Now showing items 1-5 of 5

    • Effects of Endotoxin Exposure on Childhood Asthma Risk are Modified by a Genetic Polymorphism in ACAA1 

      Sordillo, Joanne; Sharma, Sunita; Poon, Audrey; Su, Jessica Ann Lasky; Belanger, Kathleen; Milton, Donald Kirby; Bracken, Michael B; Triche, Elizabeth W; Leaderer, Brian P; Gold, Diane R.; Litonjua, Augusto Ampil (BioMed Central, 2011)
      Background: Polymorphisms in the endotoxin-mediated TLR4 pathway genes have been associated with asthma and atopy. We aimed to examine how genetic polymorphisms in innate immunity pathways interact with endotoxin to influence ...
    • Expression analysis of asthma candidate genes during human and murine lung development 

      Melén, Erik; Kho, Alvin Thong-Juak; Sharma, Sunita; Gaedigk, Roger; Leeder, J Steven; Mariani, Thomas J; Carey, Vincent James; Weiss, Scott Tillman; Tantisira, Kelan (Springer Science + Business Media, 2011)
      Background: Little is known about the role of most asthma susceptibility genes during human lung development. Genetic determinants for normal lung development are not only important early in life, but also for later lung ...
    • A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes 

      Sharma, Sunita; Zhou, Xiaobo; Thibault, Derek M.; Himes, Blanca; Liu, Andy; Szefler, Stanley J.; Strunk, Robert; Castro, Mario; Hansel, Nadia N.; Diette, Gregory B.; Vonakis, Becky M.; Adkinson, N. Franklin; Avila, Lydiana; Soto-Quiros, Manuel; Barraza-Villareal, Albino; Lemanske, Robert F.; Solway, Julian; Krishnan, Jerry; White, Steven James; Cheadle, Chris; Berger, Alan E.; Fan, Jinshui; Boorgula, Meher Preethi; Nicolae, Dan; Gilliland, Frank; Barnes, Kathleen; London, Stephanie J.; Martinez, Fernando; Ober, Carole; Celedón, Juan C.; Carey, Vincent James; Weiss, Scott Tillman; Raby, Benjamin Alexander (Elsevier BV, 2014)
      Background: Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes ...
    • The genomic origins of asthma 

      Sharma, Sunita; Chhabra, Divya; Kho, Alvin Thong-Juak; Hayden, Lystra P.; Tantisira, Kelan; Weiss, Scott Tillman (BMJ, 2014)
      Lung function tracks from the earliest age that it can be reliably measured. Genome wide association studies (GWAS) suggest that most variants identified for common complex traits are both regulatory in function and active ...
    • Vitamin D related genes in lung development and asthma pathogenesis 

      Kho, Alvin T; Sharma, Sunita; Qiu, Weiliang; Gaedigk, Roger; Klanderman, Barbara; Niu, Simin; Anderson, Chris; Leeder, James S; Weiss, Scott T; Tantisira, Kelan G (BioMed Central, 2013)
      Background: Poor maternal vitamin D intake is a risk factor for subsequent childhood asthma, suggesting that in utero changes related to vitamin D responsive genes might play a crucial role in later disease susceptibility. ...