Now showing items 1-3 of 3

    • Deficiency of FcεR1 increases body weight gain but improves glucose tolerance in diet-induced obese mice 

      Lee, Yun-Jung; Liu, Conglin; Liao, Mengyang; Sukhova, Galina K.; Shirakawa, Jun; Abdennour, Meriem; Iamarene, Karine; Andre, Sebastien; Inouye, Karen; Clement, Karine; Kulkarni, Rohit Narayan; Banks, Alexander; Libby, Peter; Shi, Guo-Ping (Endocrine Society, 2015)
      Prior studies demonstrated increased plasma immunoglobulin E (IgE) in diabetic patients, but the direct participation of IgE in diabetes or obesity remains unknown. This study found that plasma IgE levels correlated inversely ...
    • Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter 

      Wang, Jing; Sun, Chongxiu; Gerdes, Norbert; Liu, Conglin; Liao, Mengyang; Liu, Jianping; Shi, Michael A; He, Aina; Zhou, Yi; Sukhova, Galina K.; Chen, Huimei; Cheng, Xian; Kuzuya, Masafumi; Murohara, Toyoaki; Zhang, Jie; Cheng, Xiang; Jiang, Mengmeng; Shull, Gary E; Rogers, Shaunessy; Yang, Chao-Ling; Ke, Qiang; Jelen, Sabina; Bindels, René; Ellison, David H; Jarolim, Petr; Libby, Peter; Shi, Guo-Ping (Nature Publishing Group, 2015)
      Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms1, 2. Interruption of IL18 action reduces atherosclerosis in mice3, 4. Here, we show that absence of the IL18 receptor (IL18r) does not ...
    • Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages 

      Zhou, Yi; Yu, Xueqing; Chen, Huimei; Sjöberg, Sara; Roux, Joséphine; Zhang, Lijun; Ivoulsou, Al-Habib; Bensaid, Farid; Liu, Jian; Tordjman, Joan; Clement, Karine; Lee, Chih-Hao; Libby, Peter; Shi, Guo-Ping; Hotamisligil, Gokhan; Liu, Conglin (Elsevier BV, 2015-12)
      Mast cells (MCs) contribute to the pathogenesis of obesity and diabetes. This study demonstrates that leptin deficiency slants MCs toward anti-inflammatory functions. MCs in the white adipose tissue (WAT) of lean humans ...