Now showing items 1-15 of 15

    • Burn injury differentially alters whole-blood and organ glutathione synthesis rates: An experimental model 

      Fei, Zhe-Wei; Young, Vernon R.; Lu, Xiao-Ming; Rhodes, Andrew B.; Tompkins, Ronald G.; Fischman, Alan J.; Yu, Yong-Ming (BioMed Central, 2013)
      Previous studies from our laboratories revealed a reduced rate of whole-blood (WB) glutathione (GSH) synthesis in severely burned patients. To determine whether WB GSH metabolism is an indicator of the status of GSH ...
    • Burn Injury Reduces Neutrophil Directional Migration Speed in Microfluidic Devices 

      Butler, Kathryn Lee; Ambravaneswaran, Vijayakrishnan; Agrawal, Nitin; Bilodeau, Maryelizabeth; Toner, Mehmet; Tompkins, Ronald Gary; Fagan, Shawn P.; Irimia, Daniel (Public Library of Science, 2010)
      Thermal injury triggers a fulminant inflammatory cascade that heralds shock, end-organ failure, and ultimately sepsis and death. Emerging evidence points to a critical role for the innate immune system, and several studies ...
    • A Genomic Storm in Critically Injured Humans 

      Mindrinos, Michael N.; Seok, Junhee; Cuschieri, Joseph; Cuenca, Alex G.; Hayden, Douglas L.; Hennessy, Laura; Moore, Ernest E.; Minei, Joseph P.; Bankey, Paul E.; Sperry, Jason; Nathens, Avery B.; Billiar, Timothy R.; Brownstein, Bernard H.; Mason, Philip H.; Baker, Henry V.; Finnerty, Celeste C.; Jeschke, Marc G.; López, M. Cecilia; Klein, Matthew B.; Gamelli, Richard L.; Gibran, Nicole S.; Arnoldo, Brett; Xu, Weihong; Zhang, Yuping; Calvano, Steven E.; McDonald-Smith, Grace P.; Storey, John D.; Moldawer, Lyle L.; Herndon, David N.; Lowry, Stephen F.; Maier, Ronald V.; Davis, Ronald W.; Xiao, Wenzhong; Gao, Hong; Johnson, Jeffrey L.; West, Michael A.; Schoenfeld, David Alan; Cobb, Joseph Perren; Warren, H. Shaw; Tompkins, Ronald Gary (The Rockefeller University Press, 2011)
      Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well as in healthy subjects receiving low-dose ...
    • Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth 

      Hamrahi, Victoria; Hamblin, Michael; Jung, Walter; Benjamin, John B.; Paul, Kasie W.; Fischman, Alan J.; Tompkins, Ronald Gary; Carter, Edward Albert (Hindawi Publishing Corporation, 2012)
      Sepsis remains the major cause of death in patients with major burn injuries. In the present investigation we evaluated the interaction between burn injuries of varying severity and preexisting distant infection. We used ...
    • Inhibitors of Pathogen Intercellular Signals as Selective Anti-Infective Compounds 

      Lesic, Biliana; Lépine, François; Déziel, Eric; Zhang, Qunhao; Padfield, Katie; Castonguay, Marie-Hélène; Milot, Sylvain; Stachel, Scott; Zhang, Jiangwen; Tzika, A. Aria; Tompkins, Ronald Gary; Rahme, Laurence G. (Public Library of Science, 2007)
      Long-term antibiotic use generates pan-resistant super pathogens. Anti-infective compounds that selectively disrupt virulence pathways without affecting cell viability may be used to efficiently combat infections caused ...
    • Integration of Architectural and Cytologic Driven Image Algorithms for Prostate Adenocarcinoma Identification 

      Hipp, Jason; Monaco, James; Kunju, L. Priya; Cheng, Jerome; Yagi, Yukako; Rodriguez-Canales, Jaime; Emmert-Buck, Michael R.; Hewitt, Stephen; Feldman, Michael D.; Tomaszewski, John E.; Toner, Mehmet; Tompkins, Ronald G.; Flotte, Thomas; Lucas, David; Gilbertson, John R.; Madabhushi, Anant; Balis, Ulysses (IOS Press, 2012)
      Introduction:: The advent of digital slides offers new opportunities within the practice of pathology such as the use of image analysis techniques to facilitate computer aided diagnosis (CAD) solutions. Use of CAD holds ...
    • Involvement of Skeletal Muscle Gene Regulatory Network in Susceptibility to Wound Infection Following Trauma 

      Apidianakis, Yiorgos; Mindrinos, Michael N.; Xiao, Wenzhong; Tegos, George; Papisov, Mikhail Ivanovich; Hamblin, Michael; Davis, Ronald W.; Tompkins, Ronald Gary; Rahme, Laurence G. (Public Library of Science, 2007)
      Despite recent advances in our understanding the pathophysiology of trauma, the basis of the predisposition of trauma patients to infection remains unclear. A Drosophila melanogaster/Pseudomonas aeruginosa injury and ...
    • KERIS: kaleidoscope of gene responses to inflammation between species 

      Li, Peng; Tompkins, Ronald G; Xiao, Wenzhong (Oxford University Press, 2017)
      A cornerstone of modern biomedical research is the use of animal models to study disease mechanisms and to develop new therapeutic approaches. In order to help the research community to better explore the similarities and ...
    • Nitric Oxide Activates Intradomain Disulfide Bond Formation in the Kinase Loop of Akt1/PKBα after Burn Injury 

      Lu, Xiaoming; Tompkins, Ronald Gary; FISCHMAN, A.J. (D.A. Spandidos, 2013)
      Severe burn injury is an acute inflammatory state with massive alterations in gene expression and levels of growth factors, cytokines and free radicals. During the catabolic processes, changes in insulin sensitivity and ...
    • Prediction of Multiple Infections After Severe Burn Trauma 

      Yan, Shuangchun; Tsurumi, Amy; Que, Yok-Ai; Ryan, Colleen M.; Bandyopadhaya, Arunava; Morgan, Alexander A.; Flaherty, Patrick J.; Tompkins, Ronald Gary; Rahme, Laurence G. (Ovid Technologies (Wolters Kluwer Health), 2015)
      OBJECTIVE: To develop predictive models for early triage of burn patients based on hypersusceptibility to repeated infections. BACKGROUND: Infection remains a major cause of mortality and morbidity after severe trauma, ...
    • The Quorum Sensing Volatile Molecule 2-Amino Acetophenon Modulates Host Immune Responses in a Manner that Promotes Life with Unwanted Guests 

      Bandyopadhaya, Arunava; Kesarwani, Meenu; Que, Yok-Ai; He, Jianxin; Padfield, Katie; Tompkins, Ronald Gary; Rahme, Laurence G. (Public Library of Science, 2012)
      Increasing evidence indicates that bacterial quorum sensing (QS) signals are important mediators of immunomodulation. However, whether microbes utilize these immunomodulatory signals to maintain infection remain unclear. ...
    • Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle 

      Nakazawa, Harumasa; Yamada, Marina; Tanaka, Tomokazu; Kramer, Joshua; Yu, Yong-Ming; Fischman, Alan J.; Martyn, J. A. Jeevendra; Tompkins, Ronald G.; Kaneki, Masao (Public Library of Science, 2015)
      Objective: Metabolic derangements, including insulin resistance and hyperlactatemia, are a major complication of major trauma (e.g., burn injury) and affect the prognosis of burn patients. Protein farnesylation, a ...
    • A Small Volatile Bacterial Molecule Triggers Mitochondrial Dysfunction in Murine Skeletal Muscle 

      Tzika, A. Aria; Constantinou, Caterina; Bandyopadhaya, Arunava; Psychogios, Nikolaos; Lee, Sangseok; Mindrinos, Michael; Martyn, J. A. Jeevendra; Tompkins, Ronald G.; Rahme, Laurence G. (Public Library of Science, 2013)
      Mitochondria integrate distinct signals that reflect specific threats to the host, including infection, tissue damage, and metabolic dysfunction; and play a key role in insulin resistance. We have found that the Pseudomonas ...
    • Spontaneous Neutrophil Migration Patterns during Sepsis after Major Burns 

      Jones, Caroline N.; Moore, Molly; Dimisko, Laurie; Alexander, Andrew; Ibrahim, Amir; Hassell, Bryan A.; Warren, H. Shaw; Tompkins, Ronald G.; Fagan, Shawn P.; Irimia, Daniel (Public Library of Science, 2014)
      Finely tuned to respond quickly to infections, neutrophils have amazing abilities to migrate fast and efficiently towards sites of infection and inflammation. Although neutrophils ability to migrate is perturbed in patients ...
    • TNF-α/IL-10 Ratio Correlates with Burn Severity and May Serve as a Risk Predictor of Increased Susceptibility to Infections 

      Tsurumi, Amy; Que, Yok-Ai; Ryan, Colleen M.; Tompkins, Ronald G.; Rahme, Laurence G. (Frontiers Media S.A., 2016)
      Severe burn injury renders patients susceptible to multiple infection episodes; however, identifying specific patient groups at high risk remains challenging. Burn-induced inflammatory response dramatically modifies the ...