Now showing items 1-5 of 5

    • Bioorthogonal Small Molecule Imaging Agents Allow Single-Cell Imaging of MET 

      Kim, Eunha; Yang, Katherine S.; Weissleder, Ralph (Public Library of Science, 2013)
      The hepatocyte growth factor receptor (MET) is a receptor tyrosine kinase (RTK) that has emerged as an important cancer target. Consequently, a number of different inhibitors varying in specificity are currently in clinical ...
    • Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response 

      Giedt, Randy J.; Fumene Feruglio, Paolo; Pathania, Divya; Yang, Katherine S.; Kilcoyne, Aoife; Vinegoni, Claudio; Mitchison, Timothy J.; Weissleder, Ralph (Nature Publishing Group, 2016)
      Mitochondria, which are essential organelles in resting and replicating cells, can vary in number, mass and shape. Past research has primarily focused on short-term molecular mechanisms underlying fission/fusion. Less is ...
    • Imaging Cellular Distribution of Bcl Inhibitors Using Small Molecule Drug Conjugates 

      Giedt, Randy J.; Sprachman, Melissa M.; Yang, Katherine S.; Weissleder, Ralph (American Chemical Society, 2014)
      Overexpression of anti-apoptotic proteins such as Bcl-2 is a cellular mechanism to evade apoptosis; consequently, Bcl-2 inhibitors are being developed as anticancer agents. In this work, we have synthesized a fluorescent ...
    • Single cell resolution in vivo imaging of DNA damage following PARP inhibition 

      Yang, Katherine S.; Kohler, Rainer H.; Landon, Matthieu; Giedt, Randy; Weissleder, Ralph (Nature Publishing Group, 2015)
      Targeting DNA repair pathways is a powerful strategy to treat cancers. To gauge efficacy in vivo, typical response markers include late stage effects such as tumor shrinkage, progression free survival, or invasive repeat ...
    • Tumor associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug 

      Miller, Miles A.; Zheng, Yao-Rong; Gadde, Suresh; Pfirschke, Christina; Zope, Harshal; Engblom, Camilla; Kohler, Rainer H.; Iwamoto, Yoshiko; Yang, Katherine S.; Askevold, Bjorn; Kolishetti, Nagesh; Pittet, Mikael; Lippard, Stephen J.; Farokhzad, Omid C.; Weissleder, Ralph (2015)
      Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral ...