Browsing by Author "Vallender, Eric"
Now showing items 1-8 of 8
-
Bringing non-human primate research into the post-genomic era: how monkeys are teaching us about elite controllers of HIV/AIDS
Vallender, Eric J (BioMed Central, 2014)Whole-genome sequencing of Mauritian cynomolgus macaques reveals novel candidate loci for controlling simian immunodeficiency virus replication. See related Research, http://genomebiology.com/2014/15/11/478 -
Expanding Whole Exome Resequencing into Non-Human Primates
Vallender, Eric (BioMed Central, 2011)Background: Complete exome resequencing has the power to greatly expand our understanding of non-human primate genomes. This includes both a better appreciation of the variation that exists in non-human primate model ... -
Functional Evolution of the Trace Amine Associated Receptors in Mammals and the Loss of TAAR1 in Dogs
Vallender, Eric; Xie, Zhihua; Westmoreland, Susan V.; Miller, Gregory Michael (BioMed Central, 2010)Background: The trace amine associated receptor family is a diverse array of GPCRs that arose before the first vertebrates walked on land. Trace amine associated receptor 1 (TAAR1) is a wide spectrum aminergic receptor ... -
Genetic substructure in cynomolgus macaques (Macaca fascicularis) on the island of Mauritius
Ogawa, Lisa M; Vallender, Eric J (BioMed Central, 2014)Background: Nonhuman primates are commonly used in biomedical research as animal models of human disease and behavior. Compared to common rodent models, nonhuman primates are genetically, physiologically, behaviorally and ... -
Large-scale polymorphism discovery in macaque G-protein coupled receptors
Goswami, Dharmendra B; Ogawa, Lisa M; Ward, Joshua M; Miller, Gregory M; Vallender, Eric J (BioMed Central, 2013)Background: G-protein coupled receptors (GPCRs) play an inordinately large role in human health. Variation in the genes that encode these receptors is associated with numerous disorders across the entire spectrum of disease. ... -
Quantitative Molecular Assessment of Chimerism across Tissues in Marmosets and Tamarins
Sweeney, Carolyn G; Curran, Elizabeth H.; Westmoreland, Susan V.; Mansfield, Keith G.; Vallender, Eric (BioMed Central, 2012)Background: Marmosets are playing an increasingly large and important role in biomedical research. They share genetic, anatomical, and physiological similarities with humans and other primate model species, but their smaller ... -
Refinement of Primate Copy Number Variation Hotspots Identifies Candidate Genomic Regions Evolving Under Positive Selection
Babb, Paul L; Iskow, Rebecca C; Mills, Ryan E; Ionita-Laza, Iuliana; Gokcumen, Omer; Zhu, Qihui; Shi, Xinghua; Vallender, Eric; Clark, Andrew G.; Johnson, Welkin Eric; Lee, Charles (BioMed Central, 2011)Background: Copy number variants (CNVs), defined as losses and gains of segments of genomic DNA, are a major source of genomic variation. Results: In this study, we identified over 2,000 human CNVs that overlap with ... -
Uncovering the Mutation-Fixation Correlation in Short Lineages
Vallender, Eric; Lahn, Bruce T (BioMed Central, 2007)Background: We recently reported a highly unexpected positive correlation between the fixation probability of nonsynonymous mutations (estimated by \(\omega\)) and neutral mutation rate (estimated by \(K_s\)) in mammalian ...