Now showing items 1-5 of 5

    • BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles 

      Chen, Walter W; Balaj, Leonora; Liau, Linda M; Samuels, Michael L; Kotsopoulos, Steve K; Maguire, Casey A; LoGuidice, Lori; Soto, Horacio; Garrett, Matthew; Zhu, Lin Dan; Sivaraman, Sarada; Chen, Clark; Wong, Eric T; Carter, Bob S; Hochberg, Fred H; Breakefield, Xandra O; Skog, Johan (Nature Publishing Group, 2013)
      Development of biofluid-based molecular diagnostic tests for cancer is an important step towards tumor characterization and real-time monitoring in a minimally invasive fashion. Extracellular vesicles (EVs) are released ...
    • Impact of Biofluid Viscosity on Size and Sedimentation Efficiency of the Isolated Microvesicles 

      Momen-Heravi, Fatemeh; Balaj, Leonora; Alian, Sara; Trachtenberg, Alexander J.; Hochberg, Fred Harvey; Skog, Johan; Kuo, Winston Patrick (Frontiers Research Foundation, 2012)
      Microvesicles are nano-sized lipid vesicles released by all cells in vivo and in vitro. They are released physiologically under normal conditions but their rate of release is higher under pathological conditions such as ...
    • miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma Biomarker Development 

      Akers, Johnny C.; Ramakrishnan, Valya; Kim, Ryan; Skog, Johan; Nakano, Ichiro; Pingle, Sandeep; Kalinina, Juliya; Hua, Wei; Kesari, Santosh; Mao, Ying; Breakefield, Xandra O.; Hochberg, Fred H.; Van Meir, Erwin G.; Carter, Bob S.; Chen, Clark C. (Public Library of Science, 2013)
      Glioblastoma cells secrete extra-cellular vesicles (EVs) containing microRNAs (miRNAs). Analysis of these EV miRNAs in the bio-fluids of afflicted patients represents a potential platform for biomarker development. However, ...
    • Phase II Study of Cediranib, an Oral Pan–Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent Glioblastoma 

      Batchelor, Tracy Todd; Duda, Dan Gabriel; di Tomaso, Emmanuelle; Ancukiewicz, Marek; Plotkin, Scott Randall; Gerstner, Elizabeth Robins; Eichler, April Fitzsimmons; Drappatz, Jan; Hochberg, Fred; Benner, Thomas; Louis, David N.; Cohen, Kenneth S.; Chea, Houng; Exarhopoulos, Alexis; Loeffler, Jay Steven; Moses, Marsha; Ivy, Percy; Sorensen, A; Wen, Patrick Yung Chih; Jain, Rakesh K. (American Society of Clinical Oncology (ASCO), 2010)
      Purpose Glioblastoma is an incurable solid tumor characterized by increased expression of vascular endothelial growth factor (VEGF). We performed a phase II study of cediranib in patients with recurrent glioblastoma. ...
    • RNA Expression Patterns in Serum Microvesicles from Patients with Glioblastoma Multiforme and Controls 

      Noerholm, Mikkel; Balaj, Leonora; Limperg, Tobias; Salehi, Afshin; Zhu, Lin Dan; Hochberg, Fred Harvey; Breakefield, Xandra Owens; Carter, Bob S; Skog, Johan (BioMed Central, 2012)
      Background: RNA from exosomes and other microvesicles contain transcripts of tumour origin. In this study we sought to identify biomarkers of glioblastoma multiforme in microvesicle RNA from serum of affected patients. ...