Now showing items 1-2 of 2

    • Cancer aneuploidies are shaped primarily by effects on tumour fitness 

      Shih, Juliann; Sarmashghi, Shahab; Zhakula-Kostadinova, Nadja; Georgis, Yohanna; Hoyt, Stephanie H.; Cuoco, Michael S.; Gao, Galen F.; Spurr, Liam F.; Berger, Ashton C.; Ha, Gavin; Rendo, Veronica; Shen, Hui; Meyerson, Matthew; Cherniack, Andrew D.; Taylor, Alison M.; Beroukhim, Rameen (Springer Science and Business Media LLC, 2023-06-28)
      Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent alteration in cancer genomes1,2. However, it is still debated whether their prevalence is due to selection or because they are readily generated ...
    • The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis 

      Ben-David, Uri; Ha, Gavin; Khadka, Prasidda; Jin, Xin; Wong, Bang; Franke, Lude; Golub, Todd R. (Nature Publishing Group, 2016)
      Aneuploidy and copy-number alterations (CNAs) are a hallmark of human cancer. Although genetically engineered mouse models (GEMMs) are commonly used to model human cancer, their chromosomal landscapes remain underexplored. ...