Browsing by Author "Lee, Yoonjin"

Now showing items 1-2 of 2

    • A Chemical Approach Identifies CDK4 as a Regulatory Component of Glucose Metabolism 

      Lee, Yoonjin (2014-06-06)
      Mammals have to adapt quickly to the changes of nutrition availability. The liver is the central organ that coordinates the responses to food deprivation upon fasting and nutrient overload during feeding. In liver, hormonal ...

    • Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression 

      Lee, Yoonjin; Dominy, John E.; Choi, Yoon Jong; Jurczak, Michael; Tolliday, Nicola; Camporez, Joao Paulo; Chim, Helen; Lim, Ji-Hong; Ruan, Hai-Bin; Yang, Xiaoyong; Vazquez, Francisca; Sicinski, Piotr; Shulman, Gerald I.; Puigserver, Pere (2014)
      Insulin constitutes a major evolutionarily conserved hormonal axis for maintaining glucose homeostasis1-3; dysregulation of this axis causes diabetes2,4. PGC-1α links insulin signaling to the expression of glucose and lipid ...