Now showing items 1-20 of 21

    • The Aging Kidney: Increased Susceptibility to Nephrotoxicity 

      Wang, Xinhui; Bonventre, Joseph V.; Parrish, Alan R. (MDPI, 2014)
      Three decades have passed since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury. Data from these experimental models is strengthened by clinical data ...
    • Calcium in Renal Cells. Modulation of Calcium-dependent Activation of Phospholipase \(A_2\). 

      Bonventre, Joseph Vincent (U.S. Department of Health and Human Services, National Institute of Environmental Health Sciences, 1990)
      Calcium has been implicated as a regulatory factor in many physiological and pathophysiological processes in the renal cell. Under physiological conditions, the cytosolic free calcium concentration is maintained at ...
    • Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury 

      Antoine, Daniel J; Sabbisetti, Venkata S; Francis, Ben; Jorgensen, Andrea L; Craig, Darren GN; Simpson, Kenneth J; Bonventre, Joseph V; Park, B Kevin; Dear, James W (John Wiley & Sons, Ltd, 2015)
      Acute kidney injury in the context of acetaminophen (APAP; paracetamol)-induced liver injury is an important predictor of the requirement for urgent liver transplantation (LT) to avoid death. However, the prognostic biomarker ...
    • Cytosolic Phospholipase A2 Protein as a Novel Therapeutic Target for Spinal Cord Injury 

      Liu, Nai-Kui; Deng, Ling-Xiao; Zhang, Yi Ping; Lu, Qing-Bo; Wang, Xiao-Fei; Hu, Jian-Guo; Oakes, Eddie; Bonventre, Joseph V; Shields, Christopher B; Xu, Xiao-Ming (BlackWell Publishing Ltd, 2014)
      Objective: The objective of this study was to investigate whether cytosolic phospholipase A2 (cPLA2), an important isoform of PLA2 that mediates the release of arachidonic acid, plays a role in the pathogenesis of spinal ...
    • High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry 

      Hillion, Francois; McMahon, Greg; Benson, Douglas; Distel, Daniel; Luyten, Yvette; Schwartz, Martin; Slodzian, Georges; Lechene, Claude P.; Bonventre, Joseph Vincent; Hentschel, Dirk Manfred; Park, Kwon Moo; Ito, Susumu; Benichou, Gilles A.; Kleinfeld, Alan M.; Kampf, J. Patrick (BioMed Central, 2006)
      Background: Secondary-ion mass spectrometry (SIMS) is an important tool for investigating isotopic composition in the chemical and materials sciences, but its use in biology has been limited by technical considerations. ...
    • Increased plasma Kidney Injury Molecule-1 suggests early progressive renal decline in non-proteinuric patients with Type 1 diabetes 

      Nowak, Natalia; Skupien, Jan; Niewczas, Monika A.; Yamanouchi, Masayuki; Major, Melissa; Croall, Stephanie; Smiles, Adam; Warram, James H.; Bonventre, Joseph V.; Krolewski, Andrzej S. (2015)
      Progressively decreasing glomerular filtration rate (GFR), or renal decline, is seen in patients with type 1 diabetes (T1D) and normoalbuminuria or microalbuminuria. Here we examined the associations of kidney injury ...
    • Kim-1/Tim-1 and Immune Cells: Shifting Sands 

      Ichimura, Takaharu; Brooks, Craig; Bonventre, Joseph Vincent (Nature Publishing Group, 2012)
      Kim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory ...
    • Loss of Leucine-rich Repeat Kinase 2 Causes Age-dependent Bi-phasic Alterations of the Autophagy Pathway 

      Tong, Youren; Giaime, Emilie; Yamaguchi, Hiroo; Ichimura, Takaharu; Liu, Yumin; Si, Huiqing; Cai, Huaibin; Bonventre, Joseph Vincent; Shen, Jie (BioMed Central, 2012)
      Background: Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear. We previously ...
    • Mechanism-Based Urinary Biomarkers to Identify the Potential for Aminoglycoside-Induced Nephrotoxicity in Premature Neonates: A Proof-of-Concept Study 

      McWilliam, Stephen J.; Antoine, Daniel J.; Sabbisetti, Venkata S.; Turner, Mark A.; Farragher, Tracey; Bonventre, Joseph Vincent; Park, B. Kevin; Smyth, Rosalind L.; Pirmohamed, Munir (Public Library of Science, 2012)
      Premature infants are frequently exposed to aminoglycoside antibiotics. Novel urinary biomarkers may provide a non-invasive means for the early identification of aminoglycoside-related proximal tubule renal toxicity, to ...
    • Meclizine Preconditioning Protects the Kidney Against Ischemia–Reperfusion Injury 

      Kishi, Seiji; Campanholle, Gabriela; Gohil, Vishal M.; Perocchi, Fabiana; Brooks, Craig R.; Morizane, Ryuji; Sabbisetti, Venkata; Ichimura, Takaharu; Mootha, Vamsi K.; Bonventre, Joseph V. (Elsevier, 2015)
      Global or local ischemia contributes to the pathogenesis of acute kidney injury (AKI). Currently there are no specific therapies to prevent AKI. Potentiation of glycolytic metabolism and attenuation of mitochondrial ...
    • Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids 

      Freedman, Benjamin S.; Brooks, Craig R.; Lam, Albert Q.; Fu, Hongxia; Morizane, Ryuji; Agrawal, Vishesh; Saad, Abdelaziz F.; Li, Michelle K.; Hughes, Michael R.; Werff, Ryan Vander; Peters, Derek T.; Lu, Junjie; Baccei, Anna; Siedlecki, Andrew M.; Valerius, M. Todd; Musunuru, Kiran; McNagny, Kelly M.; Steinman, Theodore I.; Zhou, Jing; Lerou, Paul H.; Bonventre, Joseph V. (Nature Pub. Group, 2015)
      Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we ...
    • Nephron organoids derived from human pluripotent stem cells model kidney development and injury 

      Morizane, Ryuji; Lam, Albert Q.; Freedman, Benjamin S.; Kishi, Seiji; Valerius, M. Todd; Bonventre, Joseph V. (2015)
      Kidney cells and tissues derived from human pluripotent stem cells (hPSCs) would enable organ regeneration, disease modeling, and drug screening in vitro. We established an efficient, chemically defined protocol for ...
    • Primary proximal tubule injury leads to epithelial cell cycle arrest, fibrosis, vascular rarefaction, and glomerulosclerosis 

      Bonventre, Joseph V (Nature Publishing Group, 2014)
      Tubular injury has a major etiological role in fibrosis. For many years, this relationship has been dominated by the perception that epithelial cells are transformed into myofibroblasts that proliferate and generate fibrotic ...
    • The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation 

      Wang, Xiaowei; Shaw, Dana K.; Hammond, Holly L.; Sutterwala, Fayyaz S.; Rayamajhi, Manira; Shirey, Kari Ann; Perkins, Darren J.; Bonventre, Joseph V.; Velayutham, Thangam S.; Evans, Sean M.; Rodino, Kyle G.; VieBrock, Lauren; Scanlon, Karen M.; Carbonetti, Nicholas H.; Carlyon, Jason A.; Miao, Edward A.; McBride, Jere W.; Kotsyfakis, Michail; Pedra, Joao H. F. (Public Library of Science, 2016)
      Rickettsial agents are sensed by pattern recognition receptors but lack pathogen-associated molecular patterns commonly observed in facultative intracellular bacteria. Due to these molecular features, the order Rickettsiales ...
    • Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis 

      Besschetnova, Tatiana Y.; Ichimura, Takaharu; Katebi, Negin; St. Croix, Brad; Bonventre, Joseph V.; Olsen, Bjorn R. (2015)
      It is well known that angiogenesis is linked to fibrotic processes in fibroproliferative diseases, but insights into pathophysiological processes are limited, due to lack of understanding of molecular mechanisms controlling ...
    • RGS4 inhibits angiotensin II signaling and macrophage localization during renal reperfusion injury independent of vasospasm 

      Pang, Paul; Jin, Xiaohua; Proctor, Brandon M.; Farley, Michelle; Roy, Nilay; Chin, Matthew S.; von Andrian, Ulrich H.; Vollmann, Elisabeth; Perro, Mario; Hoffman, Ryan J.; Chung, Joseph; Chauhan, Nikita; Mistri, Murti; Muslin, Anthony J.; Bonventre, Joseph V.; Siedlecki, Andrew M. (2014)
      Vascular inflammation is a major contributor to the severity of acute kidney injury. In the context of vasospasm-independent reperfusion injury we studied the potential anti-inflammatory role of the Gα-related RGS protein, ...
    • Secreted Factors from Bone Marrow Stromal Cells Upregulate IL-10 and Reverse Acute Kidney Injury 

      Yarmush, Joshua S.; Milwid, John Miles; Ichimura, Takaharu; Li, Matthew; Jiao, Joy; Lee, Jungwoo; Parekkadan, Biju; Tilles, Arno W.; Bonventre, Joseph Vincent; Yarmush, Martin Leon (Hindawi Publishing Corporation, 2012)
      Acute kidney injury is a devastating syndrome that afflicts over 2,000,000 people in the US per year, with an associated mortality of greater than 70% in severe cases. Unfortunately, standard-of-care treatments are not ...
    • Some Biomarkers of Acute Kidney Injury Are Increased in Pre-Renal Acute Injury 

      Nejat, Maryam; Pickering, John W; Devarajan, Prasad; Bonventre, Joseph Vincent; Edelstein, Charles L; Walker, Robert J; Endre, Zoltán H (Nature Publishing Group, 2012)
      Pre-renal acute kidney injury (AKI) is assumed to represent a physiological response to underperfusion. Its diagnosis is retrospective after a transient rise in plasma creatinine, usually associated with evidence of altered ...
    • Targeted Proximal Tubule Injury Triggers Interstitial Fibrosis and Glomerulosclerosis 

      Grgic, Ivica; Campanholle, Gabriela; Bijol, Vanesa; Wang, Chang; Sabbisetti, Venkata S; Ichimura, Takaharu; Humphreys, Benjamin D.; Bonventre, Joseph Vincent (Nature Publishing Group, 2012)
      Chronic kidney disease (CKD) remains one of the leading causes of death in the developed world and acute kidney injury (AKI) is now recognized as a major risk factor in its development. Understanding the factors leading ...
    • TRIP-Br2 Promotes Oncogenesis in Nude Mice and is Frequently Overexpressed in Multiple Human Tumors 

      Cheong, Jit Kong; Gunaratnam, Lakshman; Zang, Zhi Jiang; Yang, Christopher M; Nasr, Susan L; Sim, Khe Guan; Peh, Bee Keow; Rashid, Suhaimi Bin Abdul; Salto-Tellez, Manuel; Hsu, Stephen I; Sun, Xiaoming; Bonventre, Joseph Vincent (BioMed Central, 2009)
      Background: Members of the TRIP-Br/SERTAD family of mammalian transcriptional coregulators have recently been implicated in E2F-mediated cell cycle progression and tumorigenesis. We, herein, focus on the detailed functional ...