Browsing by Author "Palmer, Nathan"
Now showing items 1-5 of 5
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The Drug Data to Knowledge Pipeline: Large-Scale Claims Data Classification for Pharmacologic Insight
Homer, Mark L.; Palmer, Nathan P.; Bodenreider, Olivier; Cami, Aurel; Chadwick, Laura; Mandl, Kenneth D. (American Medical Informatics Association, 2016)In biomedical informatics, assigning drug codes to categories is a common step in the analysis pipeline. Unfortunately, incomplete mappings are the norm rather than the exception with coverage values less than 85% not ... -
Early Detection of Poor Adherers to Statins: Applying Individualized Surveillance to Pay for Performance
Zimolzak, Andrew J.; Spettell, Claire M.; Fernandes, Joaquim; Fusaro, Vincent A.; Palmer, Nathan P.; Saria, Suchi; Kohane, Isaac S.; Jonikas, Magdalena A.; Mandl, Kenneth D. (Public Library of Science, 2013)Background: Medication nonadherence costs $300 billion annually in the US. Medicare Advantage plans have a financial incentive to increase medication adherence among members because the Centers for Medicare and Medicaid ... -
Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures
Prilutsky, Daria; Kho, Alvin T.; Palmer, Nathan P.; Bhakar, Asha L.; Smedemark-Margulies, Niklas; Margulies, David M.; Kong, Sek Won; Bear, Mark F.; Kohane, Isaac S. (BioMed Central, 2015)Background: Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotypes ... -
A Gene Expression Profile of Stem Cell Pluripotentiality and Differentiation Is Conserved across Diverse Solid and Hematopoietic Cancers
Palmer, Nathan Patrick; Schmid, Patrick R; Berger, Bonnie; Kohane, Isaac Samuel (BioMed Central, 2012)Background: Understanding the fundamental mechanisms of tumorigenesis remains one of the most pressing problems in modern biology. To this end, stem-like cells with tumor-initiating potential have become a central focus ... -
Integrative analysis of genetic data sets reveals a shared innate immune component in autism spectrum disorder and its co-morbidities
Nazeen, Sumaiya; Palmer, Nathan P.; Berger, Bonnie; Kohane, Isaac S. (BioMed Central, 2016)Background: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder that tends to co-occur with other diseases, including asthma, inflammatory bowel disease, infections, cerebral palsy, dilated cardiomyopathy, ...