Now showing items 1-3 of 3

    • Increased Tumorigenesis Associated with Loss of the Tumor Suppressor Gene Cadm1 

      van der Weyden, Louise; Arends, Mark J; Rust, Alistair G; Poulogiannis, George; McIntyre, Rebecca E; Adams, David J (BioMed Central, 2012)
      Background: CADM1 encodes an immunoglobulin superfamily (IGSF) cell adhesion molecule. Inactivation of CADM1, either by promoter hypermethylation or loss of heterozygosity, has been reported in a wide variety of tumor ...
    • IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer 

      Day, Elizabeth; Poulogiannis, George; McCaughan, Frank; Mulholland, Shani; Arends, Mark J; Ibrahim, Ashraf E K; Dear, Paul H (Blackwell Publishing Ltd, 2013)
      Copy number alterations are frequently found in colorectal cancer (CRC), and recurrent gains or losses are likely to correspond to regions harbouring genes that promote or impede carcinogenesis respectively. Gain of ...
    • Nuclear Receptor Binding Protein 1 Regulates Intestinal Progenitor Cell Homeostasis and Tumour Formation 

      Wilson, Catherine H; Crombie, Catriona; van der Weyden, Louise; Rust, Alistair G; Pardo, Mercedes; Gracia, Tannia; Yu, Lu; Choudhary, Jyoti; Poulin, Gino B; McIntyre, Rebecca E; Winton, Douglas J; March, H Nikki; Arends, Mark J; Fraser, Andrew G; Poulogiannis, George; Adams, David J. (Nature Publishing Group, 2012)
      Genetic screens in simple model organisms have identified many of the key components of the conserved signal transduction pathways that are oncogenic when misregulated. Here, we identify H37N21.1 as a gene that regulates ...