Browsing by Author "Jain, Rakesh"

Now showing items 1-20 of 44

    • Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels 

      Chauhan, Vikash P.; Martin, John D.; Liu, Hao; Lacorre, Delphine A.; Jain, Saloni R.; Kozin, Sergey V.; Stylianopoulos, Triantafyllos; Mousa, Ahmed S.; Han, Xiaoxing; Adstamongkonkul, Pichet; Popović, Zoran; Huang, Peigen; Bawendi, Moungi G.; Boucher, Yves; Jain, Rakesh K. (Nature Pub. Group, 2013)
      Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...

    • Anti-Vascular Endothelial Growth Factor Therapies as a Novel Therapeutic Approach to Treating Neurofibromatosis-Related Tumors 

      Wong, H. K.; Lahdenranta, J.; Kamoun, W. S.; Chan, Ariel Hin Man; McClatchey, Andrea I.; Plotkin, Scott Randall; Jain, Rakesh K.; di Tomaso, E. (American Association for Cancer Research (AACR), 2010)
      Patients with bilateral vestibular schwannomas associated with neurofibromatosis type 2 (NF2) experience significant morbidity such as complete hearing loss. We have recently shown that treatment with bevacizumab provided ...

    • AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients 

      Batchelor, Tracy Todd; Sorensen, A; di Tomaso, Emmanuelle; Zhang, Wei-Ting; Duda, Dan Gabriel; Cohen, Kenneth S.; Kozak, Kevin R.; Cahill, Daniel P.; Chen, Poe-Jou; Zhu, Mingwang; Ancukiewicz, Marek; Mrugala, Maciej M.; Plotkin, Scott Randall; Drappatz, Jan; Louis, David N.; Ivy, Percy; Scadden, David Thomas; Benner, Thomas; Loeffler, Jay Steven; Wen, Patrick Yung Chih; Jain, Rakesh K. (Elsevier BV, 2007)
      Using MRI techniques, we show here that normalization of tumor vessels in recurrent glioblastoma patients by daily administration of AZD2171—an oral tyrosine kinase inhibitor of VEGF receptors—has rapid onset, is prolonged ...

    • Blockade of VEGFR2 and Not VEGFR1 Can Limit Diet-Induced Fat Tissue Expansion: Role of Local versus Bone Marrow-Derived Endothelial Cells 

      Tam, Joshua; Duda, Dan Gabriel; Perentes, Jean Y.; Quadri, Rehan S.; Fukumura, Dai; Jain, Rakesh K. (Public Library of Science, 2009)
      Background: We investigated if new vessel formation in fat involves the contribution of local tissue-derived endothelial cells (i.e., angiogenesis) or bone marrow-derived cells (BMDCs, i.e. vasculogenesis) and if antiangiogenic ...

    • Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology 

      Prabhakar, Uma; Maeda, Hiroshi; Jain, Rakesh; Sevick-Muraca, Eva M.; Zamboni, William; Farokhzad, Omid; Barry, Simon T.; Gabizon, Alberto; Grodzinski, Piotr; Blakey, David C. (American Association for Cancer Research (AACR), 2013-02-19)
      Enhanced permeability of the tumor vasculature allows macromolecules to enter the tumor interstitial space, while the suppressed lymphatic filtration allows them to stay there. This phenomenon - EPR has been the basis of ...

    • Compact Biocompatible Quantum Dots via RAFT-Mediated Synthesis of Imidazole-Based Random Copolymer Ligand 

      Liu, Wenhao; Greytak, Andrew B.; Lee, Jungmin; Wong, Cliff R.; Park, Jongnam; Marshall, Lisa F.; Jiang, Wen; Curtin, Peter N.; Ting, Alice Y.; Nocera, Daniel; Fukumura, Dai; Jain, Rakesh K.; Bawendi, Moungi G. (American Chemical Society (ACS), 2010)
      We present a new class of polymeric ligands for quantum dot (QD) water solubilization to yield biocompatible and derivatizable QDs with compact size (~10-12 nm diameter), high quantum yields (>50%), excellent stability ...

    • Correlative intravital imaging of cGMP signals and vasodilation in mice 

      Thunemann, Martin; Schmidt, Kjestine; de Wit, Cor; Han, Xiaoxing; Jain, Rakesh K.; Fukumura, Dai; Feil, Robert (Frontiers Media S.A., 2014)
      Cyclic guanosine monophosphate (cGMP) is an important signaling molecule and drug target in the cardiovascular system. It is well known that stimulation of the vascular nitric oxide (NO)-cGMP pathway results in vasodilation. ...

    • Differential Effects of Sorafenib on Liver Versus Tumor Fibrosis Mediated by Stromal-Derived Factor 1 alpha/C-X-C Receptor Type 4 Axis and Myeloid Differentiation Antigen-Positive Myeloid Cell Infiltration in Mice 

      Chen, Yunching; Huang, Yuhui; Reiberger, Thomas; Duyverman, Annique M.; Huang, Peigen; Samuel, Rekha; Hiddingh, Lotte; Roberge, Sylvie; Koppel, Christina; Lauwers, Gregory Y.; Zhu, Andrew Xiuxuan; Jain, Rakesh K.; Duda, Dan Gabriel (Wiley-Blackwell, 2014)
      Sorafenib—a broad kinase inhibitor—is a standard therapy for advanced hepatocellular carcinoma (HCC) and has been shown to exert antifibrotic effects in liver cirrhosis, a precursor of HCC. However, the effects of sorafenib ...

    • Direct Evidence that Bevacizumab, an Anti-VEGF Antibody, Up-regulates SDF1 , CXCR4, CXCL6, and Neuropilin 1 in Tumors from Patients with Rectal Cancer 

      Xu, Lauren; Duda, Dan Gabriel; di Tomaso, E.; Ancukiewicz, M.; Chung, Daniel Chulyong; Lauwers, Gregory Y.; Samuel, R.; Shellito, Paul Clarke; Czito, B. G.; Lin, P.-C.; Poleski, M.; Bentley, R.; Clark, J. W.; Willett, C. G.; Jain, Rakesh K. (American Association for Cancer Research (AACR), 2009)
      Clinical studies converge on the observation that circulating cytokines are elevated in most cancer patients by anti-vascular endothelial growth factor (VEGF) therapy. However, the source of these molecules and their ...

    • Effects of Sorafenib on Intra-Tumoral Interstitial Fluid Pressure and Circulating Biomarkers in Patients with Refractory Sarcomas (NCI Protocol 6948) 

      Raut, Chandrajit P; Boucher, Yves; Duda, Dan Gabriel; Morgan, Jeffrey Arnold; Quek, Richard; Ancukiewicz, Marek; Lahdenranta, Johanna; Eder, Joseph Paul; Demetri, George Daniel; Jain, Rakesh K. (Public Library of Science, 2012)
      Purpose: Jain Sorafenib is a multi-targeted tyrosine kinase inhibitor with therapeutic efficacy in several malignancies. Sorafenib may exert its anti-neoplastic effect in part by altering vascular permeability and reducing ...

    • Efficacy and Biomarker Study of Bevacizumab for Hearing Loss Resulting From Neurofibromatosis Type 2–Associated Vestibular Schwannomas 

      Blakeley, Jaishri O.; Ye, Xiaobu; Duda, Dan Gabriel; Halpin, Chris F.; Bergner, Amanda L.; Muzikansky, Alona; Merker, Vanessa; Gerstner, Elizabeth Robins; Fayad, Laura M.; Ahlawat, Shivani; Jacobs, Michael A.; Jain, Rakesh K.; Zalewski, Christopher; Dombi, Eva; Widemann, Brigitte C.; Plotkin, Scott Randall (American Society of Clinical Oncology (ASCO), 2016)
      Purpose Neurofibromatosis type 2 (NF2) is a tumor predisposition syndrome characterized by bilateral vestibular schwannomas (VSs) resulting in deafness and brainstem compression. This study evaluated efficacy and ...

    • Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study 

      Willett, C. G.; Duda, Dan Gabriel; di Tomaso, E.; Boucher, Yves; Ancukiewicz, M.; Sahani, Dushyant V.; Lahdenranta, J.; Chung, Daniel Chulyong; Fischman, A. J.; Lauwers, Gregory Y.; Shellito, Paul Clarke; Czito, B. G.; Wong, T. Z.; Paulson, E.; Poleski, M.; Vujaskovic, Z.; Bentley, R.; Chen, H. X.; Clark, J. W.; Jain, Rakesh K. (American Society of Clinical Oncology (ASCO), 2009)
      PURPOSE: To assess the safety and efficacy of neoadjuvant bevacizumab with standard chemoradiotherapy in locally advanced rectal cancer and explore biomarkers for response. PATIENTS AND METHODS: In a phase I/II study, 32 ...

    • Hearing Improvement after Bevacizumab in Patients with Neurofibromatosis Type 2 

      Plotkin, Scott Randall; Stemmer-Rachamimov, Anat; Barker, Frederick George; Halpin, Chris; Padera, Timothy P.; Tyrrell, Alex; Sorensen, A; Jain, Rakesh K.; di Tomaso, Emmanuelle (New England Journal of Medicine (NEJM/MMS), 2009)
      Background Profound hearing loss is a serious complication of neurofibromatosis type 2, a genetic condition associated with bilateral vestibular schwannomas, benign tumors that arise from the eighth cranial nerve. There ...

    • Improved Tumor Oxygenation and Survival in Glioblastoma Patients Who Show Increased Blood Perfusion After Cediranib and Chemoradiation 

      Batchelor, Tracy; Gerstner, Elizabeth; Emblem, Kyrre E.; Duda, Dan; Kalpathy-Cramer, Jayashree; Snuderl, Matija; Ancukiewicz, Marek; Polaskova, Pavlina; Pinho, Marco C.; Jennings, Dominique; Plotkin, Scott; Chi, Andrew S.; Eichler, April; Dietrich, Jorg; Hochberg, Fred H.; Lu-Emerson, Christine; Iafrate, Anthony; Ivy, S. Percy; Rosen, Bruce; Loeffler, Jay; Wen, Patrick; Sorenson, A. Greg; Jain, Rakesh (National Academy of Sciences, 2013-11-19)
      Antiangiogenic therapy has shown clear activity and improved survival benefit for certain tumor types. However, an incomplete understanding of the mechanisms of action of antiangiogenic agents has hindered optimization and ...

    • Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds 

      Hajjarian, Zeinab; Nia, Hadi Tavakoli; Ahn, Shawn; Grodzinsky, Alan J.; Jain, Rakesh K.; Nadkarni, Seemantini K. (Nature Publishing Group, 2016)
      Natural and synthetic hydrogel scaffolds exhibit distinct viscoelastic properties at various length scales and deformation rates. Laser Speckle Rheology (LSR) offers a novel, non-contact optical approach for evaluating the ...

    • Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy 

      Sahani, Dushyant V; Jiang, Tao; Hayano, Koichi; Duda, Dan G; Catalano, Onofrio A; Ancukiewicz, Marek; Jain, Rakesh K; Zhu, Andrew X (BioMed Central, 2013)
      Background: To investigate the hypothesis that MRI derived diffusion-weighted imaging (DWI) and perfusion (MRP) parameters are sensitive image biomarkers for monitoring early antiangiogenic effects and predicting progression ...

    • Magneto-Fluorescent Core-Shell Supernanoparticles 

      Chen, Ou; Riedemann, Lars; Etoc, Fred; Herrmann, Hendrik; Coppey, Mathieu; Barch, Mariya; Farrar, Christian T.; Zhao, Jing; Bruns, Oliver T.; Wei, He; Guo, Peng; Cui, Jian; Jensen, Russ; Chen, Yue; Harris, Daniel K.; Cordero, Jose M.; Wang, Zhongwu; Jasanoff, Alan; Fukumura, Dai; Reimer, Rudolph; Dahan, Maxime; Jain, Rakesh K.; Bawendi, Moungi G. (2014)
      Magneto-fluorescent particles have been recognized as an emerging class of materials that exhibit great potential in advanced applications. However, synthesizing such magneto-fluorescent nanomaterials that simultaneously ...

    • Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold 

      Lemon, Christopher M.; Curtin, Peter N.; Somers, Rebecca C.; Greytak, Andrew B.; Lanning, Ryan M.; Jain, Rakesh K.; Bawendi, Moungi G.; Nocera, Daniel (American Chemical Society (ACS), 2014)
      Acidity, hypoxia and glucose levels characterize the tumor microenvironment rendering pH, pO2 and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be ...

    • A metastasis map of human cancer cell lines 

      Jin, Xin; Demere, Zelalem; Nair, Karthik; Ali, Ahmed; Ferraro, Gino; Natoli, Ted; Deik, Amy; Petronio, Lia; Tang, Andrew A.; Zhu, Cong; Wang, Li; Rosenberg, Danny; Mangena, Vamsi; Roth, Jennifer; Chung, Kwanghun; Jain, Rakesh; Clish, Clary B.; Vander Heiden, Matthew G.; Golub, Todd R. (Springer Science and Business Media LLC, 2020-12-09)
      Most deaths from cancer are explained by metastasis, and yet large-scale metastasis research has been impractical due to the complexity of in vivo models. Here, we introduce an in vivo barcoding strategy capable of determining ...

    • Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages 

      Incio, Joao; Suboj, Priya; Chin, Shan M.; Vardam-Kaur, Trupti; Liu, Hao; Hato, Tai; Babykutty, Suboj; Chen, Ivy; Deshpande, Vikram; Jain, Rakesh K.; Fukumura, Dai (Public Library of Science, 2015)
      Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with a dismal prognosis for most patients. Fibrosis and inflammation are hallmarks of tumor desmoplasia. We have previously demonstrated ...