Now showing items 1-6 of 6

    • Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression 

      Pearson-Fuhrhop, Kristin M.; Dunn, Erin C.; Mortero, Sarah; Devan, William J.; Falcone, Guido J.; Lee, Phil; Holmes, Avram J.; Hollinshead, Marisa O.; Roffman, Joshua L.; Smoller, Jordan W.; Rosand, Jonathan; Cramer, Steven C. (Public Library of Science, 2014)
      Background: Depression is a common source of human disability for which etiologic insights remain limited. Although abnormalities of monoamine neurotransmission, including dopamine, are theorized to contribute to the ...
    • Genetic variants in CETP increase risk of intracerebral hemorrhage 

      Anderson, Christopher D.; Falcone, Guido J.; Phuah, Chia‐Ling; Radmanesh, Farid; Brouwers, H. Bart; Battey, Thomas W. K.; Biffi, Alessandro; Peloso, Gina M.; Liu, Dajiang J.; Ayres, Alison M.; Goldstein, Joshua N.; Viswanathan, Anand; Greenberg, Steven M.; Selim, Magdy; Meschia, James F.; Brown, Devin L.; Worrall, Bradford B.; Silliman, Scott L.; Tirschwell, David L.; Flaherty, Matthew L.; Kraft, Peter; Jagiella, Jeremiasz M.; Schmidt, Helena; Hansen, Björn M.; Jimenez‐Conde, Jordi; Giralt‐Steinhauer, Eva; Elosua, Roberto; Cuadrado‐Godia, Elisa; Soriano, Carolina; van Nieuwenhuizen, Koen M.; Klijn, Catharina J. M.; Rannikmae, Kristiina; Samarasekera, Neshika; Salman, Rustam Al‐Shahi; Sudlow, Catherine L.; Deary, Ian J.; Morotti, Andrea; Pezzini, Alessandro; Pera, Joanna; Urbanik, Andrzej; Pichler, Alexander; Enzinger, Christian; Norrving, Bo; Montaner, Joan; Fernandez‐Cadenas, Israel; Delgado, Pilar; Roquer, Jaume; Lindgren, Arne; Slowik, Agnieszka; Schmidt, Reinhold; Kidwell, Chelsea S.; Kittner, Steven J.; Waddy, Salina P.; Langefeld, Carl D.; Abecasis, Goncalo; Willer, Cristen J.; Kathiresan, Sekar; Woo, Daniel; Rosand, Jonathan (John Wiley and Sons Inc., 2016)
      Objective: In observational epidemiologic studies, higher plasma high‐density lipoprotein cholesterol (HDL‐C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease ...
    • Modeling Intracerebral Hemorrhage Growth and Response to Anticoagulation 

      Greenberg, Charles H.; Frosch, Matthew P.; Goldstein, Joshua Norkin; Rosand, Jonathan; Greenberg, Steven Mark (Public Library of Science, 2012)
      The mechanism for hemorrhage enlargement in the brain, a key determinant of patient outcome following hemorrhagic stroke, is unknown. We performed computer-based stochastic simulation of one proposed mechanism, in which ...
    • A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach 

      Traylor, Matthew; Mäkelä, Kari-Matti; Kilarski, Laura L.; Holliday, Elizabeth G.; Devan, William J.; Nalls, Mike A.; Wiggins, Kerri L.; Zhao, Wei; Cheng, Yu-Ching; Achterberg, Sefanja; Malik, Rainer; Sudlow, Cathie; Bevan, Steve; Raitoharju, Emma; Oksala, Niku; Thijs, Vincent; Lemmens, Robin; Lindgren, Arne; Slowik, Agnieszka; Maguire, Jane M.; Walters, Matthew; Algra, Ale; Sharma, Pankaj; Attia, John R.; Boncoraglio, Giorgio B.; Rothwell, Peter M.; de Bakker, Paul I. W.; Bis, Joshua C.; Saleheen, Danish; Kittner, Steven J.; Mitchell, Braxton D.; Rosand, Jonathan; Meschia, James F.; Levi, Christopher; Dichgans, Martin; Lehtimäki, Terho; Lewis, Cathryn M.; Markus, Hugh S. (Public Library of Science, 2014)
      Genome-wide association studies (GWAS) have begun to identify the common genetic component to ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction ...
    • Screening for Familial APP Mutations in Sporadic Cerebral Amyloid Angiopathy 

      Biffi, Alessandro; Plourde, Anna; Shen, Yiping; Onofrio, Robert; Smith, Eric E.; Frosch, Matthew P.; Prada, Claudia M.; Gusella, James Francis; Greenberg, Steven Mark; Rosand, Jonathan (Public Library of Science, 2010)
      Background: Advances in genetic technology have revealed that variation in the same gene can cause both rare familial and common sporadic forms of the same disease. Cerebral amyloid angiopathy (CAA), a common cause of ...
    • Selective Disruption of the Cerebral Neocortex in Alzheimer's Disease 

      Desikan, Rahul S.; Schmansky, Nicholas J.; Cabral, Howard J.; Hess, Christopher P.; Weiner, Michael W.; Kemper, Thomas L.; Dale, Anders M.; Sabuncu, Mert R; the Alzheimer’s Disease Neuroimaging Initiative; Reuter, Martin; Biffi, Alessandro; Anderson, Christopher David; Rosand, Jonathan; Salat, David H.; Sperling, Reisa Anne; Fischl, Bruce R. (Public Library of Science, 2010)
      Background: Alzheimer's disease (AD) and its transitional state mild cognitive impairment (MCI) are characterized by amyloid plaque and tau neurofibrillary tangle (NFT) deposition within the cerebral neocortex and neuronal ...