Now showing items 1-9 of 9

    • Diabetic Peripheral Neuropathy as a Predictor of Asymptomatic Myocardial Ischemia in Type 2 Diabetes Mellitus: A Cross-Sectional Study 

      Baltzis, Dimitrios; Roustit, Matthieu; Grammatikopoulou, Maria G.; Katsaboukas, Dimitrios; Athanasiou, Vassileios; Iakovou, Ioannis; Veves, Aristidis; Manes, Christos; Trakatelli, Maria-Christina (Springer Healthcare, 2016)
      Introduction: Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes and has been associated with cardiovascular disease, the leading cause of mortality in diabetes. As asymptomatic ...
    • Foot Muscle Energy Reserves in Diabetic Patients Without and With Clinical Peripheral Neuropathy 

      Doupis, John; Kuchibhotla, Sarada; Julliard, Walker; Gnardellis, Charalambos; Dinh, Thanh L.; Lyons, Thomas Edward; Rosenblum, Barry Ira; Wang, Xiaoen; Giurini, John Mario; Greenman, Robert L.; Veves, Aristidis (American Diabetes Association, 2009)
      Objective: To investigate changes in the foot muscle energy reserves in diabetic non-neuropathic and neuropathic patients. Research Design and Methods: We measured the phosphocreatinine (PCr)/inorganic phosphate (Pi) ratio, ...
    • Genome-wide DNA methylation analysis identifies a metabolic memory profile in patient-derived diabetic foot ulcer fibroblasts 

      Park, Lara K; Maione, Anna G; Smith, Avi; Gerami-Naini, Behzad; Iyer, Lakshmanan K; Mooney, David J; Veves, Aristidis; Garlick, Jonathan A (Taylor & Francis, 2014)
      Diabetic foot ulcers (DFUs) are a serious complication of diabetes. Previous exposure to hyperglycemic conditions accelerates a decline in cellular function through metabolic memory despite normalization of glycemic control. ...
    • Impaired Distal Thermoregulation in Diabetes and Diabetic Polyneuropathy 

      Rutkove, Seward Brian; Veves, Aristidis; Mitsa, Theophano; Nie, Rui; Fogerson, Patricia M.; Garmirian, Lindsay P.; Nardin, Rachel Austen (American Diabetes Association, 2009)
      Objective: To determine how thermoregulation of the feet is affected by diabetes and diabetic polyneuropathy in both wakefulness and sleep. Research Design and Methods: Normal subjects, diabetic subjects without neuropathy, ...
    • Mechanisms Involved in the Development and Healing of Diabetic Foot Ulceration 

      Dinh, Thanh; Tecilazich, Francesco; Kafanas, Antonios; Doupis, John; Gnardellis, Charalambos; Leal, Ermelindo; Tellechea, Ana; Pradhan, Leena; Lyons, Thomas E.; Giurini, John M.; Veves, Aristidis (American Diabetes Association, 2012)
      We examined the role of vascular function and inflammation in the development and failure to heal diabetic foot ulcers (DFUs). We followed 104 diabetic patients for a period of 18.4 ± 10.8 months. At the beginning of the ...
    • Molecular Biomarkers of Vascular Dysfunction in Obstructive Sleep Apnea 

      Kaczmarek, Elzbieta; Bakker, Jessie P.; Clarke, Douglas N.; Csizmadia, Eva; Kocher, Olivier; Veves, Aristidis; Tecilazich, Francesco; O'Donnell, Christopher P.; Ferran, Christiane; Malhotra, Atul (Public Library of Science, 2013)
      Untreated and long-lasting obstructive sleep apnea (OSA) may lead to important vascular abnormalities, including endothelial cell (EC) dysfunction, hypertension, and atherosclerosis. We observed a correlation between ...
    • O-Glycosylation Regulates Ubiquitination and Degradation of the Anti-Inflammatory Protein A20 to Accelerate Atherosclerosis in Diabetic ApoE-Null Mice 

      Shrikhande, Gautam V.; Scali, Salvatore T.; Csizmadia, Eva; Matthey, Michaela; Arjoon, Roy; Patel, Rakesh; Maccariello, Elizabeth R.; Andersen, Nicholas D.; Monahan, Thomas; Studer, Peter; Padilha Guedes, Renata; Usheva, Anny; Da Silva, Cleide Gonsalves; Damrauer, Scott Michael; Putheti, Prabhakar; Siracuse, Jeffrey Joseph; Peterson, Clayton Ross; Essayagh, Sanah; Kocher, Olivier Nicolas; Veves, Aristidis; Kaczmarek, Elzbieta; Ferran, Christiane (Public Library of Science, 2010)
      Background: Accelerated atherosclerosis is the leading cause of morbidity and mortality in diabetic patients. Hyperglycemia is a recognized independent risk factor for heightened atherogenesis in diabetes mellitus (DM). ...
    • Protocol for a Systematic Review and Individual Patient Data Meta-analysis of Prognostic Factors of Foot Ulceration in People with Diabetes: The International Research Collaboration for the Prediction of Diabetic Foot Ulcerations (PODUS). 

      Crawford, Fay; Anandan, Chantelle; Chappell, Francesca M; Murray, Gordon D; Price, Jacqueline F; Sheikh, Aziz; Simpson, Colin R; Maxwell, Martin; Stansby, Gerard P; Young, Matthew J; Abbott, Caroline A; Boulton, Andrew JM; Boyko, Edward J; Kastenbauer, Thomas; Leese, Graham P; Monami, Matteo; Monteiro-Soares, Matilde; Rith-Najarian, Stephen J; Veves, Aristidis; Coates, Nikki; Jeffcoate, William J; Leech, Nicola; Fahey, Tom; Tierney, Jayne (Springer (Biomed Central Ltd.), 2013)
    • Role of Endothelial Progenitor Cells and Inflammatory Cytokines in Healing of Diabetic Foot Ulcers 

      Tecilazich, Francesco; Dinh, Thanh; Pradhan-Nabzdyk, Leena; Leal, Ermelindo; Tellechea, Ana; Kafanas, Antonios; Gnardellis, Charalambos; Magargee, Mary L.; Dejam, Andre; Toxavidis, Vasilis; Tigges, John C.; Carvalho, Eugenia; Lyons, Thomas E.; Veves, Aristidis (Public Library of Science, 2013)
      Background: To evaluate changes in endothelial progenitor cells (EPCs) and cytokines in patients with diabetic foot ulceration (DFU) in association with wound healing. Methods: We studied healthy subjects, diabetic patients ...