Now showing items 1-4 of 4

    • FlyRNAi.org—the database of the Drosophila RNAi screening center and transgenic RNAi project: 2017 update 

      Hu, Yanhui; Comjean, Aram; Roesel, Charles; Vinayagam, Arunachalam; Flockhart, Ian; Zirin, Jonathan; Perkins, Lizabeth; Perrimon, Norbert; Mohr, Stephanie E. (Oxford University Press, 2017)
      The FlyRNAi database of the Drosophila RNAi Screening Center (DRSC) and Transgenic RNAi Project (TRiP) at Harvard Medical School and associated DRSC/TRiP Functional Genomics Resources website (http://fgr.hms.harvard.edu) ...
    • Integrating protein-protein interaction networks with phenotypes reveals signs of interactions 

      Vinayagam, Arunachalam; Zirin, Jonathan; Roesel, Charles; Hu, Yanhui; Yilmazel, Bahar; Samsonova, Anastasia A.; Neumüller, Ralph A.; Mohr, Stephanie E.; Perrimon, Norbert (2013)
      A major objective of systems biology is to organize molecular interactions as networks and to characterize information-flow within networks. We describe a computational framework to integrate protein-protein interaction ...
    • Regulators of Autophagosome Formation in Drosophila Muscles 

      Zirin, Jonathan; Nieuwenhuis, Joppe; Samsonova, Anastasia; Tao, Rong; Perrimon, Norbert (Public Library of Science, 2015)
      Given the diversity of autophagy targets and regulation, it is important to characterize autophagy in various cell types and conditions. We used a primary myocyte cell culture system to assay the role of putative autophagy ...
    • Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy 

      Zirin, Jonathan; Nieuwenhuis, Joppe; Perrimon, Norbert (Public Library of Science, 2013)
      Several myopathies are associated with defects in autophagic and lysosomal degradation of glycogen, but it remains unclear how glycogen is targeted to the lysosome and what significance this process has for muscle cells. ...