Now showing items 1-7 of 7

    • Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model 

      Obaldía III, Nicanor; Dow, Geoffrey S.; Gerena, Lucia; Kyle, Dennis; Otero, William; Mantel, Pierre-Yves; Baro, Nicholas; Daniels, Rachel; Mukherjee, Angana; Childs, Lauren M.; Buckee, Caroline; Duraisingh, Manoj T.; Volkman, Sarah K.; Wirth, Dyann F.; Marti, Matthias (Nature Publishing Group, 2016)
      Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based combination therapies. However, artemisinin resistant parasites have ...
    • CRISPR-Induced Distributed Immunity in Microbial Populations 

      Childs, Lauren M.; England, Whitney E.; Young, Mark J.; Weitz, Joshua S.; Whitaker, Rachel J. (Public Library of Science, 2014)
      In bacteria and archaea, viruses are the primary infectious agents, acting as virulent, often deadly pathogens. A form of adaptive immune defense known as CRISPR-Cas enables microbial cells to acquire immunity to viral ...
    • Dissecting the determinants of malaria chronicity: why within-host models struggle to reproduce infection dynamics 

      Childs, Lauren M.; Buckee, Caroline O. (The Royal Society, 2015)
      The duration of infection is fundamental to the epidemiological behaviour of any infectious disease, but remains one of the most poorly understood aspects of malaria. In endemic areas, the malaria parasite Plasmodium ...
    • Targeting Human Transmission Biology for Malaria Elimination 

      Nilsson, Sandra K.; Childs, Lauren M.; Buckee, Caroline; Marti, Matthias (Public Library of Science, 2015)
      Malaria remains one of the leading causes of death worldwide, despite decades of public health efforts. The recent commitment by many endemic countries to eliminate malaria marks a shift away from programs aimed at controlling ...
    • Trade-offs in antibody repertoires to complex antigens 

      Childs, Lauren M.; Baskerville, Edward B.; Cobey, Sarah (The Royal Society, 2015)
      Pathogens vary in their antigenic complexity. While some pathogens such as measles present a few relatively invariant targets to the immune system, others such as malaria display considerable antigenic diversity. How the ...
    • Variation in infection length and superinfection enhance selection efficiency in the human malaria parasite 

      Chang, Hsiao-Han; Childs, Lauren M.; Buckee, Caroline O. (Nature Publishing Group, 2016)
      The capacity for adaptation is central to the evolutionary success of the human malaria parasite Plasmodium falciparum. Malaria epidemiology is characterized by the circulation of multiple, genetically diverse parasite ...
    • Wolbachia infections in natural Anopheles populations affect egg laying and negatively correlate with Plasmodium development 

      Shaw, W. Robert; Marcenac, Perrine; Childs, Lauren M.; Buckee, Caroline O.; Baldini, Francesco; Sawadogo, Simon P.; Dabiré, Roch K.; Diabaté, Abdoulaye; Catteruccia, Flaminia (Nature Publishing Group, 2016)
      The maternally inherited alpha-proteobacterium Wolbachia has been proposed as a tool to block transmission of devastating mosquito-borne infectious diseases like dengue and malaria. Here we study the reproductive manipulations ...