Browsing by Author "Franks, Alexander M."
Now showing items 1-4 of 4
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Accounting for Experimental Noise Reveals That mRNA Levels, Amplified by Post-Transcriptional Processes, Largely Determine Steady-State Protein Levels in Yeast
Csárdi, Gábor; Franks, Alexander; Choi, David S.; Airoldi, Edoardo M.; Drummond, D. Allan (Public Library of Science, 2015)Cells respond to their environment by modulating protein levels through mRNA transcription and post-transcriptional control. Modest observed correlations between global steady-state mRNA and protein measurements have been ... -
Quantifying Sources of Variation in High-throughput Biology
Franks, Alexander M. (2015-05-07)One of the central challenges in systems biology research is disentangling relevant and irrelevant sources of variation. While the relevant quantities are always context dependent, an important distinction can be drawn ... -
Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress
Wallace, Edward W.J.; Kear-Scott, Jamie L.; Pilipenko, Evgeny V.; Schwartz, Michael H.; Laskowski, Pawel R.; Rojek, Alexandra E.; Katanski, Christopher D.; Riback, Joshua A.; Dion, Michael F.; Franks, A; Airoldi, Edoardo Maria; Pan, Tao; Budnik, Bogdan; Drummond, D. Allan (Elsevier BV, 2015)Heat causes protein misfolding and aggregation, and in eukaryotic cells triggers aggregation of proteins and RNA into stress granules. We have carried out extensive proteomic studies to quantify heat-triggered aggregation ... -
A Solution to the Challenge of Optimization on ''Golf-Course''-Like Fitness Landscapes
Melo, Hygor Piaget M.; Franks, Alexander; Moreira, André A.; Diermeier, Daniel; Andrade, José S.; Amaral, Luís A. N. u. n. e. s. (Public Library of Science, 2013)Genetic algorithms (GAs) have been used to find efficient solutions to numerous fundamental and applied problems. While GAs are a robust and flexible approach to solve complex problems, there are some situations under which ...