Browsing by Author "Schuetz, Christian"
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Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation
Wang, Ping; Yigit, Mehmet V; Medarova, Zdravka Ognyanova; Wei, Lingling; Dai, Guangping; Schuetz, Christian; Moore, Anna V. (American Diabetes Association, 2011)OBJECTIVE Recent advances in human islet transplantation are hampered by significant graft loss shortly after transplantation and inability to follow islet fate directly. Both issues were addressed by utilizing a dual-purpose ... -
Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
Blum, Barak; Hrvatin, Sini[sbreve]?a; Schuetz, Christian; Bonal, Claire; Rezania, Alireza; Melton, Douglas A. (Nature Publishing Group, 2012)Insulin-expressing cells that have been differentiated from human pluripotent stem cells in vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell maturation in mice was studied to find genetic ... -
Mechanisms of Xenogeneic Baboon Platelet Aggregation and Phagocytosis by Porcine Liver Sinusoidal Endothelial Cells
Peng, Qiang; Yeh, Heidi; Wei, Lingling; Enjyoj, Keiichi; Machaidze, Zurab; Csizmad, Eva; Schuetz, Christian; Lee, Kang Mi; Deng, Shaoping; Robson, Simon Christopher; Markmann, James; Buhler, Leo (Public Library of Science, 2012)Background: Baboons receiving xenogeneic livers from wild type and transgenic pigs survive less than 10 days. One of the major issues is the early development of profound thrombocytopenia that results in fatal hemorrhage. ...