Now showing items 1-2 of 2

    • The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis 

      Carrasco, Daniel R.; Sukhdeo, Kumar; Protopopova, Marina; Enos, Miriam; Zheng, Mei; Mani, Mala; Ivanova, Elena V.; Tonon, Giovanni; Sinha, Raktim; Carrasco, Daniel E.; Henderson, Joel Michael; Pinkus, Geraldine Sowinski; Munshi, Nikhil C; Horner, James W.; Protopopov, Alexei; Anderson, Kenneth Carl; DePinho, Ronald A. (Cell Press, 2007)
      Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are unknown. We report a MGUS/MM phenotype in transgenic mice with ...
    • Somatic p16INK4a Loss Accelerates Melanomagenesis 

      Monahan, K B; Rozenberg, G I; Krishnamurthy, J; Johnson, S M; Liu, W; Bradford, M K; Horner, James W.; DePinho, Ronald A.; Sharpless, N E (Nature Publishing Group, 2010)
      Loss of p16\(^{INK4a}–RB\) and ARF–p53 tumor suppressor pathways, as well as activation of RAS–RAF signaling, is seen in a majority of human melanomas. Although heterozygous germline mutations of p16\(^{INK4a}\) are ...