Now showing items 1-20 of 232

    • A 3D interactive multi-object segmentation tool using local robust statistics driven active contours 

      Gao, Yi; Kikinis, Ron; Bouix, Sylvain; Shenton, Martha Elizabeth; Tannenbaum, Allen (Elsevier BV, 2012)
      Extracting anatomical and functional significant structures renders one of the important tasks for both the theoretical study of the medical image analysis, and the clinical and practical community. In the past, much work ...
    • Aberrant semantic activation in schizophrenia: a neurophysiological study 

      Nestor, PG; Kimble, MO; O'Donnell, BF; Smith, L; Niznikiewicz, Margaret A.; Shenton, Martha Elizabeth; McCarley, RW (American Psychiatric Publishing, 1997)
      OBJECTIVE: Schizophrenia has long been thought to be characterized by a fundamental disturbance in semantic associations, which has often been presumed to be of neurobiological origin. The authors examined the neurophysiological ...
    • Abnormal Angular Gyrus Asymmetry in Schizophrenia 

      Niznikiewicz, Margaret A.; Donnino, Robert; McCarley, Robert William; Nestor, Paul Gerard; Iosifescu, Daniel V.; O'Donnell, Brian; Levitt, James Jonathan; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2000)
      Objective: Few studies have evaluated the parietal lobe in schizophrenia despite the fact that it has an important role in attention, memory, and language—all functions that have been reported to be abnormal in schizophrenia. ...
    • Abnormal Neural Synchrony in Schizophrenia 

      Spencer, Kevin M.; Nestor, Paul Gerard; Niznikiewicz, Margaret A.; Salisbury, Dean F.; Shenton, Martha Elizabeth; McCarley, Robert William (2003)
      Schizophrenia has been conceptualized as a failure of cognitive integration, and abnormalities in neural circuitry (particularly inhibitory interneurons) have been proposed as a basis for this disorder. We used measures ...
    • Abnormal pitch mismatch negativity in individuals with schizotypal personality disorder 

      Niznikiewicz, Margaret A.; Spencer, Kevin M.; Dickey, Chandlee C.; Voglmaier, Martina M.; Seidman, Larry Joel; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2009)
      Background: The goal of the study was to examine mismatch negativity (MMN) in schizotypal personality disorder (SPD) individuals. Abnormal MMN has been a consistent finding in chronic schizophrenia and there are also have ...
    • Abnormal white matter microstructure and increased extracellular free-water in the cingulum bundle associated with delusions in chronic schizophrenia 

      Oestreich, Lena K.L.; Pasternak, Ofer; Shenton, Martha E.; Kubicki, Marek; Gong, Xue; McCarthy-Jones, Simon; Whitford, Thomas J. (Elsevier, 2016)
      Background: There is growing evidence to suggest that delusions associated with schizophrenia arise from altered structural brain connectivity. The present study investigated whether structural changes in three major ...
    • Abnormalities of middle longitudinal fascicle and disorganization in patients with schizophrenia 

      Asami, Takeshi; Saito, Yukiko; Whitford, Thomas; Makris, Nikos; Niznikiewicz, Margaret A.; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Elsevier BV, 2013)
      Introduction—The Middle Longitudinal Fascicle (MdLF) is a long association fiber connecting the superior temporal gyrus (STG) and temporal pole with the angular gyrus through the white matter of the STG, structures which ...
    • Abnormalities of the Left Temporal Lobe and Thought Disorder in Schizophrenia 

      Shenton, Martha Elizabeth; Kikinis, Ron; Jolesz, Ferenc A.; Pollak, Seth D.; Lemay, Marjorie Jeannette; Wible, Cynthia Gayle; Hokama, Hiroto; Martin, John; Metcalf, Dave; Coleman, Michael James; McCarley, Robert William (New England Journal of Medicine (NEJM/MMS), 1992)
      BACKGROUND: Data from postmortem, CT, and magnetic resonance imaging (MRI) studies indicate that patients with schizophrenia may have anatomical abnormalities of the left temporal lobe, but it is unclear whether these ...
    • Age-related decline in white matter tract integrity and cognitive performance: A DTI tractography and structural equation modeling study 

      Voineskos, Aristotle N.; Rajji, Tarek K.; Lobaugh, Nancy J.; Miranda, Dielle; Shenton, Martha Elizabeth; Kennedy, James L.; Pollock, Bruce G.; Mulsant, Benoit H. (Elsevier BV, 2012)
      Age-related decline in microstructural integrity of certain white matter tracts may explain cognitive decline associated with normal aging. Whole brain tractography and a clustering segmentation in 48 healthy individuals ...
    • Alterations in brain structures underlying language function in young adults at high familial risk for schizophrenia 

      Francis, Alan N; Seidman, Larry Joel; Jabbar, Gul A.; Mesholam-Gately, Raquelle; Thermenos, Heidi Wencel; Juelich, Richard; Proal, Ashley; Shenton, Martha Elizabeth; Kubicki, Marek R.; Mathew, Ian; Keshavan, Matcheri S; DeLisi, Lynn E (Elsevier BV, 2012)
      Introduction—Neuroanatomical and cognitive alterations typical of schizophrenia (SZ) patients are observed to a lesser extent in their adolescent and adult first-degree relatives, likely reflecting neurodevelopmental ...
    • Altered language network activity in young people at familial high-risk for schizophrenia 

      Thermenos, Heidi Wencel; Whitfield-Gabrieli, S.; Seidman, Larry Joel; Kuperberg, Gina Rosalind; Juelich, R.J.; Divatia, S.; Riley, C.; Jabbar, G.A.; Shenton, Martha Elizabeth; Kubicki, Marek R.; Manschreck, Theo Clyde; Keshavan, Matcheri S; DeLisi, Lynn E (Elsevier BV, 2013)
      Background—Abnormalities in language and language neural circuitry are observed in schizophrenia (SZ). Similar, but less pronounced language deficits are also seen in young first degree relatives of people with SZ, who ...
    • Altered orbitofrontal sulcogyral pattern in schizophrenia 

      Nakamura, M.; Nestor, Paul Gerard; McCarley, Robert William; Levitt, James Jonathan; Hsu, Liangge; Kawashima, T.; Niznikiewicz, Margaret A.; Shenton, Martha Elizabeth (Oxford University Press (OUP), 2007)
      Orbitofrontal alteration in schizophrenia has not been well characterized, likely due to marked anatomical variability. To investigate the presence of such alterations, we evaluated the sulcogyral pattern of this ‘H-shaped’ ...
    • Amygdala–hippocampal shape differences in schizophrenia: the application of 3D shape models to volumetric MR data 

      Shenton, Martha Elizabeth; Gerig, Guido; McCarley, Robert William; Székely, Gábor; Kikinis, Ron (Elsevier BV, 2002)
      Evidence suggests that some structural brain abnormalities in schizophrenia are neurodevelopmental in origin. There is also growing evidence to suggest that shape deformations in brain structure may reflect abnormalities ...
    • Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds 

      del Re, E C; Bergen, S E; Mesholam-Gately, R I; Niznikiewicz, M A; Goldstein, J M; Woo, T U; Shenton, Martha E.; Seidman, L J; McCarley, R W; Petryshen, T L (Nature Publishing Group, 2014)
      Several genes have recently been identified as risk factors for schizophrenia (SZ) by genome-wide association studies (GWAS), including ZNF804A which is thought to function in transcriptional regulation. However, the ...
    • Anisotropy of transcallosal motor fibres indicates functional impairment in children with periventricular leukomalacia 

      Koerte, Inga Katharina; Pelavin, Paula; Kirmess, Berit; Fuchs, Teresa; Berweck, Steffen; Laubender, Ruediger P; Borggraefe, Ingo; Schroeder, Sebastian; Danek, Adrian; Rummeny, Caludia; Reiser, Maximilian; Kubicki, Marek R.; Shenton, Martha Elizabeth; Ertl-Wagner, Birgit; Heinen, Florian (Wiley-Blackwell, 2010)
      Aim—In children with bilateral spastic cerebral palsy (CP), periventricular leukomalacia (PVL) is commonly identified on magnetic resonance imaging. We characterized this white matter condition by examining callosal ...
    • Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography study 

      Rosenberger, Gudrun; Nestor, Paul Gerard; Oh, Jungsu S.; Levitt, James Jonathan; Kindleman, Gordon; Bouix, Sylvain; Fitzsimmons, Jennifer J; Niznikiewicz, Margaret A.; Westin, Carl-Fredrik; Kikinis, Ron; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Springer Science + Business Media, 2012)
      Thalamo-cortical feedback loops play a key role in the processing and coordination of processing and integration of perceptual inputs and outputs, and disruption in this connection has long been hypothesized to contribute ...
    • The Application of DTI to Investigate White Matter Abnormalities in Schizophrenia 

      Kubicki, Marek R.; Westin, Carl-Fredrik; McCarley, Robert William; Shenton, Martha Elizabeth (Wiley-Blackwell, 2005)
      Schizophrenia is a serious and disabling mental disorder that affects approximately 1% of the general population, with often devastating effects on the psychological and financial resources of the patient, family, and ...
    • Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression 

      Bergamino, Maurizio; Pasternak, Ofer; Farmer, Madison; Shenton, Martha E.; Paul Hamilton, J. (Elsevier, 2015)
      Diffusion tensor imaging (DTI) holds promise for developing our understanding of white-matter pathology in major depressive disorder (MDD). Variable findings in DTI-based investigations of MDD, however, have thwarted ...
    • Association Between Reduced Extraversion and Right Posterior Fusiform Gyrus Gray Matter Reduction in Chronic Schizophrenia 

      Onitsuka, Toshiaki; Nestor, Paul Gerard; Gurrera, Ronald Joseph; Shenton, Martha Elizabeth; Kasai, Kiyoto; Frumin, Melissa; Niznikiewicz, Margaret A.; McCarley, Robert William (American Psychiatric Publishing, 2005)
      Objective: The authors examined the association between volume of the fusiform gyrus, a region involved in face processing, and the personality trait of extraversion in patients with schizophrenia. Method: Male patients ...
    • Associative memory in chronic schizophrenia: a computational model 

      Han, S Duke; Nestor, Paul Gerard; Shenton, Martha Elizabeth; Niznikiewicz, Margaret A.; Hannah, Gordon; McCarley, Robert William (Elsevier BV, 2003)
      We developed a computer model to simulate associative memory recall of patients with chronic schizophrenia. Model inputs consisted of words derived from normative data that differed in terms of connectivity and network ...