV-1 and Plasmodium falciparum malaria cause substantial morbidity in Sub-Saharan Africa, especially as co-infecting pathogens. We examined the relationship between presence of P. falciparum DNA in plasma ... -
A Randomized Comparison of Anthropomorphic Changes With Preferred and Alternative Efavirenz-Based Antiretroviral Regimens in Diverse Multinational Settings
Erlandson, Kristine M.; Taejaroenkul, Sineenart; Smeaton, Laura; Gupta, Amita; Singini, Isaac L.; Lama, Javier R.; Mngqibisa, Rosie; Firnhaber, Cynthia; Cardoso, Sandra Wagner; Kanyama, Cecilia; Machado da Silva, Andre L.; Hakim, James G.; Kumarasamy, Nagalingeswaran; Campbell, Thomas B.; Hughes, Michael D. (Oxford University Press, 2015)Background. Existing data on anthropomorphic changes in resource-limited settings primarily come from observational or cross-sectional studies. Data from randomized clinical trials are needed to inform treatment decisions ... -
Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine
Lockman, Shahin; Shapiro, Roger L.; Smeaton, Laura Marie; Wester, Carolyn; Thior, Ibou; Stevens, Lisa; Chand, Fatima; Makhema, Joseph Moeketsi; Moffat, Claire; Asmelash, Aida; Ndase, Patrick; van Widenfelt, Peter Arimim Eri; Mazhani, Loeto; Novitsky, Vladimir A.; Lagakos, Stephen; Essex, Myron Elmer (New England Journal of Medicine (NEJM/MMS), 2007)BACKGROUND: A single dose of nevirapine during labor reduces perinatal transmission of human immunodeficiency virus type 1 (HIV-1) but often leads to viral nevirapine resistance mutations in mothers and infants. METHODS: ... -
Vitamin D Insufficiency in HIV-infected Pregnant Women Receiving Antiretroviral Therapy is Not Associated With Morbidity, Mortality or Growth Impairment in Their Uninfected Infants in Botswana
Powis, Kathleen Marie; Lockman, Shahin; Smeaton, Laura Marie; Hughes, Michael David; Fawzi, Wafaie W.; Ogwu, Anthony; Moyo, Sikhulile; van Widenfelt, Erik; von Oettingen, Julia Elisabeth; Makhema, Joseph; Essex, Max; Shapiro, Roger L. (Ovid Technologies (Wolters Kluwer Health), 2014)Background Low maternal 25(OH)D (vitamin D) values have been associated with higher mortality and impaired growth among HIV-exposed uninfected (HEU) infants of antiretroviral (ART)-naïve women. These associations have ...