Now showing items 1-12 of 12

    • Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells 

      Li, Chenggang; Lee, Po-Shun; Sun, Yang; Gu, Xiaoxiao; Zhang, Erik; Guo, Yanan; Wu, Chin-Lee; Auricchio, Neil; Priolo, Carmen; Li, Jing; Csibi, Alfredo; Parkhitko, Andrey; Morrison, Tasha; Planaguma, Anna; Kazani, Shamsah; Israel, Elliot; Xu, Kai-Feng; Henske, Elizabeth Petri; Blenis, John; Levy, Bruce D.; Kwiatkowski, David; Yu, Jane J. (The Rockefeller University Press, 2014)
      Lymphangioleiomyomatosis (LAM) is a progressive neoplastic disorder that leads to lung destruction and respiratory failure primarily in women. LAM is typically caused by tuberous sclerosis complex 2 (TSC2) mutations resulting ...
    • Faslodex Inhibits Estradiol-Induced Extracellular Matrix Dynamics and Lung Metastasis in a Model of Lymphangioleiomyomatosis 

      Li, Chenggang; Zhou, Xiaobo; Sun, Yang; Zhang, Erik; Mancini, John D.; Parkhitko, Andrey A.; Morrison, Tasha A.; Silverman, Edwin Kepner; Henske, Elizabeth Petri; Yu, Jane J. (American Thoracic Society, 2013)
      Lymphangioleiomyomatosis (LAM) is a destructive lung disease primarily affecting women. Genetic studies indicate that LAM cells carry inactivating tuberous sclerosis complex (TSC)–2 mutations, and metastasize to the lung. ...
    • Folliculin regulates cell–cell adhesion, AMPK, and mTORC1 in a cell‐type‐specific manner in lung‐derived cells 

      Khabibullin, Damir; Medvetz, Douglas A.; Pinilla, Miguel; Hariharan, Venkatesh; Li, Chenggang; Hergrueter, Anja; Laucho Contreras, Maria; Zhang, Erik; Parkhitko, Andrey; Yu, Jane J.; Owen, Caroline A.; Huang, Hayden; Baron, Rebecca M.; Henske, Elizabeth P. (Wiley Periodicals, Inc., 2014)
      Abstract Germline loss‐of‐function BHD mutations cause cystic lung disease and hereditary pneumothorax, yet little is known about the impact of BHD mutations in the lung. Folliculin (FLCN), the product of the Birt–Hogg–Dube ...
    • Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion 

      Medvetz, Douglas A; Khabibullin, Damir; Hariharan, Venkatesh; Ongusaha, Pat P.; Goncharova, Elena A.; Schlechter, Tanja; Darling, Thomas N.; Hofmann, Ilse; Krymskaya, Vera P.; Liao, James K.; Huang, Hayden; Henske, Elizabeth Petri (Public Library of Science, 2012)
      Birt-Hogg-Dube (BHD) is a tumor suppressor gene syndrome associated with fibrofolliculomas, cystic lung disease, and chromophobe renal cell carcinoma. In seeking to elucidate the pathogenesis of BHD, we discovered a physical ...
    • Loss of the Birt–Hogg–Dube Tumor Suppressor Results in Apoptotic Resistance due to Aberrant TGFb-Mediated Transcription 

      Cash, T P; Gruber, J J; Hartman, T R; Henske, Elizabeth Petri; Simon, M. C. (Nature Publishing Group, 2011)
      Birt–Hogg–Dubé (BHD) syndrome is an inherited cancer susceptibility disease characterized by skin and kidney tumors, as well as cystic lung disease, which results from loss-of-function mutations in the BHD gene. BHD is ...
    • MicroRNA-21 is Induced by Rapamycin in a Model of Tuberous Sclerosis (TSC) and Lymphangioleiomyomatosis (LAM) 

      Trindade, Anil Julius; Medvetz, Douglas A; Neuman, Nicole A.; Myachina, Faina; Yu, Jane J; Priolo, Carmen; Henske, Elizabeth Petri (Public Library of Science, 2013)
      Lymphangioleiomyomatosis (LAM), a multisystem disease of women, is manifest by the proliferation of smooth muscle-like cells in the lung resulting in cystic lung destruction. Women with LAM can also develop renal ...
    • Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis 

      Neuman, Nicole A; Henske, Elizabeth Petri (WILEY-VCH Verlag, 2011)
      The protein products of the tuberous sclerosis complex (TSC) genes, TSC1 and TSC2, form a complex, which inhibits the small G-protein, Ras homolog enriched in brain (Rheb). The vast majority of research regarding these ...
    • Rabin8 Protein Interacts with GTPase Rheb and Inhibits Phosphorylation of Ser235/Ser236 in Small Ribosomal Subunit Protein S6 

      Parkhitko, А.А.; Favorova, О.О.; Henske, Elizabeth Petri (A.I. Gordeyev, 2011)
      The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that in association with Raptor, mLST8, PRAS40 and Deptor forms a complex (mTORC1) playing the key role in the regulation of protein biosynthesis, ...
    • Real-Time Monitoring of Tumorigenesis, Dissemination, & Drug Response in a Preclinical Model of Lymphangioleiomyomatosis/Tuberous Sclerosis Complex 

      Liu, Fangbing; Lunsford, Elaine P.; Tong, Jingli; Ashitate, Yoshitomo; Gibbs, Summer L.; Yu, Jane J; Choi, Hak Soo; Henske, Elizabeth Petri; Frangioni, John Vincent (Public Library of Science, 2012)
      Background: TSC2-deficient cells can proliferate in the lungs, kidneys, and other organs causing devastating progressive multisystem disorders such as lymphangioleiomyomatosis (LAM) and tuberous sclerosis complex (TSC). ...
    • Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex 

      Liang, Ning; Zhang, Chi; Dill, Patricia; Panasyuk, Ganna; Pion, Delphine; Koka, Vonda; Gallazzini, Morgan; Olson, Eric N.; Lam, Hilaire; Henske, Elizabeth P.; Dong, Zheng; Apte, Udayan; Pallet, Nicolas; Johnson, Randy L.; Terzi, Fabiola; Kwiatkowski, David J.; Scoazec, Jean-Yves; Martignoni, Guido; Pende, Mario (The Rockefeller University Press, 2014)
      Genetic studies have shown that the tuberous sclerosis complex (TSC) 1–TSC2–mammalian target of Rapamycin (mTOR) and the Hippo–Yes-associated protein 1 (YAP) pathways are master regulators of organ size, which are often ...
    • Unjamming and cell shape in the asthmatic airway epithelium 

      Park, Jin-Ah; Kim, Jae Hun; Bi, Dapeng; Mitchel, Jennifer; Qazvini, Nader Taheri; Tantisira, Kelan; Park, Chan Young Young; McGill, Maureen P; Kim, Sae-Hoon; Gweon, Bomi; Notbohm, Jacob K; Steward Jr, Robert; Burger, Stephanie; Randell, Scott H.; Kho, Alvin Thong-Juak; Tambe, Dhananjay; Hardin, Corey; Shore, Stephanie Ann; Israel, Elliot; Weitz, David A.; Tschumperlin, Daniel; Henske, Elizabeth Petri; Weiss, Scott Tillman; Manning, Mary Ellen; Butler, James P.; Drazen, Jeffrey Mark; Fredberg, Jeffrey J. (Nature Publishing Group, 2015)
      From coffee beans flowing in a chute to cells remodelling in a living tissue, a wide variety of close-packed collective systems— both inert and living—have the potential to jam. The collective can sometimes flow like a ...
    • Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development 

      Giannikou, Krinio; Malinowska, Izabela A.; Pugh, Trevor J.; Yan, Rachel; Tseng, Yuen-Yi; Oh, Coyin; Kim, Jaegil; Tyburczy, Magdalena E.; Chekaluk, Yvonne; Liu, Yang; Alesi, Nicola; Finlay, Geraldine A.; Wu, Chin-Lee; Signoretti, Sabina; Meyerson, Matthew; Getz, Gad; Boehm, Jesse S.; Henske, Elizabeth P.; Kwiatkowski, David J. (Public Library of Science, 2016)
      Renal angiomyolipoma is a kidney tumor in the perivascular epithelioid (PEComa) family that is common in patients with Tuberous Sclerosis Complex (TSC) and Lymphangioleiomyomatosis (LAM) but occurs rarely sporadically. ...