Now showing items 1-15 of 15

    • The Aromatase Gene (CYP19A1) Variants and Circulating Hepatocyte Growth Factor in Postmenopausal Women 

      Lin, Jennifer H.; Gunter, Marc J.; Manson, JoAnn Elisabeth; Rexrode, Kathryn Marian; Cook, Nancy Romanowicz; Kraft, Peter; Cochrane, Barbara B.; Chlebowski, Rowan T.; Ho, Gloria Y. F.; Zhang, Shumin (Public Library of Science, 2012)
      Background: Estrogen and androgen have been linked to the regulation of circulating hepatocyte growth factor (HGF), an adipose tissue-derived cytokine. It is possible that the CYP19A1 gene which alters sex hormones production ...
    • Association Between High-Sensitivity C-Reactive Protein and Total Stroke by Hypertensive Status Among Men 

      Jiménez, Monik C; Rexrode, Kathryn M; Glynn, Robert J; Ridker, Paul M; Gaziano, J Michael; Sesso, Howard D (John Wiley & Sons, Ltd, 2015)
      Background: High-sensitivity C-reactive protein (hsCRP), a marker of systemic inflammation, may promote atherosclerosis, particularly among adults with elevated blood pressure; however, data are sparse. We examined the ...
    • Associations of Bowel Movement Frequency with Risk of Cardiovascular Disease and Mortality among US Women 

      Ma, Wenjie; Li, Yanping; Heianza, Yoriko; Staller, Kyle D.; Chan, Andrew T.; Rimm, Eric B.; Rexrode, Kathryn M.; Qi, Lu (Nature Publishing Group, 2016)
      Emerging evidence suggests a potential impact of gastrointestinal function on cardiometabolic risk. Abnormal bowel movements have been related to various cardiovascular risk factors such as dyslipidemia, hypertension, ...
    • C-Reactive Protein (CRP) Gene Polymorphisms, CRP Levels, and Risk of Incident Coronary Heart Disease in Two Nested Case-Control Studies 

      Pai, Jennifer Kai-cha; Mukamal, Ken J.; Rexrode, Kathryn Marian; Rimm, Eric B. (Public Library of Science, 2008)
      Background: C-reactive protein (CRP), an acute phase reactant and marker of inflammation, has been shown to predict risk of incident cardiovascular events. However, few studies have comprehensively examined six common ...
    • Dietary and Plasma Magnesium and Risk of Coronary Heart Disease Among Women 

      Chiuve, Stephanie Elizabeth; Sun, Qi; Curhan, Gary Craig; Taylor, Eric N.; Spiegelman, Donna Lynn; Willett, Walter C.; Manson, JoAnn Elisabeth; Rexrode, Kathryn Marian; Albert, Christine Marie (Blackwell Publishing Ltd, 2013)
      Background: Magnesium is associated with lower risk of sudden cardiac death, possibly through antiarrhythmic mechanisms. Magnesium influences endothelial function, inflammation, blood pressure, and diabetes, but a direct ...
    • Dietary fiber intake and mortality among survivors of myocardial infarction: prospective cohort study 

      Li, Shanshan; Flint, Alan; Pai, Jennifer K; Forman, John P; Hu, Frank B; Willett, Walter C; Rexrode, Kathryn M; Mukamal, Kenneth J; Rimm, Eric B (BMJ Publishing Group Ltd., 2014)
      Objective: To evaluate the associations of dietary fiber after myocardial infarction (MI) and changes in dietary fiber intake from before to after MI with all cause and cardiovascular mortality. Design: Prospective cohort ...
    • Effect Modification of Long‐Term Air Pollution Exposures and the Risk of Incident Cardiovascular Disease in US Women 

      Hart, Jaime E.; Puett, Robin C.; Rexrode, Kathryn M.; Albert, Christine M.; Laden, Francine (John Wiley and Sons Inc., 2015)
      Background: Ambient air pollution exposures have been frequently linked to cardiovascular disease (CVD) morbidity and mortality. However, less is known about the populations most susceptible to these adverse effects. Methods ...
    • A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation 

      Coviello, Andrea D.; Haring, Robin; Wellons, Melissa; Vaidya, Dhananjay; Lehtimäki, Terho; Keildson, Sarah; Lunetta, Kathryn L.; He, Chunyan; Fornage, Myriam; Lagou, Vasiliki; Mangino, Massimo; Onland-Moret, N. Charlotte; Eriksson, Joel; Garcia, Melissa; Liu, Yong Mei; Koster, Annemarie; Lohman, Kurt; Lyytikäinen, Leo-Pekka; Petersen, Ann-Kristin; Stolk, Lisette; Vandenput, Liesbeth; Wood, Andrew R.; Zhuang, Wei Vivian; Ruokonen, Aimo; Hartikainen, Anna-Liisa; Pouta, Anneli; Bandinelli, Stefania; Biffar, Reiner; Brabant, Georg; Chen, Yuhui; Cummings, Steven; Ferrucci, Luigi; Gunter, Marc J.; Martikainen, Hannu; Homuth, Georg; Illig, Thomas; Jansson, John-Olov; Karlsson, Magnus; Kettunen, Johannes; Liu, Jingmin; Ljunggren, Östen; Lorentzon, Mattias; Maggio, Marcello; Markus, Marcello R. P.; Mellström, Dan; Miljkovic, Iva; Mirel, Daniel; Morin Papunen, Laure; Peeters, Petra H. M.; Prokopenko, Inga; Raffel, Leslie; Reincke, Martin; Reiner, Alex P.; Rivadeneira, Fernando; Schwartz, Stephen M.; Siscovick, David; Soranzo, Nicole; Stöckl, Doris; Uitterlinden, André G.; van Gils, Carla H.; Vasan, Ramachandran S.; Wichmann, H.-Erich; Zhai, Guangju; Bhasin, Shalender; Bidlingmaier, Martin; Chanock, Stephen J.; Harris, Tamara B.; Kähönen, Mika; Liu, Simin; Ouyang, Pamela; Spector, Tim D.; van der Schouw, Yvonne T.; Viikari, Jorma; Wallaschofski, Henri; McCarthy, Mark I.; Frayling, Timothy M.; Murray, Anna; Franks, Steve; Järvelin, Marjo-Riitta; de Jong, Frank H.; Raitakari, Olli; Teumer, Alexander; Ohlsson, Claes; Murabito, Joanne M.; Perry, John R. B.; Chen, Brian; Prescott, Jennifer; Cox, David G.; Hankinson, Susan Elizabeth; Hofman, Albert; Johnson, Andrew D.; Karasik, David; Kiel, Douglas P.; Nelson, Sarah; Rexrode, Kathryn Marian; Tworoger, Shelley Slate; De Vivo, Immaculata; Hunter, David J.; Kraft, Peter (Public Library of Science, 2012)
      Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases ...
    • Healthy Lifestyle and Leukocyte Telomere Length in U.S. Women 

      Sun, Qi; Shi, Ling; Prescott, Jennifer; Chiuve, Stephanie Elizabeth; Hu, Frank B.; De Vivo, Immaculata; Stampfer, Meir; Franks, Paul W.; Manson, JoAnn Elisabeth; Rexrode, Kathryn Marian (Public Library of Science, 2012)
      Context: Whether a healthy lifestyle may be associated with longer telomere length is largely unknown. Objectives: To examine healthy lifestyle practices, which are primary prevention measures against major age-related ...
    • Hemoglobin A1c Is Associated With Increased Risk of Incident Coronary Heart Disease Among Apparently Healthy, Nondiabetic Men and Women 

      Pai, Jennifer; Cahill, Leah; Hu, Frank B.; Rexrode, Kathryn Marian; Manson, JoAnn Elisabeth; Rimm, Eric B. (Blackwell Publishing Ltd, 2013)
      Background: Hemoglobin A1c (HbA1c), a time‐integrated marker of glycemic control, predicts risk of coronary heart disease (CHD) among diabetics. Few studies have examined HbA1c and risk of CHD among women and men without ...
    • High Phobic Anxiety Is Related to Lower Leukocyte Telomere Length in Women 

      Okereke, Olivia Ifeoma; Prescott, Jennifer; Wong, Jason Yat Yang; Han, Jiali; Rexrode, Kathryn Marian; De Vivo, Immaculata (Public Library of Science, 2012)
      Background: Chronic psychological distress has been linked to shorter telomeres, an indication of accelerated aging. Yet, little is known about relations of anxiety to telomeres. We examined whether a typically chronic ...
    • Lifestyle‐Based Prediction Model for the Prevention of CVD: The Healthy Heart Score 

      Chiuve, Stephanie E.; Cook, Nancy R.; Shay, Christina M.; Rexrode, Kathryn M.; Albert, Christine M.; Manson, JoAnn E.; Willett, Walter C.; Rimm, Eric B. (Blackwell Publishing Ltd, 2014)
      Background: Clinical practice focuses on the primary prevention of cardiovascular (CV) disease (CVD) through the modification and pharmacological treatment of elevated risk factors. Prediction models based on established ...
    • Low Carbohydrate Diet From Plant or Animal Sources and Mortality Among Myocardial Infarction Survivors 

      Li, Shanshan; Flint, Alan; Pai, Jennifer K.; Forman, John P.; Hu, Frank B.; Willett, Walter C.; Rexrode, Kathryn M.; Mukamal, Kenneth J.; Rimm, Eric B. (Blackwell Publishing Ltd, 2014)
      Background: The healthiest dietary pattern for myocardial infarction (MI) survivors is not known. Specific long‐term benefits of a low‐carbohydrate diet (LCD) are unknown, whether from animal or vegetable sources. There ...
    • Mediterranean diet and telomere length in Nurses’ Health Study: population based cohort study 

      Crous-Bou, Marta; Fung, Teresa T; Prescott, Jennifer; Julin, Bettina; Du, Mengmeng; Sun, Qi; Rexrode, Kathryn M; Hu, Frank B; De Vivo, Immaculata (BMJ Publishing Group Ltd., 2014)
      Objective: To examine whether adherence to the Mediterranean diet was associated with longer telomere length, a biomarker of aging. Design: Population based cohort study. Setting: Nurses’ Health Study, an ongoing prospective ...
    • Plasma Levels of Fetuin‐A and Risk of Coronary Heart Disease in US Women: The Nurses' Health Study 

      Sun, Qi; Jiménez, Monik C.; Townsend, Mary K.; Rimm, Eric B.; Manson, JoAnn E.; Albert, Christine M.; Rexrode, Kathryn M. (Blackwell Publishing Ltd, 2014)
      Background: Fetuin‐A may be involved in the etiology of coronary heart disease (CHD) through opposing pathways (ie, promoting insulin resistance and inhibiting ectopic calcification). We aimed to explicitly examine whether ...