Browsing by Author "Atri, Alireza"
Now showing items 1-9 of 9
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Cognitively Stimulating Activities: Effects on Cognition across Four Studies with up to 21 Years of Longitudinal Data
Mitchell, Meghan B.; Cimino, Cynthia R.; Benitez, Andreana; Brown, Cassandra L.; Gibbons, Laura E.; Kennison, Robert F.; Shirk, Steven D.; Atri, Alireza; Robitaille, Annie; MacDonald, Stuart W. S.; Lindwall, Magnus; Zelinski, Elizabeth M.; Willis, Sherry L.; Schaie, K. Warner; Johansson, Boo; Dixon, Roger A.; Mungas, Dan M.; Hofer, Scott M.; Piccinin, Andrea M. (Hindawi Publishing Corporation, 2012)Engagement in cognitively stimulating activities has been considered to maintain or strengthen cognitive skills, thereby minimizing age-related cognitive decline. While the idea that there may be a modifiable behavior that ... -
The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals
Dickerson, Bradford Clark; Bakkour, Akram; Salat, David H.; Feczko, Eric; Pacheco, Jenni; Greve, Douglas N.; Grodstein, Francine; Wright, Christopher Ian; Blacker, Deborah Lynne; Rosas, Herminia Diana; Sperling, Reisa Anne; Atri, Alireza; Growdon, John Herbert; Hyman, Bradley Theodore; Morris, John C.; Fischl, Bruce R.; Buckner, Randy Lee (Oxford University Press, 2009)Alzheimer's disease (AD) is associated with neurodegeneration in vulnerable limbic and heteromodal regions of the cerebral cortex, detectable in vivo using magnetic resonance imaging. It is not clear whether abnormalities ... -
Cumulative, additive benefits of memantine-donepezil combination over component monotherapies in moderate to severe Alzheimer’s dementia: a pooled area under the curve analysis
Atri, Alireza; Hendrix, Suzanne B; Pejović, Vojislav; Hofbauer, Robert K; Edwards, John; Molinuevo, José Luis; Graham, Stephen M (BioMed Central, 2015)Introduction: Treatment in moderate or severe Alzheimer’s disease (AD) often involves adding memantine to a cholinesterase-inhibitor (ChEI: donepezil, galantamine, rivastigmine). Evidence from six-month randomized trials ... -
Dynamic Associations of Change in Physical Activity and Change in Cognitive Function: Coordinated Analyses of Four Longitudinal Studies
Lindwall, Magnus; Cimino, Cynthia R.; Gibbons, Laura E.; Mitchell, Meghan B.; Benitez, Andreana; Brown, Cassandra L.; Kennison, Robert F.; Shirk, Steven D.; Atri, Alireza; Robitaille, Annie; MacDonald, Stuart W. S.; Zelinski, Elizabeth M.; Willis, Sherry L.; Schaie, K. Warner; Johansson, Boo; Praetorius, Marcus; Dixon, Roger A.; Mungas, Dan M.; Hofer, Scott M.; Piccinin, Andrea M. (Hindawi Publishing Corporation, 2012)The present study used a coordinated analyses approach to examine the association of physical activity and cognitive change in four longitudinal studies. A series of multilevel growth models with physical activity included ... -
In the Information Age, do dementia caregivers get the information they need? Semi-structured interviews to determine informal caregivers’ education needs, barriers, and preferences
Peterson, Kendra; Hahn, Howard; Lee, Amber J.; Madison, Catherine A.; Atri, Alireza (BioMed Central, 2016)Background: Most patients with dementia or cognitive impairment receive care from family members, often untrained for this challenging role. Caregivers may not access publicly available caregiving information, and caregiver ... -
Memantine in patients with Alzheimer's disease receiving donepezil: new analyses of efficacy and safety for combination therapy
Atri, Alireza; Molinuevo, José L; Lemming, Ole; Wirth, Yvonne; Pulte, Irena; Wilkinson, David (BioMed Central, 2013)Introduction: Memantine and cholinesterase inhibitors potentially offer additional benefits in Alzheimer's disease (AD) when used together. This study assessed the efficacy and safety of combination treatment with memantine ... -
Social Activity and Cognitive Functioning Over Time: A Coordinated Analysis of Four Longitudinal Studies
Brown, Cassandra L.; Gibbons, Laura E.; Kennison, Robert F.; Robitaille, Annie; Lindwall, Magnus; Mitchell, Meghan B.; Shirk, Steven D.; Atri, Alireza; Cimino, Cynthia R.; Benitez, Andreana; MacDonald, Stuart W. S.; Zelinski, Elizabeth M.; Willis, Sherry L.; Schaie, K. Warner; Johansson, Boo; Dixon, Roger A.; Mungas, Dan M.; Hofer, Scott M.; Piccinin, Andrea M. (Hindawi Publishing Corporation, 2012)Social activity is typically viewed as part of an engaged lifestyle that may help mitigate the deleterious effects of advanced age on cognitive function. As such, social activity has been examined in relation to cognitive ... -
Validity, Significance, Strengths, Limitations, and Evidentiary Value of Real-World Clinical Data for Combination Therapy in Alzheimer's Disease: Comparison of Efficacy and Effectiveness Studies
Atri, Alireza; Rountree, Susan D.; Lopez, Oscar L.; Doody, Rachelle S. (S. Karger AG, 2012)Background: Randomized controlled efficacy trials (RCTs), the scientific gold standard, are required for regulatory approval of Alzheimer's disease (AD) interventions, yet provide limited information regarding real-world ... -
A Web-Based Normative Calculator for the Uniform Data Set (UDS) Neuropsychological Test Battery
Shirk, Steven D; Weintraub, Sandra; Mitchell, Meghan B; Shaughnhessy, Lynn W; Sherman, Janet Cohen; Locascio, Joseph J; Atri, Alireza (BioMed Central, 2011)Introduction: With the recent publication of new criteria for the diagnosis of preclinical Alzheimer's disease (AD), there is a need for neuropsychological tools that take premorbid functioning into account in order to ...