Now showing items 1-14 of 14

    • The association of circulating angiogenic factors and HbA1c with the risk of preeclampsia in women with preexisting diabetes 

      Cohen, Allison L.; Wenger, Julia B.; James-Todd, Tamarra; Lamparello, Brooke M.; Halprin, Elizabeth Susannah; Serdy, Shanti; Fan, Shuling; Horowitz, Gary Leigh; Lim, Kee-Hak; Rana, Sarosh; Takoudes, Tamara C.; Wyckoff, Jennifer A.; Thadhani, Ravi I.; Karumanchi, Subbian Ananth; Brown, Florence Mavis (Informa UK Limited, 2014)
      Objective: To assess whether glycemic control, soluble fms-like tyrosine kinase 1 (sFlt1) and placental growth factor (PlGF) were associated with the development of preeclampsia (PE) or gestational hypertension (GHTN) in ...
    • Bioavailable Vitamin D Is More Tightly Linked to Mineral Metabolism than Total Vitamin D in Incident Hemodialysis Patients 

      Bhan, Ishir; Powe, Camille Elise; Berg, Anders Hayden; Ankers, Elizabeth; Wenger, Julia; Karumanchi, Subbian Ananth; Thadhani, Ravi Ishwar (Nature Publishing Group, 2012)
      Prior studies showed conflicting results regarding the association between 25-hydroxyvitamin D (25(OH)D) levels and mineral metabolism in end-stage renal disease. In order to determine whether the bioavailable vitamin D ...
    • Calciphylaxis in peritoneal dialysis patients: a single center cohort study 

      Zhang, Yanchen; Corapi, Kristin M; Luongo, Maria; Thadhani, Ravi; Nigwekar, Sagar U (Dove Medical Press, 2016)
      Background: Calciphylaxis is a rare but devastating condition in end-stage renal disease (ESRD) patients. Most research in the field of calciphylaxis is focused on hemodialysis (HD) patients; however, data on calciphylaxis ...
    • Circulating Angiogenic Factors and the Risk of Adverse Outcomes among Haitian Women with Preeclampsia 

      March, Melissa I.; Geahchan, Carl; Wenger, Julia; Raghuraman, Nandini; Berg, Anders; Haddow, Hamish; Mckeon, Bri Ann; Narcisse, Rulx; David, Jean Louis; Scott, Jennifer; Thadhani, Ravi; Karumanchi, S. Ananth; Rana, Sarosh (Public Library of Science, 2015)
      Objective: Angiogenic factors are strongly associated with adverse maternal and fetal outcomes among women with preterm preeclampsia (PE) in developed countries. We evaluated the role of angiogenic factors and their ...
    • Copy Number Variation at the APOL1 Locus 

      Ruchi, Rupam; Genovese, Giulio; Lee, Jessica; Charoonratana, Victoria T.; Bernhardy, Andrea J.; Alper, Seth L.; Kopp, Jeffrey B.; Thadhani, Ravi; Friedman, David J.; Pollak, Martin R. (Public Library of Science, 2015)
      Two coding variants in the APOL1 gene (G1 and G2) explain most of the high rate of kidney disease in African Americans. APOL1-associated kidney disease risk inheritance follows an autosomal recessive pattern: The relative ...
    • First-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitus 

      Thadhani, Ravi Ishwar; Powe, Camille Elise; Tjoa, May Lee; Khankin, Eliyahu; Ye, Jun; Ecker, Jeffrey Lawrence; Schneyer, Alan; Karumanchi, Subbian Ananth (American Diabetes Association, 2009)
      Objective: To determine whether maternal levels of follistatin-like-3 (FSTL3), an inhibitor of activin and myostatin involved in glucose homeostasis, are altered in the first trimester of pregnancies complicated by subsequent ...
    • Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice 

      Cavalli, Ricardo C.; Cerdeira, Ana Sofia; Pernicone, Elizabeth; Korkes, Henri A.; Burke, Suzanne D.; Rajakumar, Augustine; Thadhani, Ravi I.; Roberts, Drucilla J.; Bhasin, Manoj; Karumanchi, S. Ananth; Kopcow, Hernan D. (Public Library of Science, 2016)
      Decidual NK (dNK) cells, a distinct type of NK cell, are thought to regulate uterine spiral artery remodeling, a process that allows for increased blood delivery to the fetal-placental unit. Impairment of uterine spiral ...
    • Low-Molecular Weight Heparin Increases Circulating sFlt-1 Levels and Enhances Urinary Elimination 

      Hagmann, Henning; Bossung, Verena; Belaidi, Abdel Ali; Fridman, Alexander; Karumanchi, S. Ananth; Thadhani, Ravi; Schermer, Bernhard; Mallmann, Peter; Schwarz, Guenter; Benzing, Thomas; Brinkkoetter, Paul T. (Public Library of Science, 2014)
      Rationale: Preeclampsia is a devastating medical complication of pregnancy which leads to maternal and fetal morbidity and mortality. While the etiology of preeclampsia is unclear, human and animal studies suggest that ...
    • Modeling risk for severe adverse outcomes using angiogenic factor measurements in women with suspected preterm preeclampsia 

      Palomaki, Glenn E; Haddow, James E; Haddow, Hamish R M; Salahuddin, Saira; Geahchan, Carl; Cerdeira, Ana Sofia; Verlohren, Stefan; Perschel, Frank H; Horowitz, Gary; Thadhani, Ravi; Karumanchi, S Ananth; Rana, Sarosh (Blackwell Publishing Ltd, 2015)
      Introduction: Preeclampsia (PE) is a pregnancy-specific syndrome associated with adverse maternal and fetal outcomes. Patient-specific risks based on angiogenic factors might better categorize those who might have a severe ...
    • Plasma Concentrations of Soluble Endoglin versus Standard Evaluation in Patients with Suspected Preeclampsia 

      Rana, Sarosh; Cerdeira, Ana Sofia Teixeira de; Wenger, Julia; Salahuddin, Saira; Lim, Kee-Hak; Ralston, Steven Joseph; Thadhani, Ravi Ishwar; Karumanchi, Subbian Ananth (Public Library of Science, 2012)
      Background: The purpose of this study was to compare plasma soluble endoglin (sEng) levels with standard clinical evaluation or plasma levels of other angiogenic proteins [soluble fms-like tyrosine kinase 1 (sFlt1) and ...
    • Protein carbamylation is associated with heart failure and mortality in diabetic patients with end stage renal disease 

      Drechsler, Christiane; Kalim, Sahir; Wenger, Julia B.; Suntharalingam, Pirianthini; Hod, Tammy; Thadhani, Ravi I.; Karumanchi, S. Ananth; Wanner, Christoph; Berg, Anders H. (2015)
      Serum carbamylated albumin (C-Alb) levels are associated with excess mortality in patients with diabetic end stage renal disease. To gain insight into the pathophysiology of carbamylation, we determined associations between ...
    • Short and Long-Term Effects of Telaprevir on Kidney Function in Patients with Hepatitis C Virus Infection: A Retrospective Cohort Study 

      Sise, Meghan E.; Backman, Elke S.; Wenger, Julia B.; Wood, Brian R.; Sax, Paul E.; Chung, Raymond T.; Thadhani, Ravi; Kim, Arthur Y. (Public Library of Science, 2015)
      Background: Recent reports suggest that telaprevir, a protease inhibitor used to treat hepatitis C infection, is associated with decline in kidney function during therapy, particularly in patients with baseline renal ...
    • Soluble Erythropoietin Receptor Contributes to Erythropoietin Resistance in End-Stage Renal Disease 

      Khankin, Eliyahu; Mutter, Walter Peter; Tamez, Hector; Yuan, Hai-Tao; Karumanchi, Subbian Ananth; Thadhani, Ravi Ishwar (Public Library of Science, 2010)
      Background: Erythropoietin is a growth factor commonly used to manage anemia in patients with chronic kidney disease. A significant clinical challenge is relative resistance to erythropoietin, which leads to use of ...
    • Trace Elements in Hemodialysis Patients: A Systematic Review and Meta-Analysis 

      Tonelli, Marcello; Wiebe, Natasha; Hemmelgarn, Brenda; Klarenbach, Scott; Field, Catherine; Manns, Braden; Thadhani, Ravi Ishwar; Gill, John (BioMed Central, 2009)
      Background: Hemodialysis patients are at risk for deficiency of essential trace elements and excess of toxic trace elements, both of which can affect health. We conducted a systematic review to summarize existing literature ...