Now showing items 1-5 of 5

    • ARF1 and GBF1 Generate a PI4P-Enriched Environment Supportive of Hepatitis C Virus Replication 

      Zhang, Leiliang; Hong, Zhi; Lin, Wenyu; Shao, Run-Xuan; Goto, Kaku; Hsu, Victor Wee; Chung, Raymond Taeyong (Public Library of Science, 2012)
      Cellular levels of phosphatidylinositol 4-phosphate (PI4P) have been shown to be upregulated during RNA replication of several viruses, including the HCV replicon model. However, whether PI4P is required in an infectious ...
    • Coordinated regulation of bidirectional COPI transport at the Golgi by cdc42 

      Park, Seung-Yeol; Yang, Jia-Shu; Schmider, Angela B.; Soberman, Roy J.; Hsu, Victor W. (2015)
      The Golgi complex plays a central role in the intracellular sorting of secretory proteins 1,2. Anterograde transport through the Golgi has been explained by the movement of Golgi cisternae, known as cisternal maturation ...
    • The Protein Kinase Akt Acts as a Coat Adaptor in Endocytic Recycling 

      Hsu, Jia-Wei; Bai, Ming; Li, Kunhua; Yang, Jia-Shu; Chu, Nam; Cole, Philip; Eck, Michael J.; Li, Jian; Hsu, Victor (Springer Science and Business Media LLC, 2020-06-15)
      Coat proteins play a central role in vesicular transport by binding to cargoes for their sorting into intracellular pathways. Cargo recognition is mediated by components of the coat complex known as adaptor proteins. We ...
    • A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair 

      Encarnação, Marisa; Espada, Lília; Escrevente, Cristina; Mateus, Denisa; Ramalho, José; Michelet, Xavier; Santarino, Inês; Hsu, Victor W.; Brenner, Michael B.; Barral, Duarte C.; Vieira, Otília V. (The Rockefeller University Press, 2016)
      Lysosome exocytosis plays a major role in resealing plasma membrane (PM) disruptions. This process involves two sequential steps. First, lysosomes are recruited to the periphery of the cell and then fuse with the damaged ...
    • Structural characterization of coatomer in its cytosolic state 

      Wang, Shengliu; Zhai, Yujia; Pang, Xiaoyun; Niu, Tongxin; Ding, Yue-He; Dong, Meng-Qiu; Hsu, Victor W.; Sun, Zhe; Sun, Fei (Higher Education Press, 2016)
      Studies on coat protein I (COPI) have contributed to a basic understanding of how coat proteins generate vesicles to initiate intracellular transport. The core component of the COPI complex is coatomer, which is a multimeric ...